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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | An extremely sensitive species-specific ARMS PCR test for the presence of tiger bone DNA显示文摘 | Wetton J H Tsang C S F Roney C A Spriggs A C | 2002 | Forensic Science international2002，126，： | 2 |
| 3 | 4-Aminopyridine reverses saxitoxin (STX)- and tetrodotoxin (TTX)-induced cardiorespiratory depression in chronically instrumented guinea pigs显示文摘 | CHANG F T C SPRIGGS D L BENTON B J | 1997 | Fund Appl Toxico1997，38，1： | 1 |
| 4 | KOS-862 (Epethilone D):Phase Ⅰ dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies显示文摘 | Spriggs DR Dupont J Pezzulli S | 2003 | J Clin Oneol2003，22，： | 1 |
| 5 | Very low quality of life afteracute stroke : data from the Efficacy of Nitric Oxide in Stroke trial显示文摘 | Sprigg N Selby J Fox L | 2013 | Stroke2013，44，12： | 1 |
| 6 | Adolescent bullying in- volvement and perceived family, peer and school relations : commonal- ities and differences across race/ethnicity 显示文摘 | Spriggs A L Iannotti R J Nansel T R | 2007 | J Adolesc Health2007，41，3： | 1 |
| 7 | Incentive structures for food safety and quality assurance: an international comparison显示文摘 | HOBBS J E FEARNE A SPRIGGS J | 2002 | Food Control2002，，13： | 1 |
| 8 | Molecular characterization of the human interleukin- 17 receptor显示文摘 | Yao Z Spriggs M K Derry J M | 1997 | Cytokine1997，9，11： | 1 |
| 9 | Incentive structures for food safety and quality assurance: an international compari- son显示文摘 | Hobbs J E Fearne A Spriggs J | 2002 | Food Control2002，，13： | 1 |
| 10 | Semaphorin 7A promote axon outgrowth through integrins and MAPKs 显示文摘 | Pasterkamp RJ Peschon J J Spriggs MK | 2003 | Nature2003，424，6947： | 1 |
| 11 | Laser Damage Studies of 351 nm HR Silica-zirconia Sol Gel Coatings显示文摘 | Spriggs D M Andrew J E Bazin N J | 1997 | SPIE1997，2966，： | 1 |
| 12 | Investigation into the relationship be- tween the passive flexibility and active stiffness of the an- kle plantar-flexor muscles显示文摘 | Hunter DG Spriggs J | 2000 | Clinical Biomechanics2000，15，8： | 1 |
| 13 | Effect of the monetary macro-economy on Canadian agricultural prices显示文摘 | Taylor J S Spriggs J | 1989 | Can J Econ1989，22，： | 1 |
| 14 | Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion 显示文摘 | Spriggs M K Armitage R J Strockbine L | 1992 | J Exp Med1992，176，： | 1 |
| 15 | Is bed rest useful after di-agnostic lumbar puncture 显示文摘 | Spriggs DA Bum DJ French J | 1992 | Postgrad Med J1992，68，801： | 1 |
| 16 | Hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung cancer:an integrated analysis显示文摘 | Armstrong DK Spriggs D Levin J | 2005 | Oncologist2005，10，9： | 1 |
| 17 | Clinical Pharmacology of low-dose cytosine arabinoside显示文摘 | SPRIGGS D GRIFFIN J WISCH J | 1985 | Blood1985，65，： | 1 |
| 18 | Molecular characterization of the human interleukin (IL)-17 receptor显示文摘 | Yao Z Spriggs M K Derry J M | 1997 | Cytokine1997，9，11： | 1 |
| 19 | Ruminative thinking exacerbates the negative effects of workplace violence 显示文摘 | NIVEN K SPRIGG C A ARM1TAGE C J | 2013 | Journal of Occupational and Organizational Psychology2013，86，1： | 1 |
| 20 | Convulsions following axillary brachial plexus blockade with levobupivacaine显示文摘 | Pirotta D Sprigge J | 2002 | Anaesthesia2002，57，12： | 1 |
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