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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 3 | Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study显示文摘 | Sten Nilsson Lars Franzén Christopher Parker Christopher Tyrrell René Blom Jan Tennvall Bo Lennern?s Ulf Petersson Dag C Johannessen Michael Sokal Katharine Pigott Jeffrey Yachnin Michael Garkavij Peter Strang Johan Harmenberg Bj?rg Bolstad ?yvind S Brula | 2007 | Lancet Oncology2007，，7： | 1 |
| 4 | Exploring the two-gene ratio in breast cancer—independent roles for HOXB13 and IL17BR in prediction of clinical outcome显示文摘 | Piiha-Lotta Jerevall Sara Brommesson Carina Strand Sofia Gruvberger-Saal Per Malmstr?m Bo Nordenskj?ld Sten Wingren Peter S?derkvist M?rten Fern? Olle St?l | 2007 | Breast Cancer Research and Treatment2007，，2： | 1 |
| 5 | Risk factors for infection of sow herds with porcine reproductive and respiratory syndrome (PRRS) virus显示文摘 | Sten M Henrik S Rikke S | 2002 | Prevent Vet Med2002，14，12： | 1 |
| 6 | Risk factors for infection of sow herds with poreine reproductive and respiratory syndrome (PRRS) vires 显示文摘 | Sten M Henrik S Rikke S | 2002 | Prevent Vet Med2002，14，12： | 1 |
| 7 | Short course adjuvant chemotherapy in high risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report 显示文摘 | Cullen M H Stenning S P Parkinson M C | 1996 | J Clin Oncol1996，14，： | 1 |
| 8 | Cytokines and osteolysis around total hip prostheses显示文摘 | Sten S Visentin M Granehi D | | 0，，： | 1 |
| 9 | Pharmacovigilance activities in 55low-and middle-income countries显示文摘 | Sten O Shanthi N P Andy S | 2010 | Drug safety2010，33，8： | 1 |
| 10 | High-dose versus conventional-dose chemotherapy as first-salvage treatment in patients with non-seminomatous germ-cell tumors:a matched-pair analysis显示文摘 | Beyer J Stenning S Gerl A | 2002 | Ann Oncol2002，13，4： | 1 |
| 11 | A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma显示文摘 | Bleehen N M Stenning S P | 1991 | Br J Cancer1991，64，4： | 1 |
| 12 | Basal serum land reactivity of nerve growth factor and braiwderived neurotro- phic factor to standardized acute exercise in multiple sclerosis and controls 显示文摘 | Stefan MG Karl Heinz S Sten H | 2003 | J Neuroimmunol2003，138，12： | 1 |
| 13 | Risk factors for infection of sow herds with porcine reproductive and respiratory syndrome (PRRS) virus显示文摘 | Sten M Henrik S Rikke S | 2002 | Prevent Vet Med2002，14，12： | 1 |
| 14 | Primary habitual abortions are associated with high frequency of Factor V Leiden mutation显示文摘 | Wramsby M L Sten L S Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 15 | Hypofractionated radiotherapy for poor prognosis malignant glioma:matched pair survival analysis with MRC controls显示文摘 | McAleese J J Stenning S P Ashley S | 2003 | Radiother Oncol2003，67，2： | 1 |
| 16 | Primary habitual abortions are associated with high frequency of Factor V Leiden mutation显示文摘 | Wramsby M L Sten L S Bremme K | 2000 | Fertil Steril2000，74，5： | 1 |
| 17 | Temozolomide versus procarbazine , lomustine, and vincristine in recurrent high- grade glioma显示文摘 | Brada M Stenning S Gabe R | 2010 | J Clin Oncol2010，28，30： | 1 |
| 18 | perioperative chemotherapy versus surgery alone for respectable gastroesophageal cancer 显示文摘 | CUNNINGHAM D ALLUM W H STENNING S P | 2006 | N Engl J Med2006，355，1： | 1 |
| 19 | Neuroendocrine differentiation and clinical behaviour in non-small cell lung tumours显示文摘 | Sundaresan V Reeve JG Stenning S | 1991 | Br J Cancer1991，64，2： | 1 |
| 20 | Temozlomide versus procar-bazine’Iomustine,and vincristine in recurrent high-grade glioma显示文摘 | Brada M Stenning S Gabe R | 2010 | J Clin Oncol2010，28，30： | 1 |
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