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| 1 | 基于定量宏基因组学评估肝硬化患者肠道菌群的变化与慢加急性肝衰竭及预后的关系显示文摘【据Gastroenterology 2020年9月报道】题:基于定量宏基因组学评估肝硬化患者肠道菌群的变化与慢加急性肝衰竭及预后的关系(作者SoléC等)肝硬化与肠道菌群组成的改变有关。慢加急性肝衰竭(ACLF)是肝硬化最严重的临床阶段,但目前仍缺乏使用定量宏基因组学研究ACLF中肠道菌群改变的信息。 | SOLéC GUILLY S Da SILVA K 邵玥明 温晓玉 | 2020 | 临床肝胆病杂志2020，36，11： | 4 |
| 2 | 文献快报(4):童年期不良经历与成年期生理损害的关系--1958年英国出生队列研究显示文摘适应负荷(allostatic load,AL)是一种衡量躯体受到长期压力时所导致生理损害程度的评价工具,这种损害可能部分是由于生命早期不良经历所致,因此这个指标通常可作为评价慢性应激暴露水平的生物标志物。Barboza Solís C等通过对童年期不良经历(adverse childhood experiences,ACEs)与中年期适应负荷关系的研究来进一步验证远期不良经历可导致生理功能损害的研究假设。该课题组利用1958年英国出生队列,其中女性3 782人,男性3 753人,共随访了7次。在儿童7岁、11岁和16岁时分别调查了童年期不良经历;在队列人群44岁时,采用神经内分泌系统、免疫与炎症系统、代谢系统、呼吸与心血管系统4个系统14个指标作为评价其适应负荷的可操作性指标,同时调查了健康行为、 | BARBOZA SOLíS C KELLY-IRVING M FANTIN R 苏普玉 | 2015 | 中国学校卫生2015，36，3： | 3 |
| 3 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 4 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 2 |
| 5 | Renal and circulatory dysfunction in cirrhosis: Current management and future perspectives显示文摘 | Elsa Solà Pere Ginès | 2010 | Journal of Hepatology2010，，6： | 2 |
| 6 | Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study显示文摘 | Mónica Guevara Carlos Terra André Nazar Elsa Solà Javier Fernández Marco Pavesi Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，4： | 2 |
| 7 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 8 | Differences in cytochromeP450 enzyme activities between fish and crustacea:relation-ship with the bioaccumulation pattern of polychlorobiphen-yls(PCBs)显示文摘 | Koenig S Fernández P SoléM | 2012 | Aquat Toxicol2012，108，： | 1 |
| 9 | miR-34a regulatesmouse neural stem cell differentiation显示文摘 | Aranha MM Santos DM SoláS | 2011 | PLoS One2011，6，21： | 1 |
| 10 | C677T polymorphism of the methylentetrahydrofolate reductase gene in mothers of children affected with neural tube defects显示文摘 | Morales M A Méndez K Solís E | 2015 | Investigacion clinica2015，56，3： | 1 |
| 11 | Effects of chronic acarbose treatment on adipocyte insulin responsiveness, serum levels of leptin and adiponectin and hypothalamic NPY expression in obese diabetic Wistar rats显示文摘 | Perez C Fern a ndez-Agull o T De Sol i s AJ | 2008 | Clin Exp Pharmacol Physiol2008，35，3： | 1 |
| 12 | Ntrathecal xenogeneic chromafin cell grafts reduce nociceptive behavior in a rodent tonic pain model显示文摘 | Sol JC Sallerin B Larrue S | | 0，，02： | 1 |
| 13 | Behavioural changes and the adaptive diversification of pigeons and doves显示文摘 | Oriol L Sol D Carranza S | 2013 | Proc Biol Sci2013，280，1755： | 1 |
| 14 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 15 | Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis显示文摘 | Rodrigues C M Sol S Castro R E | 2002 | J Lipid Res2002，43，6： | 1 |
| 16 | Microbial decolouration of azo dyes:A review显示文摘 | Solís M Solís A Perez H I | 2012 | Process Biochemistry2012，47，： | 1 |
| 17 | Successful Treatment of Severe Gastrointestinal Bleeding Secondary to Crohn Disease with Recombinant Factor VIIa显示文摘 | Eva Girona Joaquín Borrás-Blasco Venancio Conesa-García Andrés Navarro-Ruiz Javier Solís Mariana Fe García-Sepulcre Israel Oliver-García | 2007 | Southern Medical Journal2007，，6： | 1 |
| 18 | Inhibition of the E2F - 1/ p53/Bax pathway by tauroursodeoxychohc acid in amyloid beta - peptide- induced apoptosis of PC12 ceils 显示文摘 | Ramalho RM RibeiroP S Sol S | 2004 | J Neurochem2004，90，3： | 1 |
| 19 | Design of optical wide-band log-periodic nanoantennas using surface integral equation techniques 显示文摘 | SOL TABOADA J M ARA~O G | 2013 | Optics Communications2013，，8： | 1 |
| 20 | Evaluation of hepatocellular carcinoma using SonoVue, a second generation ultrasound contrast agent: correlation with cellular differentiation显示文摘 | Carlos Nicolau Violeta Catalá Ramón Vilana Rosa Gilabert Luis Bianchi Manel Solé Mario Pagés Concepció Brú | 2004 | European Radiology2004，，6： | 1 |
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