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3篇 您的检索式:作者名="Stephen Sheehan"
    题名 作者 年代 出处 被引量
1Determination of arrhythmic death due to coronary spasm:effort of preexisting coronary artery stenosis on the incidence of reperfusion arrhythmia显示文摘Florence H Sheehan Stephen E 1982Circulation1982,65,2:1
2Dynamic epi-transcriptomic landscape mapping with disease progression in estrogen receptor-positive breast cancer显示文摘Dear Editor,The molecular determinants that drive breast cancer progression to metastasis are complex and partly controlled by nucleic acid epi-modifications[1].Although DNA-methyl modifications in breast cancer metastasis have been well described,there is limited understanding of the role of RNA methylation in advanced disease[2].This study aimed to provide an understanding on the role of the epitranscriptome in estrogen receptor-positive(ER+)breast cancer progression to metastasis.Stephen Keelan Mihaela Ola Sara Charmsaz Sinéad Cocchiglia Daniela Ottaviani Seán Hickey Siobhan Purcell Fiona Bane Aisling Hegarty Ben Doherty Katherine Sheehan Lance Hudson Nicola Cosgrove Benjamin Roux Muriel Laine Geoffrey Greene Damir Varešlija Arnold Konrad Hill Leonie Young 2023Cancer Communications2023,43,5:0
3Resection and reconstruction of pelvic and extremity soft tissue sarcomas with major vascular involvement: Current concepts显示文摘Soft tissue sarcoma accounts for approximately 1% of all cancers diagnosed annually in the United States. When these rare malignant mesodermal tumours arise in the pelvis and extremities, they may potentially encase or invade large calibre vascular structures. This presents a major challenge in terms of safe excision while also leaving acceptable surgical margins. In recent times, the trend has been towards limb salvage with vascular reconstruction in preference to amputation. Newer orthopaedic and vascular reconstructive techniques including both synthetic and autogenous graft reconstruction have made complex limb-salvage surgery feasible. Despite this, limb-salvage surgery with concomitant vascular reconstruction remains associated with higher rates of post-operative complications including infection and amputation. In this review we describe the initial presentation and investigation of patients presenting with soft tissue sarcomas in the pelvis and extremities, which involve vascular structures. We further discuss the key surgical reconstructive principles and techniques available for the management of these complex tumours, drawn from our institution's experience as a national tertiary referral sarcoma service.Niall P Mc Goldrick Joseph S Butler Maire Lavelle Stephen Sheehan Sean Dudeney Gary C O'Toole 2016World Journal of Orthopedics2016,7,5:0
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