|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Calreticulin and cancer显示文摘Calreticulin(CALR)is an endoplasmic reticulum(ER)-resident protein involved in a spectrum of cellular processes.In healthy cells,CALR operates as a chaperone and Ca^(2+)buffer to assist correct protein folding within the ER.Besides favoring the maintenance of cellular proteostasis,these cell-iintrinsic CALR functions support Ca^(2+)-dependent processes,such as adhesion and integrin signaling,and ensure normal antigen presentation on MHC Class I molecules.Moreover,cancer cells succumbing to immunogenic cell death(ICD)expose CALR on their surface,which promotes the uptake of cell corpses by professional phagocytes and ultimately supports the initiation of anticancer immunity.Thus,loss-of-function CALR mutations promote oncogenesis not only as they impair cellular homeostasis in healthy cells,but also as they compromise natural and therapy-driven immunosurveillanee.However,the prognostic impact of total or membrane-exposed CALR levels appears to vary considerably with cancer type.For instance,while genetic CALR defects promote pre-neoplastic myeloproliferation,patients with myeloproliferative neoplasms bearing CALR mutations often experience improved overall survival as compared to patients bearing wild-type CALR.Here,we discuss the context-dependent impact of CALR on malignant transformation,tumor progression and response to cancer therapy. | Jitka Fucikova Radek Spisek Guido Kroemerc Lorenzo Galluzzi | 2021 | Cell Research2021，31，1： | 12 |
| 2 | 'Borlezomib enhances dendritic cell (DC)-mediated induction of immunity to human myelo- ma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications显示文摘 | Spisek R Charalanfl3ous A Mazumder A | 2007 | Blood2007，109，11： | 1 |
| 3 | Extracorporeal photochemotherapy (ECP) in treatment of patients with c-GVHD and CTCL显示文摘 | Gasova Z Spisek R Dolezalova L | 2007 | Transfus Apher Sci2007，36，2： | 1 |
| 4 | Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells:therapeutic implications显示文摘 | SPISEK R CHARALAMBOUS A MAZUMDER A | 2007 | Blood2007，109，11： | 1 |
| 5 | Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graftversus-host disease显示文摘 | Spisek R Gasova Z Bartunkova J | 2006 | Transfusion2006，46，1： | 1 |
| 6 | Dendritic cells are specialized accessory cells along with TGF-P for the differen- tiation of Foxp3 + CD4 -I- regulatory T cells from peripheral Foxp3 precursors显示文摘 | Yamazaki S Bonito A J Spisek R | 2007 | Blood2007，110，13： | 1 |
| 7 | Maturation state of dendritic cells during theextracorporeal photopheresis and its relevance for the treatment of chronic graft versus-host disease显示文摘 | Spisek R Gasova Z Bartunkova J | | 0，，01： | 1 |
| 8 | Induction of leukemia - specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemie origin 显示文摘 | Spisek R Chevallier P Morineau N | 2002 | Cancer Res2002，62，10： | 1 |
| 9 | Dendritic cells are special- ized accessory cells along with TGF-13 for the differentiation of Foxp3+ CD4+ regulatory T ceils from peripheral Foxp3 precursors 显示文摘 | Yamazaki S Bonito A J Spisek R | 2007 | Blood2007，110，13： | 1 |
| 10 | Induction of leukemia-specific cytotoxic response by cross-presentation of late- apoptotic leukemic blasts by autologous dendritic ceils of nonleuke- mic origin 显示文摘 | SPISEK R CHEVALLIER P MORINEAU N | 2002 | Cancer Res2002，62，10： | 1 |
| 11 | Dendritic cel s are spe-cialized accessory cel s along with TGF for the differentiation of Foxp3+ CD4+ regulatory T cel s from peripheral Foxp3 precur-sors显示文摘 | Yamazaki S Bonito A J Spisek R | | 0，，13： | 1 |
| 12 | Immunotherapy perspectives in therapy of ovarian carcinomas 显示文摘 | Zapletalova K Tobiasova Z Spisek R | 2004 | Ceska Gynekol2004，69，5： | 1 |
| 13 | Assessment of lymphocyteproliferation: CFSE kills dividing cells and modulates expression ofactivation markers显示文摘 | Lastovicka J Budinsky V Spisek R | 2009 | Cellular Immunology2009，256，： | 1 |
| 14 | Role of teichoic acid choline moieties in the virulence of Streptococcus pneumoniae 显示文摘 | Gehre F Spisek R Kharat AS | 2009 | Infect Immun2009，77，7： | 1 |
| 15 | Bortczomibell hances dendritic cell (DC) mediated induction of immunity to hu man myeloma via exposure of cell surface heat shock protein 90 on dying lumor cells: lherapeutic implications显示文摘 | Spisek R CharalambousA Mazumder A | 2007 | Blood2007，09，24： | 1 |
| 16 | Immunotherapy perspectives in therapy of ovarian carcinomas显示文摘 | Zapletalova K Tobiasova Z Spisek R | 2004 | Ceska Gyneko2004，69，5： | 1 |
| 17 | Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin显示文摘 | Spisek R Chevallier P Morineau N | 2002 | Cancer Res2002，62，10： | 1 |
| 18 | Dendritic cells are specialized accessory cells along with TGF-for the differentiation of Foxp3+CD4+regulatory T cells from peripheral Foxp3 precursors显示文摘 | Yamazaki S Bonito AJ Spisek R | 2007 | {H}Blood2007，，13： | 1 |
| 19 | Bortezomib enhances dendritic cell(DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells:therapeutic implications显示文摘 | Spisek R Charalambous A Mazumder A | 2007 | Blood2007，109，11： | 1 |
| 20 | Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells:therapeutic implications显示文摘 | Spisek R Charalambous A Mazumder A | 2007 | Blood2007，109，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员