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| 1 | Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer显示文摘BACKGROUND The connection between inflammatory bowel disease(IBD)and colorectal cancer(CRC)is well-established,as persistent intestinal inflammation plays a substantial role in both disorders.Cytokines may further influence the inflammation and the carcinogenesis process.AIM To compare cytokine patterns of active IBD patients with early and advanced CRC.METHODS Choosing a panel of cytokines crucial for Th17/Treg differentiation and behavior,in colon specimens,as mRNA biomarkers,and their serum protein levels.RESULTS We found a significant difference between higher gene expression of FoxP3,TGFb1,IL-10,and IL-23,and approximately equal level of IL-6 in CRC patients in comparison with IBD patients.After stratification of CRC patients,we found a significant difference in FoxP3,IL-10,IL-23,and IL-17A mRNA in early cases compared to IBD,and IL-23 alone in advanced CRC.The protein levels of the cytokines were significantly higher in CRC patients compared to IBD patients.CONCLUSION Our findings showed that IL-6 upregulation is essential for both IBD and CRC development until the upregulation of other Th17/Treg related genes(TGFb1,IL-10,IL-23,and transcription factor FoxP3)is a crucial primarily for CRC development.The significantly upregulated IL-6 could be a potential drug target for IBD and prevention of CRC development as well. | Tsvetelina Veselinova Velikova Lyuba Miteva Noyko Stanilov Zoya Spassova Spaska Angelova Stanilova | 2020 | World Journal of Gastroenterology2020，26，16： | 10 |
| 2 | Interleukin-12B-3' UTR polymorphism in association with IL-12p40 and IL-12p70 serum levels and silicosis severity显示文摘 | STANILOVA S MITEVA L PRAKOVA G | 2007 | Int J Immunoganet2007，34，3： | 1 |
| 3 | Interleukin- 10 --1082 promoter polymorphism in association with cytokine production and sepsis susceptibility显示文摘 | Stanilova SA Miteva LD Karakolev ZT | 2006 | Intensive Care Med2006，32，2： | 1 |
| 4 | Genetic variation of TGF-BR2 as a protective genotype for the development of colorectal cancer in men显示文摘BACKGROUND The role of transforming growth factor beta(TGF-β)signaling,including both the cytokine and their receptors,in the etiology of colorectal cancer(CRC)has been of particular interest lately.AIM To investigate the association between promoter polymorphism in TGF-β receptor 2 TGF-BR2G^([-875])A with a CRC risk in a cohort of Bulgarian patients using a casecontrol gene association study approach,as well as the protein levels of TGF-β1 in the peripheral blood.METHODS A cohort of 184 CRC patients and 307 sex and age-matched healthy subjects were recruited in the study.A genotyping of the TGF-BR2G^([-875])A(rs3087465)polymorphism was performed by primer-introduced restriction analysespolymerase chain reaction approaches.RESULTS The frequency of TGF-BR2G^([-875])A genotype was decreased in male patients with CRC than in healthy men(31.3%vs 44.8%;P=0.058).Among males,the TGF-BR2G[-509]G genotype was related to a significantly increased risk of CRC development(OR=1.820,95%CI:0.985-3.362,P=0.055)than the GA+AA genotype.Also,TGF-BR2^([-875])*A-allele itself was rarer in men with CRC than healthy men(19.1%vs 26.9%,P=0.086)and was associated with a protective effect(OR=0.644;95%CI:0.389-1.066;P=0.086).Regarding the genotypes,we found that TGF-β1 serum levels were higher in GG genotype in healthy persons above 50 years than the CRC patients[36.3 ng/mL interquartile range(IQR)19.9-56.5 vs 22.4 ng/mL IQR 14.8-29.7,P=0.014].We found significant differences between higher levels of TGF-β1 serum levels in healthy controls above 50 years(GG genotype)and CRC patients(GG genotype)at the early stage(36.3 ng/mL IQR 19.9-56.5 vs 22.8 ng/mL IQR 14.6-28.6,P=0.037)and advanced CRC(36.3 ng/mL IQR 19.9-56.5 vs 21.6 ng/mL IQR 15.9-33.9,P=0.039).CONCLUSION