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| 1 | Advances in hepatitis C therapy: What is the current state-what come's next?显示文摘Chronic hepatitis C virus(HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease.It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin.However,treatment of HCV has undergone a revolutionary change in recent years.The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents(DAA).Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure.High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patients with liver cirrhosis,HCV-human immunodeficiency virus co-infections,after liver transplantion,or with chronic kidney disease comparable high rates of SVR can be achieved.The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or posttransplant patients.These 2nd generations DAAs will have higher resistance barriers,higher antiviral effects and a pan-genotypic spectrum.This review highlights the current state of the art of antiviral treatment in hepatitis Cand gives an outlook for upcoming therapies. | Steffen Zopf Andreas E Kremer Markus F Neurath Juergen Siebler | 2016 | World Journal of Hepatology2016，8，3： | 7 |
| 2 | Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding显示文摘BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent 'touch-free' agents.AIM To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI bleeding.Patients were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. | Francesco Vitali Andreas Naegel Raja Atreya Steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 3 | The human lumbar intervertebral disc:evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth,maturation,ageing,and degeneration显示文摘 | Steffen T Nelson F | 1996 | J Clin Invest1996，98，4： | 1 |
| 4 | Identification of acute myeloid leukaemia associated microRNA expression patterns 显示文摘 | Isken F Steffen B Merk S | 2008 | Br J Haematol2008，140，2： | 1 |
| 5 | Congenital Anomalies of the Coronary Arteries:Imaging with Ckontrastenhanced,Multidetector computed Tomography显示文摘 | Rainer S Steffen F Juergen B | 2005 | Eur Radiol2005，15，6： | 1 |
| 6 | Targeting of renal cell carcinoma with iodine-131-labelled chimeric monoclonal antibody G250显示文摘 | Steffens M G Corstens F H M Oosterwijik E | 1997 | J Clin Oncol1997，15，： | 1 |
| 7 | Insulin resist- ance: a proinflammatory state mediated by lipid-in- duced signaling dysfunction and involved in atheroscle- rotic plaque instability显示文摘 | Montecucco F Steffens S Mach F | 2008 | Mediators Inflamm2008，2008，： | 1 |
| 8 | Statins reduce interleukin-6-induced Creactive protein in human hepatocytes: new evidence for direct anti inflammatory effects of statins 显示文摘 | Arnaud C Burger F Steffens S | 2005 | Arterioscler Thromb Vasc Biol2005，25，6： | 1 |
| 9 | Identification of acute myeloid leukaemia associated microRNA expression patterns显示文摘 | Isken F Steffen B Merk S | 2008 | Br J Haematol2008，140，2： | 1 |
| 10 | High level expression of p27kipl and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27kipl and degree of malignancy in human breast and colorectal cancers 显示文摘 | Steffen F Jorges B Alistair MM | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 11 | In vitro effects of 2- methoxyestradiol on MCF-12A and MCF-7 cell growth,morpholo- gy and mitotic spindle formation 显示文摘 | Van Zijl C Lottering M L Steffens F | 2008 | Cell Biochem Funct2008，26，63： | 1 |
| 12 | Inflammation and atherosclerosis显示文摘 | Steffens S Mach F | 2004 | Herz2004，29，8： | 1 |
| 13 | C-reactive protein (CRP) induces chemokine secretion via CDllb/ ICAM-1 interaction in human adherent monocytes显示文摘 | Montecucco F Steffens S Burger F | 2008 | J Leukoc Biol2008，84，4： | 1 |
| 14 | Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma- a multicentre study显示文摘 | Steffens S Janssen M Roos F C | 2012 | Eur J Cancer2012，48，15： | 1 |
| 15 | The human lumbar intervertebral disc Evidence for change in the biosynthesis and denaturation of the extracellular matrix with growth maturation, aging and degeneration显示文摘 | ANTONIOU J STEFFEN T NELSON F | 1996 | J Clin Invest1996，98，4： | 1 |
| 16 | Tumor necrosis factor-alpha(TNF-alpha) induces integrin CD11b/CD18(Mac-1)up-regulation and migration to the CC chemokine CCL3 (MIP-1 alpha) on human neutrophils through defined signalling pathways显示文摘 | Ontecucco F Steffens S Burger F | 2008 | Cell Signal2008，20，3： | 1 |
| 17 | The specific role of chemo- kines in atherosclerosis 显示文摘 | Braunersreuther V Mach F Steffens S | 2007 | Thromb Haemost2007，97，5： | 1 |
| 18 | Kinetics of carbon mineralization of biochars compared with wheat straw in three soils 显示文摘 | Qayyum M F Steffens D Reisenauer H P | 2011 | Journal of Environmental Quality2011，41，4： | 1 |
| 19 | Best-case response times and jitter analysis of real-time tasks显示文摘 | Bril R J Steffens E F M Verhaegh W F J | 2004 | Journal of Scheduling2004，7，2： | 1 |
| 20 | Investigation of mathematical methods for efficient optimization of aqueous two-phase extraction显示文摘 | SELBER K NELLEN F STEFFEN B | 2000 | Journal of Chromatography B2000，，： | 1 |
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