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	题名	作者	年代	出处	被引量
1	Misdiagnosis of tuberculosis and the clinical relevance of nontuberculous mycobacteria in Zambia显示文摘Objective:To determine the accuracy of TB diagnosis of TB in Zambia in the era of increasing HIV prevalence.Methods:Sputum of the clinically diagnosed TB cases was additionally subjected to liquid culture and molecular identification.This study distinguished between TB cases confirmed by positive Mycobacterium tuberculosis(M.tuberculosis) cultures and mycobacterial disease caused by non-tuberculous mycobacteria(NTM).Results:Only 49% of the 173 presumptively diagnosed TB cases was M.tuberculosis cultured,while in 13% (22) cases,a combination of M.tuberculosis and NTM was found.In 18% of the patients only NTM were cultured.In 28% ,no mycobacteria was cultivable.HIV positive status was correlated with the isolation of NTM(P<0.05).Conclusions:The diagnosis of tuberculosis based on symptoms, sputum smear and/or chest X-ray leads to significant numbers of false-positive TB cases in Zambia,most likely due to the increased prevalence of HIV.The role of NTM in tuberculosislike disease also seems relevant to the false diagnosis of TB in Zambia.	Patricia CAM Buijtels Michael D Iseman Shelagh Parkinson Cas S de Graaff Henri A Verbrugh Pieter LC Petit Dick van Soolingen	2010	Asian Pacific Journal of Tropical Medicine2010，3，5：	2
2	Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid,other drug resistance,and suc-cessful transmission of Mycobacterium tuberculosis in the Nether-lands显示文摘	van Soolingen D de Haas PEW van Doom HR	2000	J Infect Dis2000，182，6：	1
3	Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia显示文摘	Van Soolingen D Oian L De Haas P	1995	J Clin Microbiol1995，33，12：	1
4	Insertion element IS987 from Mycobacterium boris BCG is located in a hot-spot in- tegration region for insertion elements in Mycobacterium tuber-culosis complex strains显示文摘	Hermans P Van Soolingen D Bik E	1991	Infect immun1991，59，8：	1
5	Correlation of virulence,lung pathology,bacterial load and delayed type hypersensitivity responses after infection with different Mycobacterium tuberculosis genotypes in a BALB/c mouse model显示文摘	Dormans J Burger M Aguilar D Hernandez-Pando R Kremer K Roholl P Arend SM van Soolingen D	2004	Clin Exp Immunol2004，137，3：	1
6	Nature of DNA polymorphism in the direct repeat cluster of Mycobacte- rium tuberculosis; application for strain differentiation by a novel typing method显示文摘	Groenen P Bunsehoten A E Soolingen D	2006	Mol Microbiol2006，10，5：	1
7	Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis显示文摘	van Soolingen D Hermans PW de Haas PE	1991	J Clin Microbiol1991，29，11：	1
8	Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains显示文摘	Parwati I van Crevel R van Soolingen D	2010	Lancet Infect Dis2010，10，2：	1
9	Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements显示文摘	Van Soolingen D	2008	J Internal Med2008，249，1：	1
10	Comparison of various repetive DNA element as genetic markers for strain differentiation and epidemiology of Mycobacterium tuberculosis显示文摘	van Soolingen D de Haas PE Hermans PW	1993	J Clin Microbiol1993，33，8：	1
11	Nature of DNA polymorphism in the direct repeat cluster of Mycobacterium tuberculosis: application for strain differentiation by a novel method显示文摘	Groenen P M L Bunchoten A E Soolingen D	1993	Mol Microbiol1993，105，：	1
12	Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains显示文摘	Kremer K van der Werf MJ Au BK Anh DD Kam KM van Doorn HR Borgdorff MW van Soolingen D	2009	Emerg Infect Dis2009，15，2：	1
13	Predominance of a single genotype of Mycobacterium tuberculosis in countries of East Asia显示文摘	van Soolingen D Qian L de Haas PEW	1995	J Clin Microbiol1995，33，：	1
14	A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes显示文摘	López B Aguilar D Orozco H Burger M Espitia C Ritacco V Barrera L Kremer K Hernandez-Pando R Huygen K van Soolingen D	2003	Clin Exp Immunol2003，133，1：	1
15	Differential pattern of cytokine expression by macrophages infected in vitro with different Mycobacterium tuberculosis genotypes显示文摘	Chacón-Salinas R Serafin-López J Ramos-Payán R Méndez-Aragón P Hernández-Pando R Van Soolingen D Flores-Romo L Estrada-Parra S Estrada-Garcia I	2005	Clin Exp Immunol2005，140，3：	1
16	Predominance of a single genotype of Mycobacterium tuberculosis in countries of East Asia显示文摘	van Soolingen D Qian L de Haas PE	1995	J Clin Microbiol1995，33，12：	1
17	Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosis 显示文摘	Tsolaki AG Gagneux S Pym AS Goguet de la Salmoniere YO Kreiswirth BN Van Soolingen D Small PM	2005	J Clin Microbiol2005，43，7：	1
18	Mycobacterium tuberculosis Beijing genotype strains associated with febrile response to treatment显示文摘	van Crevel R Nelwan RH de Lenne W Veeraragu Y van der Zanden AG Amin Z van der Meer JW van Soolingen D	2001	Emerg Infect Dis2001，7，5：	1
19	Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia显示文摘	van Soolingen D Qian L de Haas PE	1995	J Clin Microbiol1995，33，12：	1
20	Analysis of tuberculosis transmission between nationalities in the Netherlands in the period 1993 - 1995 using DNA fingerprinting 显示文摘	Borgdorff MW Nagelkerke N van Soolingen D	1998	Am J Epidemiol1998，147，2：	1

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