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| 1 | The Cataract National Dataset electronic multi - centre audit of 55, 567 operations: risk izdieators for monocular visual acuity outcomes 显示文摘 | Sparrow JM Taylor H Qureshi K | 2012 | Eye2012，26，6： | 1 |
| 2 | Reeovery ofleukotriene E4 from the urine of patients with air wayobstruetion 显示文摘 | Drazen JM Brien J Sparrow D | 1992 | Am Rev RespirD is1992，146，1： | 1 |
| 3 | The prevalence and analy- sis of risk factors for age-related maeular degeneration: 18-year fol- low-up data from the Speedwell eye study, United Kingdom 显示文摘 | Ngai LY Stocks N Sparrow JM | 2011 | Eye (Lond)2011，25，6： | 1 |
| 4 | Monte-Carlo simulation of random clustering of en- dophthalmitis following cataract surgery显示文摘 | Sparrow JM | 2007 | Eye2007，21，2： | 1 |
| 5 | The national diabetic retinopathy laser treatment audit显示文摘 | Bailey CC Sparrow JM Grey RH | 1999 | Clinical Utcomes Eye1999，13，： | 1 |
| 6 | Formula choice: Hoffer Q, Holladay 1, or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry显示文摘 | Aristodemou P Knox Cartwright NE Sparrow JM | 2011 | Cataract Refract Surg2011，37，1： | 1 |
| 7 | Use of vision tests in clinical decision making about cataract surgery: results of a national survey显示文摘 | Frost NA Sparrow JM | 2000 | Can J Ophthalmol2000，874，4： | 1 |
| 8 | Formula choice:Hoffer Q,Holladay 1,or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry显示文摘 | Aristodemou P Knox Cartwright NE Sparrow JM | | 0，，： | 1 |
| 9 | First eye prediction error improves second eye refractive outcome results in 2 129 patients after bilateral sequential cataract surgery 显示文摘 | Aristodemou P Knox Cartwright NE Sparrow JM | 2011 | Ophthalmology2011，118，： | 1 |
| 10 | Formula choice:Hoffer Q,Holladay 1,or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry显示文摘 | Aristodemou P Knox Cartwright NE Sparrow JM | | 0，，： | 1 |
| 11 | Recovery of leukotriene E4 from the urine of patients with airway obstruction显示文摘 | Drazen JM O'Brien J Sparrow D | 1992 | Am rev respir Dis1992，146，1： | 1 |
| 12 | Amblyopia treatment outcomes after pre- school screening v school entry screening observational data from a prospective cohort study 显示文摘 | Williams C Northstone K Harrad RA Sparrow JM Harvey I Air SPAC Study Team | 2003 | Br J Ophthalmol2003，87，8： | 1 |
| 13 | Intraocular lens formula constant optimization and partial coherence interferomet~ biometry: Refractive outcomes in 8108 eyes after cataract surgery 显示文摘 | Aristodemou P Knox CNE Sparrow JM | 2011 | J Cataract Refract Surg2011，37，1： | 1 |
| 14 | Use of vision tests in clinical decision making about cataract surgery: results of a national survey 显示文摘 | Frost NA Sparrow JM | 2000 | Can J Ophthalmol2000，874，4： | 1 |
| 15 | United Kingdom National Ophthalmology Database study of vitreoretinal surgery: report 2, macular hole 显示文摘 | Jackson TL Donachie PH Sparrow JM | 2013 | Ophthalmology2013，120，3： | 1 |
| 16 | Recovery of lcuko~enc E4 from the urine of patients with airway obs~uction 显示文摘 | Drazen JM O' Brien J Sparrow D ct al | 1992 | AM revrcspir Dis1992，146，1： | 1 |
| 17 | Clinical evaluation of frequency doubling technology perimetry using the Humphrey Matrix 24-2 threshold strategy显示文摘 | Spry PG Hussin HM Sparrow JM | 2005 | Br J Ophthalmol2005，89，： | 1 |
| 18 | Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism显示文摘AIM To evaluate the effects of the non-selective,non-steroidal anti-inflammatory drug(NSAID) acetylsalicylic acid(ASA),on ex vivo embryonic kidney growth and development. METHODS Pairs of fetal mouse kidneys at embryonic day 12.5 were cultured ex vivo in increasing concentrations of ASA(0.04-0.4 mg/m L) for up to 7 d. One organ from each pair was grown in control media and was used as the internal control for the experimental contralateral organ. In some experiments,organs were treated with ASA for 48 h and then transferred either to control media alone or control media containing 10 μmol/L prostaglandin E2(PGE2) for a further 5 d. Fetal kidneys were additionally obtained from prostaglandin synthase 2 homozygous null or heterozygous(PTGS2^(-/-) and PTGS2^(-/+)) embryos and grown in culture. Kidney cross-sectional area was used to determine treatment effects on kidney growth. Wholemount labelling to fluorescently detect laminin enabled crude determination of epithelial branching using confocalmicroscopy. RESULTS Increasing ASA concentration(0.1,0.2 and 0.4 mg/m L) significantly inhibited metanephric growth(P < 0.05). After 7 d of culture,exposure to 0.2 mg/m L and 0.4 mg/m L reduced organ size to 53% and 23% of control organ size respectively(P < 0.01). Addition of 10 μmol/L PGE2 to culture media after exposure to 0.2 mg/m L ASA for 48 h resulted in a return of growth area to control levels. Application of control media alone after cessation of ASA exposure showed no benefit on kidney growth. Despite the apparent recovery of growth area with 10 μmol/L PGE2,no obvious renal tubular structures were formed. The number of epithelial tips generated after 48 h exposure to ASA was reduced by 40%(0.2 mg/m L; P < 0.05) and 47%(0.4 mg/m L; P < 0.01). Finally,growth of PTGS2^(-/-) and PTGS2^(+/-) kidneys in organ culture showed no differences,indicating that PTGS2 derived PGE2 may at best have a minor role. CONCLUSION ASA reduces early renal growth and development but the role of prostaglandins in this may be minor. | Simon JM Welham Alexander J Sparrow David S Gardner Matthew J Elmes | 2017 | World Journal of Nephrology2017，6，1： | 0 |
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