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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Rapid and simple method for puritication of nucleic acids 显示文摘 | SOL C J A SALIMANS M M M JANSEN C L WERTHEIN VAN DILLEN P M E VAN DER-NOORDAA J | 1990 | Journal of Clinical Microbiology1990，28，： | 1 |
| 3 | Risk factors for pulmonary Aspergillus terreus infection in patients with positive culture for filamentous fungi显示文摘 | Castón JJ Linares MJ Gallego C Rivero A Font P Solís F | | 0，，： | 1 |
| 4 | Results of pretransplant treatment of hepatorenal syndrome with terlipressin显示文摘 | SolàE Cárdenas A Ginès P | 2013 | Curr Opin Organ Transplant2013，18，3： | 1 |
| 5 | Quantification of true in vivo (application) accuracy in cranial imageguided surgery:influence of mode of patient registration显示文摘 | MASCOTT C R SOL J C BOUSQUET P | 2006 | Neurosurgery2006，59，11： | 1 |
| 6 | Rapid and simple method forpurification of nucleic acids显示文摘 | BOOM R SOL C J A SALIMANS M M M JANSEN C L WERTHEIM-VAN DILLEN P M EtNOORDAA J | 1990 | Journal of Clinical Microbiology1990，28，： | 1 |
| 7 | Chiari Ⅰ malformation:a rare cause of noncommunicating hydrocephalus treated by third ventriculostomy 显示文摘 | Deeq P Le Guerinel C Sol JC | 2001 | J Neurosurg2001，95，5： | 1 |
| 8 | Osteogenic Differ- entiation of Human Bone Marrow Mesenchymat Stem Cells Seeded on Melt Based Chitosan Scaffolds for Bone Tissue Engineering Applications显示文摘 | Costa-Pinto A R Correlo V M Sol P C | 2009 | Biomacromolecules2009，10，： | 1 |
| 9 | Effects of chronicacarbose treatment on adipocyte insulin responsiveness,serum lev-els of leptin and adiponectin and hypothalamic NPY expression inobese diabetic Wistar rats显示文摘 | Pérez C Fernández-AgullóT De Solís AJ | 2008 | Clin Exp Pharmacol Physiol2008，35，3： | 1 |
| 10 | Characterization of the re- constructed 1918 Spanish influenza pandemic virus显示文摘 | Tumpey T M Basler C F Aguilar P V Zeng H Sol rzano A Swayne D E | 2005 | Science2005，310，： | 1 |
| 11 | Assessment of the suitability of chitosan/poly butylene succinate scaffolds seeded with mouse mesenehymal progenitor cells for a cartilage tis- sueengineering approach显示文摘 | Oliveira J T Correlo V M Sol P C | 2008 | Tissue Engineering:Part A2008，14，： | 1 |
| 12 | A heterodimer of EsxA and EsxB is involved in sporulation and is secreted by a type VIl secretion system in Streptomyces coelicolor 显示文摘 | Akpe San Roman S Facey PD Fernandez-Martinez L Rodriguez C Vallin C Del Sol R Dyson P | 2010 | Microbiology2010，156，6： | 1 |
| 13 | Elevated soluble fas blood concentrations in patients dying from spontaneous intracerebral hemorrhage显示文摘BACKGROUND Several studies of spontaneous intracerebral hemorrhage(SICH)patients have shown apoptotic changes in brain samples after hematoma evacuation.However,there have been no data on the association between blood concentrations of soluble fas(sFas)(the main surface death receptor of the extrinsic apoptosis pathway)and the prognosis of spontaneous intracranial hypotension(SIH)patients.AIM To determine whether there is an association between blood sFas concentrations and SICH patient mortality.METHODS We included patients with severe and supratentorial SIH.Severe was defined as having Glasgow Coma Scale<9.We determined serum sFas concentrations at the time of severe SICH diagnosis.RESULTS We found that non-surviving patients(n=36)compared to surviving patients(n=39)had higher ICH score(P=0.001),higher midline shift(P=0.004),higher serum sFas concentrations(P<0.001),and lower rate of early hematoma evacuation(P=0.04).Multiple logistic regression analysis showed an association between serum sFas concentrations and 30-d mortality(odds ratio=1.070;95%confidence interval=1.014-1.129;P=0.01)controlling for ICH score,midline shift,and early hematoma evacuation.CONCLUSION The association of blood sFas concentrations and SICH patient mortality is a novel finding in our study. | Leonardo Lorente María M Martín Antonia Pérez-Cejas Luis Ramos-Gómez Jordi Solé-Violan Juan J Cáceres Alejandro Jiménez Agustín F González-Rivero | 2023 | World Journal of Critical Care Medicine2023，12，2： | 0 |
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