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| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Analysis of Liver Repair Mechanisms in Alagille Syndrome and Biliary Atresia Reveals a Role for Notch Signaling显示文摘 | Luca Fabris Massimiliano Cadamuro Maria Guido Carlo Spirli Romina Fiorotto Michele Colledan Giuliano Torre Daniele Alberti Aurelio Sonzogni Lajos Okolicsanyi Mario Strazzabosco | 2007 | The American Journal of Pathology2007，，： | 2 |
| 3 | ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice显示文摘 | Spirli C Okolicsanyi S Fiorotto R | 2010 | Gastroenterology2010，138，1： | 1 |
| 4 | Proinflammatory cytokines inhibit secretion in rat bile duct epithelium显示文摘 | Spirli C Nathanson MH Fiorotto R | 2001 | Gastroenterology2001，121，1： | 1 |
| 5 | Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines显示文摘 | Zsembery A Spirli C Granato A | 1998 | Hepatology1998，28，： | 1 |
| 6 | Pathophysiology of the intrahepatic biliary epithelium显示文摘 | Strazzabosco M Spirli C Ololicsanyi L | 2000 | J Gastroenterol Hepatol2000，15，3： | 1 |
| 7 | Pathophysiology of cholangiopa- thies显示文摘 | Strazzabosco M Fabris L Spirli C | 2005 | J CAin Gastroenterol2005，39，42： | 1 |
| 8 | Proinflammatory cyto- kines inhibit secretion in rat bile duct epithelium 显示文摘 | Spirli C Nathanson MH Fiorotto R | 2001 | Gastroenterology2001，121，1： | 1 |
| 9 | Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice<!-- Doctopic: MCB -->显示文摘 | Romina Fiorotto Aileen Raizner Carola M. Morell Barbara Torsello Roberto Scirpo Luca Fabris Carlo Spirli Mario Strazzabosco | 2013 | Journal of Hepatology2013，，1： | 1 |
| 10 | Comparison of the probiotic characteristics of Lactic Acid Bacteria (LAB) isolated from sourdough and infant feces显示文摘Probiotics are beneficial microorganisms with certain characteristics such as survival under gastrointestinal conditions,adhesion to intestinal surface and different functions which result in several health benefits to host.With this regards,this study aimed to isolate Lactic Acid Bacteria (LAB) from sourdough and human feces as two different environments and to test their potential probiotic functions.In total nine distinct isolates were assessed with several probiotic functions such as in vitro adhesion to human colon cells,antimicrobial activities and survival under harsh gastrointestinal conditions.In general,distinct strains showed strong antimicrobial activity against the pathogenic and fungal strains tested in this study.Importantly,the adhesion levels to HT29 cells were determined between 0.29 % and 9.54% and Lactobacillus paracasei F7B showed the highest adhesion.All isolates tolerated the bile salt after 24 h and the infant feces isolates showed good survival characteristics at pH 4. | Yasemin Kaya Tayyibe Erten Melike Vurmaz Hümeyra İspirli Ömer Şimşek Enes Dertli | 2022 | Food Bioscience2022，47，3： | 1 |
| 11 | ERK1/2-dependent vascu- lar endothelial growth factor signaling sustains cyst growth in polycystin- 2 defective mice显示文摘 | Spirli C Okolicsanyi S Fiorotto R | 2010 | Gastroenterology2010，138，1： | 1 |
| 12 | Cyclic AMt'/PKA-dcpendent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defec- tive mice treated with Sorafenib显示文摘 | Spirli C Morell CM Locatelli L | 2012 | Hepatology2012，，： | 1 |
| 13 | Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice显示文摘 | SPIRLI C OKOLICSANYI S FIOROTTO R | 2010 | Hepatology2010，51，： | 1 |
| 14 | Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes 显示文摘 | Spirli C Fabris L Duner E | 2003 | Gastroenterology2003，124，3： | 1 |
| 15 | ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice显示文摘 | Carlo Spirli Stefano Okolicsanyi Romina Fiorotto Luca Fabris Massimiliano Cadamuro Silvia Lecchi Xin Tian Stefan Somlo Mario Strazzabosco | 2010 | Gastroenterology2010，，1： | 1 |
| 16 | Defective regulation of cholangiocyte CI^-/HCO^-3 and Na+/H+ exchanger activities in primary biliary cirrhosis 显示文摘 | Melero S Spirli C Zsembery A | 2002 | Hepatology2002，35，6： | 1 |
| 17 | Intercellular pH regulation in hep G2 cells: effects of epidermal growth factor, transforming growth factor -α, and insulinlike growth factor Ⅱ on Na+/H+ exchange activity显示文摘 | Strazzabosco M Poci C Spirli C | 1995 | Hepatology1995，22，2： | 1 |
| 18 | Proinflammatory cyto- kines inhibit secretion in rat bile duct epithelium 显示文摘 | Spirli C Nathanson MH Fiorotto R | 2001 | Gastroen- terology2001，12，1： | 1 |
| 19 | Defective regulation of cholangiocyte Cl-/HCO3-and Nat/Ht exchanger activities in primary biliary cirrhosis显示文摘 | MELERO S SPIRLI C ZSEMBERY A | 2002 | Hepatology2002，35，6： | 1 |
| 20 | Proinflammatory cytokines inhibit secretion in rat bile duct epithelium 显示文摘 | Spirli C Nathanson MH Fiorotto R | 2001 | Gastroenterology2001，121，1： | 1 |
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