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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 3 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 4 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Ontogeny of me- tabolizing enzymes in the neonate 显示文摘 | MICHAEL J B LISA C B J STEVEN L | 2005 | Semin Fetal Neonatal Med2005，10，2： | 1 |
| 7 | Kinetic and thermodynamic aspects of sodium-coupled amino acid transport by marine invertebrates显示文摘 | Preston R L Stevens B R | 1982 | Am Zool1982，22，： | 1 |
| 8 | Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK During Apoptosis in Renal Epithelial Cells显示文摘 | van de WATER B NAGELKERKE J F STEVENS J L | 1999 | J Biol Chem1999，274，13： | 1 |
| 9 | Comparisonof minimally invasive and conventional open posterolateral lum-bar fusion using magnetic resonance imaging and retractionpressure studies 显示文摘 | Stevens K J Spenciner D B Griffiths K L | 2006 | J Spinal Disord Tech2006，2，1： | 1 |
| 10 | Common variation in Nemo-like kinase is associated with risk of ovarian cancer显示文摘 | Stevens K N Kelemen L E Wang X Fridley B L Vierkant R A Fredericksen Z | 2012 | Cancer Epidemiol Biomarkers Prev2012，21，： | 1 |
| 11 | Characterization of isomeric sulfonamides using capilary zone exlectrophoresis coupled with nano-electrospray quasi-MS-MS-MS显示文摘 | Kevin P B Steven J L Dietrich A V | 1997 | J Mass Spectrom1997，，32： | 1 |
| 12 | Phytosiderophore release from nodal,primary,and complete root systems in maize显示文摘 | Bernards M L Jolley V D Stevens W B | 2002 | Plant Soil2002，241，1： | 1 |
| 13 | Effect of stacking sequence on micro-cracking in a cryogenically cycled carbon/ bismaleimide composite 显示文摘 | Bethel V T Mark B F Steven L D | 2003 | Composites: Part A2003，34，7： | 1 |
| 14 | Characterization of the intesti- nal microbiota of two Antarctic notothenioid fish species 显示文摘 | Ward N L Steven B Penn K | 2009 | Ex- tremophiles2009，13，4： | 1 |
| 15 | Map-based cloning of leaf rust resistance gene Lr21 from the large and polyploid genome of bread wheat显示文摘 | Huang L Steven A B Li W L | 2003 | Genetics2003，164，： | 1 |
| 16 | Enzymatic production of protein hy- drolysates for food use显示文摘 | WILLIAM J L STEVEN D B | 1994 | Food Teehnol1994，48，10： | 1 |
| 17 | Specific and genotypic identification of Cryptosporidium from a broad range of host species by nonisotopic SSCP analysis of nuclear ribosomal DNA显示文摘 | Xiao L Stevens M Gasser R B | 2007 | Electrophoresis2007，28，16： | 1 |
| 18 | Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor显示文摘 | Roni L Steven D Smith B | 2000 | Am J Physiol Cell Physio2000，278，5： | 1 |
| 19 | Analysis of high-dispersion tracer tests in cores containing polymer gels显示文摘 | Aniello M Steven L B Thomas P L | 1999 | Journal of Petrole-um Science and Engineering1999，，23： | 1 |
| 20 | Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics显示文摘 | Kari L Steven DB Harry B Juha R Jutta H Harry S | 2004 | Eur J Clin Pharmacol2004，59，： | 1 |
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