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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Rotoresection versus transurethral resection of the prostate short-term evaluation of a prospective randomized study显示文摘 | Soliman SA Wadie BS Ibrahimel HE | 2007 | J Urol2007，177，3： | 1 |
| 4 | Can Lactobacillu5 acidophilus improve minimal hepatic encephalopathy? A neuro- metabolite study using magnetic resonance spectroscopy显示文摘 | Ziada DH Soliman HH Yamany SA | 2013 | Ar- ab J Gastroenterol2013，14，3： | 1 |
| 5 | Idiopathic intussusception; The role of laparoscopy显示文摘 | Hay SA Kabesh AA Soliman HA | | 0，，04： | 1 |
| 6 | Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients显示文摘 | Soliman AS Bondy ML El-Badawy SA | 2001 | Br J Cancer2001，85，7： | 1 |
| 7 | Incidence analyses of bladder cancer in the Nile delta region of Egypt 显示文摘 | Fedewa SA Soliman AS Ismail K | 2009 | Cancer Epide- miol2009，33，34： | 1 |
| 8 | Contrasting molecular pathology of colorectal carcinoma in Egyptian and western patients显示文摘 | Soliman AS Bondy ML EI-Badawy SA | 2001 | Br J Cancer2001，85，7： | 1 |
| 9 | Platelet rich plasma enhances the immunohistoehemieal exptpssion of platelet derived growth factor and vascular endothelial growthfaetor in the synovium of the meniscectomized rat models of osteoarthritis 显示文摘 | Almasry SM Soliman HM E1-Tarhouny SA | 2015 | Ann Anat2015，197，： | 1 |
| 10 | Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients显示文摘 | Soliman AS Bondy ML EI-Badawy SA | 2001 | Br J Caneer2001，85，7： | 1 |
| 11 | Accrual reliability,earnings persistence,and stock prices显示文摘 | Richardson SA Sloan RG Soliman MT Tuna I | | 0，，03： | 1 |
| 12 | Contrastinig molecular pathology of eoloreetal carcinoma in Egyptian and western patients显示文摘 | Soliman AS Bondy ML E1-Badawy SA | 2001 | Br J Cancer2001，85，7： | 1 |
| 13 | Rotoresection versus transurethral resection of the prostate short-term evaluation of a prospective randomized study显示文摘 | Soliman SA Wadie BS lbrahimel HE | 2007 | J Urol2007，177，3： | 1 |
| 14 | Accrual Reliability, Earnings Persistence and Stock Prices 显示文摘 | Richardson SA Sloan RG Soliman MT | 2005 | Journal of Accounting and Economics2005，39，3： | 1 |
| 15 | A prospective randomised comparative study of endoscopic band ligation versus injection sclerotherapy of bleeding internal haemorrhoids in patients with liver cirrhosis显示文摘 | Awad AE Soliman HH Saif SA | 2012 | Arab J Gastroenterol2012，13，2： | 1 |
| 16 | A new technique for unconstrained and constrained linear LAV parameter estimation显示文摘 | Christensen GS Rouhi AH Soliman SA | 1989 | Can J Electrical Comput Engng1989，14，1： | 1 |
| 17 | Contrasting molecu- lar pathology of colorectal carcinoma in Egyptian and Western pa tients显示文摘 | Soliman AS Bondy ML EI-Badawy SA | 2001 | Br J Cancer2001，85，7： | 1 |
| 18 | Transurethral resection of the prostate:short-term evaluation of a prospective randomized study显示文摘 | SA Soliman BS Wadie EHE Ibrahim | 2007 | J Urol2007，177，3： | 1 |
| 19 | Rotoresection versus transure- thral resection of the prostate short-term evaluation of a prospective ran- domized study 显示文摘 | Soliman SA Wadie BS Ibrahim HE | 2007 | J Urol2007，177，3： | 1 |
| 20 | Combined trichloroacetic acid peel and topical ascorbic acid versus trichloroacetic acid peel alone in the treatment of melasma:a comparative study显示文摘 | Soliman MM Ramadan SA Bassiouny DA | 2007 | J Cosmet Dermatol2007，6，2： | 1 |
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