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| 1 | Effective treatment of depression improves post-myocardial infarction survival显示文摘AIM: To examine the contribution of treatment resistant depression(TRD) to mortality in depressed postmyocardial infarction(MI) patients independent of biological and social predictors.METHODS: This secondary analysis study utilizes the Enhancing Recovery in Coronary Heart Disease(ENRICHD) clinical trial data.From 1834 depressed patients in the ENRICHD study,there were 770 depressed post-MI patients who were treated for depression.In this study,TRD is defined as having a less than 50% reduction in Hamilton Depression(HAM-D) score from baseline and a HAM-D score of greater than 10 in 6 mo after depression treatment began.Cox regression analysis was used to examine the independent contributions of TRD to mortality after controlling for the biological and social predictors.RESULTS: TRD occurred in 13.4%(n = 103) of the 770 patients treated for depression.Patients with TRD were significantly younger in age(P = 0.04)(mean = 57.0 years,SD = 11.7) than those without TRD(mean = 59.2 years,SD = 12.0).There was a significantly higher percentage of females with TRD(57.3%) compared to females without TRD(47.4%) [χ2(1) = 4.65,P = 0.031].There were significantly more current smokers with TRD(44.7%) than without TRD(33.0%) [χ2(1) = 7.34,P = 0.007].There were no significant differences in diabetes(P = 0.120),history of heart failure(P = 0.258),prior MI(P = 0.524),and prior stroke(P = 0.180) between patients with TRD and those without TRD.Mortality was 13%(n = 13) in patients with TRD and 7%(n = 49) in patients without TRD,with a mean follow-up of 29 mo(18 mo minimum and maximum of 4.5 years).TRD was a significant independent predictor of mortality(HR =1.995; 95%CI: 1.011-3.938,P = 0.046) after controlling for age(HR = 1.036; 95%CI: 1.011-1.061,P = 0.004),diabetes(HR = 2.912; 95%CI: 1.638-5.180,P < 0.001),heart failure(HR = 2.736; 95%CI: 1.551-4.827,P = 0.001),and smoking(HR = 0.502; 95%CI: 0.228-1.105,P = 0.087).CONCLUSION: The analysis of TRD in the ENRICHD study shows that the effective treatment of depression reduced mortality in depressed post-MI patients.It is important to monitor the effectiveness of depression treatment and change treatments if necessary to reduce depression and improve cardiac outcomes in depressed post-MI patients. | Soudabeh Khojasteh Banankhah Erika Friedmann Sue Thomas | 2015 | World Journal of Cardiology2015，7，4： | 8 |
| 2 | Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of microribonucleic acids显示文摘5-flurouracil(5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer(CRC).Despite significant progress in the treatment of CRC during the last decades,5-FU drug resistance remains the most important cause of failure in CRC therapy.Resistance to 5-FU is a complex and multistep process.Different mechanisms including microsatellite instability,increased expression level of key enzyme thymidylate synthase and its polymorphism,increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells.Recently,microribonucleic acids(miRNA)and their alterations were found to have a crucial role in 5-FU resistance.In this regard,the miRNA-mediated mechanisms of 5-FU drug resistance reside among the new fields of pharmacogenetics of CRC drug response that has not been completely discovered.Identification of the biological markers that are related to response to 5-FU-based chemotherapy is an emerging field of precision medicine.This approach will have an important role in defining those patients who are most likely to benefit from 5-FU-based chemotherapy in the future.Thereby,the identification of 5-FU drug resistance mechanisms is an essential step to predict and eventually overcome resistance.In the present comprehensive review,we will summarize the latest knowledge regarding the molecular determinants of response to 5-FU-based chemotherapy in CRC by emphasizing the role of miRNAs. | Amirsaeed Sabeti Aghabozorgi Mostafa Moradi Sarabi Reza Jafarzadeh-Esfehani Shabnaz Koochakkhani Marziyeh Hassanzadeh Soudabeh Kavousipour Ebrahim Eftekhar | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 3 |
| 3 | Comparing seminal plas- ma biomarkers between normospermic and azoospcrmic men 显示文摘 | Soudabeh S Ardekani AM Hodjat M | 2010 | J Reprod lnfertil2010，11，1： | 1 |
