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3篇 您的检索式:作者名="Stephen Gibbons"
    题名 作者 年代 出处 被引量
1在心血管的疾病的先进 glycation 结束产品的角色显示文摘 Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus(DM).AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modif ication of the structure,function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs(RAGE)].A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure(HF).Moreover,some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF.The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure,focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF.Zeinab Hegab Stephen Gibbons Ludwig Neyses Mamas A Mamas 2012World Journal of Cardiology2012,4,4:58
2School quality, child wellbeing and parents' satisfaction 显示文摘Stephen Gibbons Olmo Silva 2011Economics of Education Review2011,,30:1
3Rail Access and House Prices:An Evaluation of the Wider Benefits of Transport Improvements显示文摘 2003The Centre for Economic Performaace at the London School of Economics2003,2003,:1
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