|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dual roles of PKM2 in cancer metabolism显示文摘癌症房间有高度取决于 glycolysis 而不是 mitochondrial 的不同新陈代谢氧化 phosphorylation 独自一个的、已知的同样氧气的 glycolysis。Pyruvate kinase (PK ) 催化 glycolysis 的最后的步,作为这新陈代谢的显型的一个潜在的管理者出现了。PK 类型 M2 (PKM2 ) 的表示被增加并且便于喂奶在癌症房间的生产,它决定葡萄糖碳是否被降级到 pyruvate 并且喂奶或是进合成进程的 channeled。PKM2 催化活动的调整也调整为房间增长被要求的 DNA 和类脂化合物的合成。然而, PKM2 与高 anabolism 的活动由协调高精力的要求支持癌症房间增长的机制不完全是静止的理解。这评论总结 PKM2 的生物特征并且在癌症新陈代谢以及潜在的治疗学的应用讨论双角色。在癌症生物学上给它的多种的效果, PKM2 为癌症代表一个吸引人的目标治疗。 | Songfang Wu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，1： | 8 |
| 2 | Chronic electrical stimulation induces functional network changes in cortical neuron cultures显示文摘Recent studies demonstrated that a functional brain network could be regarded as a complex network.With the help of network theory,neuroscientists can identify common organizational principles of the functional brain networks.As a consequence,some non-random organizational features,such as'small world'(most of the nodes are not connected directly but can communicate with few intermediate relay steps)and'rich club'(nodes that are rich in connections tend to form strongly interconnected clubs),have been found in functional brain network.Recently,the'small world'organizational feature of neuronal functional networks in vitro was found to be influenced by external applications.However,little is known about the influence of chronic electrical stimulation on functional networks of dissociated cortical cultures during network development.In the present study,cortical cultures were electrically stimulated at a frequency of 0,0.02,and 0.2 Hz,between 7 and 26 days in vitro(DIV).The spontaneous activity of the cortical cultures was recorded using MEAs.Next,a cross-covariance method and graph theory were applied to investigate organizational feature of functional networks.Our results showed that over 3 weeks of stimulation,the network density significantly increased with maturation in the control and 0.02 Hz stimulation groups,but not in 0.2 Hz stimulation groups.Moreover,all the cultures had a small-world topology at 14,18,22,and 26 DIV,free from the effect of chronic electrical stimulation.Besides,we found an asymmetry effect that partial electrical stimulation inhibited the formation of node connections in stimulated areas.This effect was more pronounced at 0.2 Hz than at 0.02 Hz stimulation.Our results suggest that electrical stimulation does not affect the small-world properties of neural cultures.Instead,electrical stimulation modulates connectivity patterns,and neurons within the stimulated area are less connected than neurons outside the stimulated area. | WU SongFang WANG LuBin ZHAO YuWei SUN HongJi LANG YiRan WANG ChangYong HAN JiuQi WANG Yan HAN Yao | 2020 | Science China(Technological Sciences)2020，63，4： | 2 |
| 3 | Evaluation of Intra-myocardial Coronary Blood Flow Waveform During Intra-aortic Balloon Pumping in the Absence or Presence of Coronary Stenosis显示文摘 | Toyota E Songfang L Kimura A | 1996 | Artif Organs1996，20，： | 1 |
| 4 | BioGinspiredsynthesisofZnO polyhedralsinglecrystalsundereggGshellmembranedirection显示文摘 | Su Huilan SongFang DongQun etal | 2011 | AppliedPhysicsA2011，104，1： | 1 |
| 5 | PA6 and Kevlar fiber reinforced isotactic polypropylene: Structure, mechanical properties and crystallization and melting behavior显示文摘 | Zhao Songfang Cheng Lei Guo Yong | 2012 | Materials & Design2012，35，3： | 1 |
| 6 | PsycholO gical nursing on patients with hypertension in primary mental health status, Curative effect and quality of life, reducing显示文摘 | Zhou Jianjun Chert Songfang | 2014 | China modem doctors2014，52，12： | 1 |
| 7 | The comprehensive nursing intervention on patients with essential hypertension treatment compliance, Effects of lifestyle and blood pressure control of显示文摘 | Ye Xiangyang Chen Songfang | 2014 | China modem doctors2014，52，01： | 1 |
| 8 | PA6 and Kevlar fiber reinforced isotactic polypropylene:Structure, mechanical properties and crystallization and melting behavior显示文摘 | Zhao Songfang Cheng Lei Guo Yong | 2012 | Materials and Design2012，35，： | 1 |
| 9 | Effect of Zhutan Tongluo Tang on fibrinolytic activity following intracerebral hemorrhage in rats显示文摘The neuroprotective effect of Zhutan Tongluo Tang is associated with the activities of the fibrinolytic system. Thus the present study was designed to investigate therapeutic effects of Zhutan Tongluo Tang on intracerebral hemorrhage in rats, induced by injecting collagenase into one side of the caudate nucleus. Fibrinolytic indices including tissue plasminogen activator, plasminogen activator inhibitor-1 and D-Dimer were determined. The results obtained demonstrated that Zhutan Tongluo Tang treatment could alleviate the neural and behavioral impairments of intracerebral hemorrhaging rats. Increased frequencies of placing their forelimb correctly and decreased frequencies of turning left were observed. Enzyme linked immunosorbent assay showed that Zhutan Tongluo Tang could significantly elevate the concentration of plasma tissue plasminogen activator and D-Dimer, while depress plasminogen activator inhibitor-1. Immunohistochemistry demonstrated increased levels of catalase and glutathione in whole brain rat tissue following intracerebral hemorrhage. In addition, elevated expression of Bcl-2 in various hippocampal regions was seen. These findings describe the ability of Zhutan Tongluo Tang to activate the fibrinolytic system, and suggests that antioxidant and apoptosis inhibitory mechanisms may be playing a crucial role in protecting against collagenase-induced intracerebral hemorrhage. | Yongxi Jin Xu Li Gaowen Li Lei Guo Fang Li Guoying Liu Songfang Chen Shijue Liu | 2011 | Neural Regeneration Research2011，6，21： | 1 |
