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3篇 您的检索式:作者名="Stephan Immenschuh"
    题名 作者 年代 出处 被引量
1Heme oxygenase-1 as a therapeutic target in inflammatory disorders of the gastrointestinal tract显示文摘Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of heme degradation. HO-1 not only protects against oxidative stress and apoptosis, but has received a great deal of attention in recent years because ofits potent anti-inflammatory functions. Studies with HO-1 knockout animal models have led to major advances in the understanding of how HO-1 might regulate inflammatory immune responses, although little is known on the underlying mechanisms. Due to its beneficial effects the targeted induction of this enzyme is considered to have major therapeutic po- tential for the treatment ofinflammatory disorders. This review discusses current knowledge on the mechanisms that mediate anti-inflammatory protection by HO-1. More specifically, the article deals with the role of HO-1 in the pathophysiology of viral hepatitis, inflammatorybowel disease, and pancreatitis. The effects of specific HO-1 modulation as a potential therapeutic strategy in experimental cell culture and animal models of these gastrointestinal disorders are summarized. In conclusion, targeted regulation of HO-1 holds major promise for future clinical interventions in inflammatory diseases of the gastrointestinal tract.Vijith Vijayan Sebastian Mueller Eveline Baumgart-Vogt Stephan Immenschuh 2010World Journal of Gastroenterology2010,16,25:13
2Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential显示文摘Ananta Paine Britta Eiz-Vesper Rainer Blasczyk Stephan Immenschuh 2010Biochemical Pharmacology2010,,:2
3SJWD14081800000616显示文摘Laura Schlahsa HaiJiao Zhang Anja Battermann Murielle Verboom Stephan Immenschuh Britta Eiz‐Vesper Renata Stripecke Katrin Engelmann Rainer Blasczyk Constan?a Figueiredo 2014Transfusion2014,,8:1
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