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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Non-surgical management of live ectopic pregnancy with ultrasound-guided local injection :a case series显示文摘 | Monteagudo A Minior VK Stephenson C | 2005 | Ultrasound Obstet Gynecol2005，25，3： | 1 |
| 3 | Inhibition of rous scrcoma virus replication and cell transformation by a specific oligodeoxymucleotide显示文摘 | Zameenik P C Stephenson M L | 1978 | Proc Natl Acad Sci USA1978，75，1： | 1 |
| 4 | Estimating the insertion site daring retrograde intramedullary tibiotaloealeaneal arthrodesis 显示文摘 | Stephenson K A Kile T A Graves S C | 1996 | Foot Ankle Int1996，17，12： | 1 |
| 5 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 6 | Laparoscopic pancreatic surgery: a review of present results and future prospects 显示文摘 | A1-Taan OS Stephenson JA Briggs C | 2010 | HPB2010，12，4： | 1 |
| 7 | Effect of weightlifting upon left ventricular function and markers of cardiomyocyte damage 显示文摘 | Stephenson C McCarthy J | 2005 | Ergonmnics2005，48，1114： | 1 |
| 8 | High-resolution ^13C CP/MAS NMR spectra of solid cellulose oligomers and the structure of cellulose II显示文摘 | DUDLEY R L FYFE C A STEPHENSON P J | 1983 | Journal of the American Chemical Society1983，105，8： | 1 |
| 9 | Quantitative trait loci affecting PrP incubation time in mice显示文摘 | STEPHENSON D CHIOTTI K EBELING C | 2000 | Genomics2000，69，1： | 1 |
| 10 | Singlestage anaerobic/aerobic biotreatment of resin acid-containing wastewater 显示文摘 | Guiot S R Stephenson R J Frigon J C | 1998 | Water Sci Technol1998，38，4： | 1 |
| 11 | Adverse events associated with methimazole therapy of Graves' disease in children 显示文摘 | Rivkees SA Stephenson K Dinauer C | 2010 | Int J Pediatr Endocrino12010，2010，17： | 1 |
| 12 | Compliance with antidepressant medication in the treatment of majored pressive disorder primarycare:arandomized comparison of fluoxetine and tricyciic antidepressant显示文摘 | Thompson C Peveler RC Stephenson D | 2000 | American Journal of Psychiatry2000，，5： | 1 |
| 13 | Laparoscopic pancre-atic surgery : a review of present results and future prospects 显示文摘 | Al-Taan OS Stephenson JA Briggs C | 2010 | HPB (Oxford)2010，12，4： | 1 |
| 14 | A femtojoule calorimeter using micromechanical sensors 显示文摘 | Barnes J R Stephenson R J Woodburm C N | 1994 | Review of Scientific Instruments1994，65，12： | 1 |
| 15 | Adverse events associ- ated with methimazole therapy of Graves' disease in children 显示文摘 | Rivkees SA Stephenson K Dinauer C | 2010 | Int J Pediatr Endocrinol2010，2010，： | 1 |
| 16 | Laparoscopic pancreatic surgery: a review of present results and future prospects显示文摘 | A1-Taan O S Stephenson J A Briggs C | 2010 | Hpb the Official Journal of the International Hepato Pancreato Biliary Association2010，12，4： | 1 |
| 17 | Trastuzumab in the Treatment of Advanced Non-Small-Cell Lung Cancer:Is There a Role? Focus on Eastern Cooperative Oncology Group Study 2598显示文摘 | Langer C J Stephenson P Thor A | 2004 | Clin Oncol2004，22，7： | 1 |
| 18 | Inhibition of Rous sarcoma virus replication and transformation by a specific oligodeoxynucleotide显示文摘 | ZAMECNIK P C STEPHENSON M L | 1978 | Proc Natl Acad Sci USA1978，75，1： | 1 |
| 19 | Nutrient bioassimilation capacity of aquacultured oysters: quantification of an ecosystem service显示文摘 | Higgins C B Stephenson K Brown B L | 2011 | Journal of Environmental Quality2011，40，1： | 1 |
| 20 | Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide 显示文摘 | STEPHENSON M L ZAMECNIK P C | 1978 | Proc Natl Acad Sci USA1978，75，1： | 1 |
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