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| 1 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 2 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 3 | Guidelines and critical pathways for severe hospital-acquired pneumonia显示文摘 | Stanley F | 2001 | Chest2001，119，： | 1 |
| 4 | Fast and slow dy- namics of hydrogen bonds in liquid water 显示文摘 | Starr F W Nielsen J K Stanley H E | 1999 | Phys Rev Lett1999，82，11： | 1 |
| 5 | Prophylaxis or treatment of experimental brucellosis with interleukin- 1 显示文摘 | Zhan Y F Stanley E R Cheers C | 1991 | Infect Immun1991，59，： | 1 |
| 6 | Location of sources of evoked scalp potentials: corrections for skull and scalp thicknesses显示文摘 | James P A Stanley A K Derek H F | 1981 | IEEE Transaction Biomedical Engineering1981，28，6： | 1 |
| 7 | An Empirical Study of Smoothing Techniques for Language Modeling显示文摘 | Stanley F Chen Joshua Goodman | 1996 | In proceedings of the 34th Annual Meeting of the ACL1996，，： | 1 |
| 8 | Ele- vated CO2 increases productivity and invasive species success in an arid ecosystem显示文摘 | STANLEY D S Travis E H Stephen F Z | 2000 | Nature2000，408，2： | 1 |
| 9 | Gravity model in the Korean highway显示文摘 | JungWS Wang F Stanley H E | 2008 | EPL Europhysics Letters2008，81，4： | 1 |
| 10 | Characterization of putative α-amylases from apple (Malus domestica) and Arabidopsis thaliana显示文摘 | Stanley D Fitzgerald A M Farnden K J F | | 0，，11： | 1 |
| 11 | Bolt-hole clearance effects and strength criteria in single-bolt, single-lap, composite bolted joints显示文摘 | MCCARTHY M A LAWLOR V P STANLEY W F | 2002 | Composite Science and Technology2002，62，1011： | 1 |
| 12 | The epidemiology of nephrotoxicity associated with conventional amphotericin B therapy显示文摘 | Stephan Harbarth Stanley L Pestotnik James F Lloyd John P Burke Matthew H Samore | 2001 | The American Journal of Medicine2001，，： | 1 |
| 13 | The use of sentinel infant mice for virus isolation 显示文摘 | Softly A Stanley N F | 1965 | Aust J Exp Biol Med Sci1965，43，17： | 1 |
| 14 | Effects of feeding milkreplacer once versus twice daily on glucose metabolism in Holstein and Jersey calves 显示文摘 | Stanley C C Williams C C Jenny B F | 2002 | Journal of Dairy Science2002，85，9： | 1 |
| 15 | Functional genomics显示文摘 | Stanley F Yuji David J L | 1999 | Proc Natl Acad Sci1999，96，： | 1 |
| 16 | Residual alveolar ridge main- tenance with a new endosseous implant material 显示文摘 | Stanley HR Hall MB Colaizzi F | 1987 | J Prosthet Dent1987，58，5： | 1 |
| 17 | Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages显示文摘 | Ginhoux F Stanley E R Samokhvalov I M | 2010 | Science2010，330，6005： | 1 |
| 18 | Effects of feeding milk replacer once versus twice daily on glucose metabolism in Holstein and Jersey calves显示文摘 | Stanley C C Williams C C Jenny B F | 2002 | Journal of Dairy Science2002，85，9： | 1 |
| 19 | Parallel MR ima-ging:a user' s guide显示文摘 | Glockner J F Hu HH Stanley DW | 2005 | Radiographics2005，25，： | 1 |
| 20 | Effects of feeding milk replace once versus twice daily on glucose metabolism in Holstein and Jersey calves 显示文摘 | STANLEY C C WILLIAMS C C JENNY B F | 2002 | Journal of dairy science2002，8，9： | 1 |
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