In summary,our results demonstrated that TGF-BR2 AG and AA genotypes were associated with a reduced risk of CRC,as well as circulating levels of TGF-βcould prevent CRC development in a gender-specific manner.Notably,male carriers of TGF-BR2-875A allele genotypes had a lower risk of CRC development and progression,suggesting that TGF-BR2-875A/G polymorphism significantly affects the protective biological factors that also impact the risk of colon and rectal carcinogenesis. | Noyko Stanilov Antonia Grigorova Tsvetelina Velikova Spaska Angelova Stanilova | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 1 |
| 5 | Taq-I polymorphism in 3'UTR of the IL-12B and association with IL-12p4O production from human PBMC显示文摘 | Stanilova S Miteva L | 2005 | Genes Immun2005，6，： | 1 |
| 6 | IL-12B pro and GSTPL polymor- phisms in association with silicosis 显示文摘 | Stanilova S Miteva L Prakova G | 2008 | Tissue Antigens2008，71，2： | 1 |
| 7 | Interleukin-10-1082 pro- moter polymorphism in association with cytokine production and sepsis susceptibility显示文摘 | Stanilova SA Miteva LD Km'akolev ZT | 2006 | Intensive Care Med2006，32，2： | 1 |
| 8 | Cytokine production in thromboangiitis obliterans patients:new evidence for an immune-mediated inflammatory disorder显示文摘 | Slavov ES Stanilova SA Petkov DP | | 0，，： | 1 |
| 9 | IL--12Bpro and GSTPI polymorphisms in association with silicosis 显示文摘 | Stanilova S Miteva L Prakova G | 2008 | Tissue Antigens2008，71，2： | 1 |
| 10 | Associa-tion of +3179G/A insulin-like growth factor-1 receptorpolymorphism and insulin-like growth factor-1 serumlevel with systemic lupus erythematosus 显示文摘 | Stanilova S Ivanova M Karakolev I | 2013 | Lupus2013，22，13： | 1 |
| 11 | Association of single nucleotide polymorphism at position ?308 of the tumor necrosis factor-alpha gene with ankylosing spondylitis and rheumatoid arthritis显示文摘 | Irena Manolova Mariana Ivanova Rumen Stoilov Rasho Rashkov Spaska Stanilova | 2014 | Biotechnology & Biotechnological Equipment2014，，6： | 1 |
| 12 | Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility显示文摘 | Stanilova SA Miteva LD Karakolev ZT | 2006 | Intensive Care Med2006，32，2： | 1 |
| 13 | Association of + 3179G/A insulin-like growth factor-1 receptor poly- morphism and insulin-like growth factor-1 serum level with systemic lupus erythematosus 显示文摘 | Stanilova SA Ivanova MG Karakolev IA | 2013 | Lupus2013，22，13： | 1 |
| 14 | Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility 显示文摘 | Stanilova SA Miteva LD Karakolev ZT | 2006 | Intensive Care Med2006，32，2： | 1 |
| 15 | Hypotheses and facts for genetic factors related to severe COVID-19显示文摘Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe coronavirus disease 2019(COVID-19).Hence,it seems that genetics matters here,as well.Nevertheless,the virus's nature,including its RNA structure,determines the rate of mutations leading to new viral strains with all epidemiological and clinical consequences.Given these observations,we herein comment on the current hypotheses about the possible role of the genes in association with COVID-19 severity.We discuss some of the major candidate genes that have been identified as potential genetic factors associated with the COVID-19 severity and infection susceptibility:HLA,ABO,ACE2,TLR7,ApoE,TYK2,OAS,DPP9,IFNAR2,CCR2,etc.Further study of genes and genetic variants will be of great benefit for the prevention and assessment of the individual risk and disease severity in different populations.These scientific data will serve as a basis for the development of clinically applicable diagnostic and prognostic tests for patients at high risk of COVID-19. | Stanislav Vasilev Kotsev Dimitrina Miteva Stanislava Krayselska Martina Shopova Maria Pishmisheva-Peleva Spaska Angelova Stanilova Tsvetelina Velikova | 2021 | World Journal of Virology2021，10，4： | 0 |
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