| 4 | Case Study of the use of API581 on HK and HP Material Furnace Tubes显示文摘 | Soudabeh A Noori John W H Price | 2005 | Journal of Pressure Vessel Techonlogy2005，127，1： | 1 |
| 5 | Comparing Seminal Plasma Biomarkers between Normospermic and Azoospermic Men 显示文摘 | Soudabeh S Ali M A Mahshid H | 2010 | J Reprod Infertil2010，11，1： | 1 |
| 6 | A Survey on the Effect of Oral Gabapentin on Hemodynamic Changes During Direct Laryngoscopy and Tracheal Intubation and Intraoperative Bleeding in Patients Undergoing Septorhino- plasty显示文摘 | Farzi Farnoush Haddadi Soudabeh Ebrahimpour Neda | 2015 | Anesth Pain Med2015，5，29： | 1 |
| 7 | Comparing seminal plasma biomarkers between normospermie and azoospermie men显示文摘 | Soudabeh S Ardekani AM Hodjat M | 2010 | J Reprod Infertil2010，11，1： | 1 |
| 8 | A risk approach tothe management of boiler tube thinning 显示文摘 | SOUDABEH A N TOHN W H P | 2006 | Nuclear Engineering and Design2006，236，4： | 1 |
| 9 | A risk approach to the management of boiler tube thing显示文摘 | Soudabeh A N Tohn W H P | 2006 | Nuclear Engineering and Design2006，236，4： | 1 |
| 10 | Expression enhancement in trastuzumab therapeutic monoclonal antibody production using genomic amplification with methotrexate显示文摘 | Soudabeh A S Yakhchali B Minuchehr Z | | 0，，2： | 1 |
| 11 | Comparing seminal plasma biomarkers between normospermic and azoospermic men显示文摘 | Soudabeh S Ardekani A M Hodjat M | 2010 | J Reprod Infertil2010，11，1： | 1 |
| 12 | Preparation of promoted nickel catalysts supported on mesoporous nanocrystalline gamma alumina for carbon dioxide methanation reaction显示文摘 | Soudabeh Rahmani Mehran Rezaei Fereshteh Meshkani | 2014 | Journal of Industrial and Engineering Chemistry2014，，： | 1 |
| 13 | Case study of the use of API581 on HK and HP material furnace tubes显示文摘 | Soudabeh John W H Price | 2005 | Journal of pressure vessel techonlogy2005，127，： | 1 |
| 14 | Comparing seminal plas- ma biomarkers between normospermic and azooslermic men 显示文摘 | Soudabeh S Ardekani AM Hodjat M | 2010 | J Reprod Infertil2010，11，1： | 1 |
| 15 | Synthesis of Spiro Heterobicyclic Rings Using Cellulose Sulfuric Acid Under Solvent-Free Conditions显示文摘 | Naser M Khalil P Masoud B Soudabeh K | 2013 | Asian J Chem2013，25，6： | 1 |
| 16 | A risk approach to themanagement of boiler tube thinning显示文摘 | SOUDABEH A N JOHN WHP | 2006 | NuclearEngineering and Design2006，236，： | 1 |
| 17 | Pedestrian street and its effect on economic sustainability of a historical Middle Eastern city:The case of Chaharbagh Abbasi in Isfahan,Iran显示文摘Pedestrianization is an urban revitalization strategy to enhance sustainability and livability in car-oriented cities.Despite many studies in this research field,the effects of pedestrianization on the economy of cities in developing countries still need further investigation.Additionally,the impact of this strategy on the tenant mix of com-mercial and historical areas in Middle East countries is nebulous.To address these inadequacies,we considered Chaharbagh Abbasi street,located in the heart of Isfahan,Iran,and investigated the impact of a pedestrianization project with particular emphasis on how it affects the economic sustainability of existent commercial fabric.Pre-and post-project data along with field observations and quantifications used to assess structural replacements in trade,were analyzed with SPSS and ArcGIS software.The results revealed unexpected outcomes,such as the closure of some traditional businesses(27.5%),a stagnation in sales(69%)and a decrease in job offers(84%)leading the local economy to a fragile situation.Conversely,it was found that the footfall volume increased by 64% and 73% from the retailers’and pedestrians’viewpoints.This evolution along with a wide opening of food and beverage stores(approximately 60%)makes the post-pedestrianization results more promising than earlier predictions.In conclusion,these findings reinforce the importance of pedestrian streets in revitalizing economic activities in historical and commercial areas from the perspective of economic sustainability.Due to the lack of similar investigations in Middle East countries,these findings can support decision-makers and urban planners to take preventive measures in preserving the diversity of individual small shops for upcoming urban rehabilitation projects in terms of pedestrianization. | Soudabeh Shahmoradi Sayyed Mahdi Abtahi Pedro Guimaraes | 2023 | Geography and Sustainability2023，4，3： | 0 |
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