| 10 | Effect of intraaortic balloon pumping on septal arterial blood flow velocity waveform during severe left main coronary artery stenos显示文摘 | Kimura A Toyota E Songfang L | 1996 | J Am Cardio1996，27，： | 1 |
| 11 | RESEARCH ON A REAL-TIME CONTROL SYSTEM OF LOW POWER DISSIPATION FOR CONTINUOUS CYCLIC PERITONEAL DIALYSIS(CCPD) CYCLER显示文摘A low power dissipation control system for continuous cyclic peritoneal dialysis (CCPD) cycler and its characteristics are reported. Combined withhemodialysis and renal transplantation, peritoneal dialysis is used mainly for thetreatment of renal failure. CCPD has been developed during 1980's. It provided automatic dialysis procedures during the night to avoid interruptions in patients'dailyroutine. Furthermore,there is a remarkable decrease in peritonitis occurance usingCCPD. The control system is a critical part for CCPD cycler. The system is approvedto be reliable and flexible in practical experiments. When AC power failure,the system can still ensure the completion of dialysis. | Peng Yi Lu Songfang Kong Hua Yang Zibin(Institute of Basic Medical Seiences,Chinese Academy of Medical SciencesSchool of Basic Medicine,Peking Union Medical College,Beijing 100005,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，1： | 0 |
| 12 | THE HEMODYNAMIC EFFECTS OF THE DOUBLE CHAMBER INTRA-AORTIC BALLOON PUMPING显示文摘Our experimental results showed that the effect of the double chamber intra-aortic balloon pumping was better than that of single chamber intraaortic balloon pumping. It significantly improved the hemodynamic parameters andimproved the efficiency of the counterpulsation. The result is consistent with the design of the computer simulation. | Songfang Lu Yi Peng Yusheng Bao Chunren Wang Xiaojun Yu Hua Kong Zibin Yang(Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，2： | 0 |
| 13 | Effects on the renal artery blood flow during the intra-aortic balloonpumping was used显示文摘The effects of intra-aortic balloon pumping(IABP) on hemodynamic parameters inthe kidney were studied. The pulse produced by pumping activated the renal nervoussystem and reduced the renal vascular resistance. Therefore, the reduction of the renalvascular resistance is an important reason for the increase the renal blood flow duringintra-aortic balloon pumping. | Songfang Lu Yusheng Bao Yi Peng Chunren Wang Zibin Yang(Institute of Basic Medical Sciences, PUMC & CAMS, Beijing 100005, China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，3： | 0 |
| 14 | A NEWLY DUPLICATOR FOR PULSATILE AND STEADY FLOW TESTING OF ARTIFICIAL HEART VALVE显示文摘ANEWLYDUPLICATORFORPULSATILEANDSTEADYFLOWTESTINGOFARTIFICIALHEARTVALVEANEWLYDUPLICATORFORPULSATILEANDSTEADYFLOWTESTINGOFARTIF... | Lu Songfang Yang Zibin Peng Yi Dai Weihan Yu Xiaojun Zhu Anping(Institute of Basic Medical Sciences, CAMS,Beijing, 100005,China)Wang Jihai Zhu Xiaodong Li Xiaodong Di Yunxi(Fu Wai Hospital, CAMS,Beijing, 100037,China) | 1996 | Chinese Journal of Biomedical Engineering(English Edition)1996，5，2： | 0 |
| 15 | THE INFLUENCE OF MACROMOLECULES ON FIBRINOGEN COAGULANILITY显示文摘THEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYTHEINFLUENCEOFMACROMOLECULESONFIBRINOGENCOAGULANILITYWangChunren;YangZib... | Wang Chunren Yang Zibin Lu Songfang Xi Tingfei (Institute of Basic Medicine,PUMC,CAMS & Beijing 100005 China) (National institute for the Control of Pharmaceutical andBiological Products,Beijing 100050 China)Ma Weiyuan ( Department of Medical Physi | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
| 16 | Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways显示文摘The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failure. Recently, three of new beta-coronaviruses have emerged to cause serious and widespread illness and death, such as the Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV), Middle East Respiratory Syndrome Coronaviruses (MERS-CoV), and 2019-nCoV (the causative pathogen of Coronavirus Disease 2019 (COVID-19). The COVID-19 is continuing to spread globally. However, the detailed molecular mechanisms have not yet been fully clarified. Since the similarity of the pathological features among 2019-nCoV, SARS-CoV and MERS-CoV, we could speculate the biological features of current COVID-19 by researching those of MERS-CoV and SARS-CoV. Therefore, we analyzed expression levels of miRNA and mRNA profiles of MERS-CoV, SARS-CoV and 2019-nCoV from five public GEO datasets (Table S1). As a result, we found 16 miRNAs potentially target a group of hub genes clustering together to tune the immune response. Notably, viral RNAs have the ability to sponge miR-500a-5p and miR-501-5p, indicating viral RNAs sequestering these two miRNAs to trigger genes expression and contribute to pathogenesis. We hope this study will pave the way to better understand 2019-nCoV pathogenesis and develop the innovative therapeutics. | Qi Guo Linghui Tan Jiajia Pan Songfang Wu Jiansong Huang Fang Yu Jinghan Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员