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| 1 | Laparoscopic and robot-assisted laparoscopic digestivesurgery:Present and future directions显示文摘Laparoscopic surgery is applied today worldwide to most digestive procedures. In some of them, such as cholecystectomy, Nissen's fundoplication or obesity surgery, laparoscopy has become the standard in practice. In others, such as colon or gastric resection, the laparoscopic approach is frequently used and its usefulness is unquestionable. More complex procedures, such as esophageal, liver or pancreatic resections are, however, more infrequently performed, due to the high grade of skill necessary. As a result, there is less clinical evidence to support its implementation. In the recent years, robot-assisted laparoscopic surgery has been increasingly applied, again with little evidence for comparison with the conventional laparoscopic approach. This review will focus on the complex digestive procedures as well as those whose use in standard practice could be more controversial. Also novel robot-assisted procedures will be updated. | Juan C Rodríguez-Sanjuán Marcos Gómez-Ruiz Soledad Trugeda-Carrera Carlos Manuel-Palazuelos Antonio López-Useros Manuel Gómez-Fleitas | 2016 | World Journal of Gastroenterology2016，22，6： | 27 |
| 2 | Flow - through bulk optode for the spectrophotometric determination of perchlorate 显示文摘 | Soledad G Isabel A | 2003 | Microchim Acta2003，143，1： | 1 |
| 3 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
| 4 | Determination of bisphenols A and F and their diglycidyl ethers in wastewater and river water by coacervative extraction and liquid chromatography fluorimetry 显示文摘 | Ballesteros- G mez Ana Ruiz Francisco- Javier Rubio Soledad | 2007 | Analytica Chimica Acta2007，603，1： | 1 |
| 5 | Oxidativestress and inflammation,a link between chronickidney disease and cardiovascular disease 显示文摘 | Victoria C Marian G Soledad G | 2008 | Kid-ney Int2008，74，12： | 1 |
| 6 | Tyrosinase kinetics:A semiquantitative model of the mechanism of oxidation of monohydric and dihydric phenolic substrate-reply 显示文摘 | Juana C Soledad C Francisco G | 2000 | Journal of Theoretical Biology2000，203，1： | 1 |
| 7 | Frequency of cognitive im-pairment without dementia in patients with stroke a two -year fol - low - up study 显示文摘 | Soledad S Julio D Elena R G | 2007 | J Stroke2007，38，： | 1 |
| 8 | Prediction of total fat, fatty acid composition and nutritional parameters in fish fillets using MID-FTIR spectroscopy and chemometrics显示文摘 | Hem Ondez-Martinez M Gallardo-el6zquez T Osorio-Revilla G Almaraz-Abarca N Ponce-Mendoza A Soledad Vtsquez-Murrieta M | 2013 | LWT-Food Science and Technology2013，52，1： | 1 |
| 9 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 10 | The fluvial architecture of the upper Buntsandstein in the Iberian Basin, central Spain 显示文摘 | SOLEDAD G G | 1993 | Sedimentology1993，40，1： | 1 |
| 11 | Differencial polymerase chain reaction with serial dilutions for quantification of MYCN gene amplification in neuroblastoma显示文摘 | Soledad G Reventos J Sanchez J | 1998 | Anticancer Res1998，18，2： | 1 |
| 12 | Or- ganochlorine pesticides accumulation and degradation products in vegetation samples of a contaminated area in Galicia (NW Spain)显示文摘 | MERCEDES B P MARI'A J G SOLEDAD M L | 2005 | Chemosphere2005，58，： | 1 |
| 13 | Organochlorine pesticides accumulation and degradation products in vegetation samples of a contaminated area in Galicia(NW Spain)显示文摘 | Mercedes B P Man'a J G Soledad M L | 2005 | Chemosphere2005，58，： | 1 |
| 14 | Synthesis of chemicallymodified bioactive peptide:recent advances,challengesand developments for medicinal chemistry显示文摘 | Soledad R G Norbert Sewald | 2009 | FutureMed Chem2009，1，7： | 1 |
| 15 | Time trend in incidence of HIV seroeonversion among homosexual men repeatedly tested in Madrid, 1988 -2000显示文摘 | Jorge DR Jesus C Soledad G | 2001 | AIDS2001，15，10： | 1 |
| 16 | Analyses of spectral-biophysical relationships for a corn canopy显示文摘 | Maria A G Soledad C Joaquin M | 1996 | Remote Sensing of Environment1996，55，1： | 1 |
| 17 | Protein stability induced by ligand binding correlates with changes in protein flexibility显示文摘 | Maria Soledad Celej Guillermo G Montich Gerardo D Fidelio | 2003 | Protein Science2003，12，： | 1 |
| 18 | Frequency of cognitive impairment without dementia in patients with stroke a two-year fol-low-up study显示文摘 | Soledad S Julio D Elena R G | | 0，，： | 1 |
| 19 | Analysis of the β-1, 3- glucanolytie system of the biocontrol agent Trichoderma harziahum显示文摘 | Soledad V G Carlos A L M Alfredo H E | 1998 | Appl Environ Microbiol1998，，8： | 1 |
| 20 | Flow - through bulk optode for the spectro- photometric determination of perchlorate 显示文摘 | Soledad G Isabel A | 2003 | Microchin Acta2003，143，1： | 1 |
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