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| 1 | Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice显示文摘 | Dong Zhang Alberto Sanchez-Fueyo Kensaku Kawamoto Sophoclis P. Alexopoulos Wensheng Zhang Xin Xiao Zheng | 2010 | Cytokine2010，，3： | 1 |
| 2 | The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: Early failure adversely affects outcome显示文摘 | Sophoclis P.Alexopoulos MelanieMerrill CindyKin LeaMatsuoka FredDorey WaldoConcepcion CarlosEsquivel AndrewBonham | 2012 | Pediatric Transplantation2012，，4： | 1 |
| 3 | Role of liver transplantation in the management of colorectal liver metastases:Challenges and opportunities显示文摘The liver is the most common site of colorectal cancer metastasis.Complete resection of the metastatic tumor is currently the only treatment modality available with a potential for cure.However,only 20%of colorectal liver metastases(CRLM)are considered resectable at the time of presentation.Liver transplantation(LT)has been proposed as an alternative oncologic treatment for patients with unresectable CRLM.This review summarizes the published experiences of LT in the setting of unresectable CRLM from the previous decades and discusses the challenges and future horizons in the field.Contemporary experiences that come mostly from countries with broader access to liver grafts are also explored and their promising findings in terms of overall survival(OS)and disease-free survival(DFS)are outlined along with their study design and methods.The rationale of establishing specific patient selection criteria and the dilemmas around immunosuppressive regimens in patients undergoing LT for CRLM are also highlighted.Additionally,this review describes the findings of studies comparing LT vs chemotherapy alone and LT vs portal vein embolization plus resection for CRLM in terms of OS and DFS.Last but not least,we present current perspectives and ongoing prospective trials that try to elucidate the role of LT for CRLM. | Panagiotis T Tasoudis Ioannis A Ziogas Sophoclis P Alexopoulos John J Fung Georgios Tsoulfas | 2021 | World Journal of Clinical Oncology2021，12，12： | 0 |
| 4 | Management of biliary atresia:To transplant or not to transplant显示文摘Kasai procedure(KP)and liver transplantation(LT)represent the only therapeutic options for patients with biliary atresia(BA),the most common indication for LT in the pediatric population.However,KP represents by no means a radical option but rather a bridging one,as nearly all patients will finally require a liver graft.More and more experts in the field of transplant surgery propose that maybe it is time for a paradigm change in BA treatment and abandon KP as transplantation seems inevitable.Inadequacy of organs yet makes this option currently not feasible,so it seems useful to find ways to maximize the efficacy of KP.In previous decades,multiple studies tried to identify these factors which opt for better results,but in general,outcomes of KP have not improved to the level that was anticipated.This review provides the framework of conditions which favor native liver survival after KP and the ones which optimize a positive LT outcome.Strategies of transition of care at the right time are also presented,as transplantation plays a key role in the surgical treatment of BA.Future studies and further organization in the transplant field will allow for greater organ availability and better outcomes to be achieved for BA patients. | Christos Dimitrios Kakos Ioannis A Ziogas Sophoclis P Alexopoulos Georgios Tsoulfas | 2021 | World Journal of Transplantation2021，11，9： | 0 |
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