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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Short course adjuvant chemotherapy in high risk stage I nonseminomatous germ cell tumors of the testis: a Medical Research Council report 显示文摘 | Cullen M H Stenning S P Parkinson M C | 1996 | J Clin Oncol1996，14，： | 1 |
| 3 | Pharmacovigilance activities in 55low-and middle-income countries显示文摘 | Sten O Shanthi N P Andy S | 2010 | Drug safety2010，33，8： | 1 |
| 4 | A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma显示文摘 | Bleehen N M Stenning S P | 1991 | Br J Cancer1991，64，4： | 1 |
| 5 | Hypofractionated radiotherapy for poor prognosis malignant glioma:matched pair survival analysis with MRC controls显示文摘 | McAleese J J Stenning S P Ashley S | 2003 | Radiother Oncol2003，67，2： | 1 |
| 6 | perioperative chemotherapy versus surgery alone for respectable gastroesophageal cancer 显示文摘 | CUNNINGHAM D ALLUM W H STENNING S P | 2006 | N Engl J Med2006，355，1： | 1 |
| 7 | A short fractionation radiotherapy for poor prognosis patients with high-grade glioma显示文摘 | Ford J M Stenning S P Boote D J | 1997 | Clin Oncol1997，9，1： | 1 |
| 8 | Determination of chemicals bound to mineral surfaces in flotation processes显示文摘 | Miettinen M Sten P Backman S | 2000 | Minerals Engineering2000，13，3： | 1 |
| 9 | Approximation of continuous discontinous functions by generatized sampling series显示文摘 | Butzer P L Ries S Stens R L | 1987 | J Approx Theory1987，，50： | 1 |
| 10 | Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice 显示文摘 | Xinghua Z Gabrielle P Sten S | 1998 | Clin Invest1998，101，6： | 1 |
| 11 | Pharmacovigilance activities in 55 low-and middle-income countries显示文摘 | STEN O SHANTHI N P ANDY S | 2010 | Drug Safety2010，33，8： | 1 |
| 12 | Perioperative chemotherapy in operable gastric and lower oesophageal cancer: final results of a randomised, controlled trial显示文摘 | Cunningham D Allum W H Stenning S P | 2005 | J Clin Oneol2005，23，16： | 1 |
| 13 | Pefioperative chem- otherapy versus surgery alone for resectable gastroesophageal cancer 显示文摘 | Cunningham D Allum W H Stenning S P | 2006 | N Engl J Meal2006，355，1： | 1 |
| 14 | Perioperative chemotherapy in operable gastric and lower oesophageal cancer: final results of a randomized, controlled trial (the MAGIC trail, ISRCTN 93793971) 显示文摘 | CUNNINGHAM D ALLUM W H STENNING S P | 2005 | J Clin Oncol2005，23，16： | 1 |
| 15 | Perio-perative chemotherapy versus surgery alone for resectablegastroesophageal cance 显示文摘 | Cunningham D Allum W H Stenning S P ei al | 2006 | N Engl J Med2006，355，1： | 1 |
| 16 | Periopera- tive chemotherapy versus surgery alone for resectable gastroe- sophagea:caneer显示文摘 | Cunningham D Allum W H Stenning S P etal | 2006 | N EnglJ Med2006，355，： | 1 |
| 17 | Long-term re- suits of a randomized trial of surgery with or without preopera- tive chemotherapy in esophageal cancer 显示文摘 | Allum W H Stenning S P Bancewicz J | 2009 | J CIin Oncol2009，27，30： | 1 |
| 18 | A medical research council trail of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma显示文摘 | Bleehen N M Stenning S P | 1991 | Br F Cancer1991，64，4： | 1 |
| 19 | Middle east respiratory syndrome corona- virus (reefs-coy): Announcement of the coronavirus studygroup显示文摘 | de Groot R J Baker S C Baric R S Brown C S Dro- sten C Enjuanes L Fouchier R A Galiano M Gor- balenya A E Memish Z A Perlman S Poon L L Sni- jder E J Stephens G M Woo P C Zaki A M ZambonM Ziebuhr J | 2013 | J Virol2013，87，14： | 1 |
| 20 | Long-termresults of a randomized trial of surgery with or without preoperativechemo-therapy in esophageal cancer显示文摘 | ALLUM W H STENNING S P BANCEWICZ J | 2009 | J Clin Oncol2009，27，： | 1 |
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