|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 3 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 4 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Host plant resistance to blackmargined aphids on pecan显示文摘 | Tommy E T Grauke L J Steven G S | 2000 | Journal American Pomological Society2000，54，4： | 1 |
| 7 | Atrazine:Mechanisms of hormonal imbalance in female SD rats显示文摘 | Chapin R E Stevens J T Hughes C L | 1996 | Funda Appl Toxicol1996，29，： | 1 |
| 8 | Atrazine: Mechanisms of hormonal imbalance in female SD rats 显示文摘 | Chapin R E Stevens J T Hughes C L | 1996 | Funda Appl Toxicol1996，29，： | 1 |
| 9 | Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus显示文摘 | Blixt O Tumpey T M | 2006 | Science2006，312，： | 1 |
| 10 | Development of a statewide col- laborative to decrease NICU central line-associated bloodstream infec- tions 显示文摘 | Schulman J Stricof R Stevens T | 2009 | J Perinatol2009，29，： | 1 |
| 11 | Lithoautotrophic microbial ecosystem in deep basalt aquifers 显示文摘 | Steven T O McMkinley J P | 1995 | Science1995，270，5235： | 1 |
| 12 | The proto- toxin lynxl acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo显示文摘 | Miwa J M Stevens T R King S L | 2006 | Neu- ron2006，51，5： | 1 |
| 13 | Process requirements for achieving full-flow disinfection of recirculating water using ozonation and UV irradiation 显示文摘 | STEVEN T S MARK J S SCOTT M T | 2009 | Aquacuhural Engineering2009，40，1： | 1 |
| 14 | Assessing kidney function:measured and estimated glomerular filtration rate显示文摘 | Stevens LA Coresh J Greene T | 2006 | N Engl J Med2006，354，： | 1 |
| 15 | Temozolomide:mechanisms of action,repair and resistance显示文摘 | Zhang J Stevens M F Bradshaw T D | 2012 | Curr Mol Pharmacol2012，5，1： | 1 |
| 16 | Perinatal hepati- tis b virus transmission in the United States:prevention by passive - active immunization 显示文摘 | Stevens C E Toy P T Tong M J | 1985 | JAMA1985，253，13： | 1 |
| 17 | Sedimentation and aliagenesis of Chinese loess: implications for the preservation of continuous high-resolution climate records显示文摘 | Stevens T Armitage S J Lu H | 2006 | Geology2006，34，： | 1 |
| 18 | High resolution derivative spectra in remote sensing 显示文摘 | DEMETRIADES-SHAH T H STEVEN M D CLARK J A | 1990 | Re- mote Sensing of Environment1990，33，1： | 1 |
| 19 | High resolution derivative spectra显示文摘 | Demetriades S T H Steven M D Clark J A | 1990 | Remote Sensing Environ1990，33，： | 1 |
| 20 | High spectral resolution data for determining leaf water content 显示文摘 | F M Danson M D Steven T J Malthus | 1992 | International Journal of Remote Sensing1992，13，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员