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| 1 | Improved hemostasis with major hepatic resection in the current surgical era显示文摘Background: Major hepatic resection, predominantly performed for oncologic intent, is a complex procedure with the potential for severe intraoperative hemorrhage. The current surgical era has the ability to improve hemostasis throughout the performance of major hepatic resections which decreases blood transfusions and the detrimental effects associated with transfusion. We evaluated hemostasis and outcomes in the current surgical era of performing hepatic resections. Methods: Utilizing the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database all major hepatic resections performed between 2012 and 2016 were analyzed in regards to hemostasis. Hemostasis was evaluated by the need for and magnitude of blood transfusions. Additional perioperative variables (including operative time, length of hospital stay, and mortality rates) were analyzed to assess for outcomes with hemostasis. The NSQIP results were compared to previous publications involving major hepatic resections to detect improvement in hemostasis and outcomes in the current surgical era. Results: A total of 22777 major hepatic resections met the inclusion criteria for analysis in the NSQIP database. An additional 21198 cases were compiled within the selected publications for comparative analysis. The transfusion rate in the current surgical era was 13.3% versus 38.7% in the previous era ( P = 0.0001). When a transfusion was required in the current surgical era there was a two-fold reduction in the number of units transfused (1.5 U vs. 3.8 U, P = 0.0001). Statistically significant improvements in operative time and length of hospital stay were presented within the current surgical era ( P = 0.0001). When a transfusion was required there was an increased relative risk score of 7 for mortality (4.9% vs. 0.7%, P = 0.0001), however, improvement in mortality rates did not reach statistical significance across surgical eras (1.3% vs. 4.0%, P = 0.0001). Conclusions: The conduction of major hepatic resection in the current surgical era is more hemostatic. Correlated with improved hemostasis are better outcomes for both clinical and financial endpoints. These findings should encourage continued and increased performance of major hepatic resections. | Christopher W Mangieri Matthew A Strode Bradley C Bandera | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 2 | Supercritical fluid chromatography of Ginkgolide A,B,C and J and bilobalide显示文摘 | Strode T B Taylor L T Van Beek T A | 1996 | J Chromatogr A1996，738，： | 2 |
| 3 | Supercritieal fluid chromatography of ginkgolides A, B, C, and J and bilobalide显示文摘 | J Thomposon B Strode III Larry T Taylor Teris A Van Beek | 1996 | J Chromatogr A1996，738，： | 1 |
| 4 | Technical and clinical progress in telemedicine显示文摘 | Strode SW Gustke S Allen A | 1999 | JAMA1999，281，12： | 1 |
| 5 | Feasibility of lovastatin analysis by packed column supercritical fluid chromatography with ultraviolet detection显示文摘 | Strode J T B Taylor L T HOWARD A L | 1999 | J Pharm Biomed Anal1999，20，： | 1 |
| 6 | Preimplantation diagnosis to create ' saviour siblings': a critical discussion of the current and future legal frameworks in South Africa 显示文摘 | Strode A Soni S | 2011 | S Afr Med J2011，102，1： | 1 |
| 7 | Air-sea exchange in the global mercury cycle显示文摘 | Strode S A Jaegle L Selin N E | 2007 | Global Biogeochemical Cycles2007，21，： | 1 |
| 8 | Vertical transport of anthropogenic mercury in the ocean显示文摘 | Strode S A Jaegle L Emerson S | 2010 | Global Biogeochemical Cycles2010，24，： | 1 |
| 9 | Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria显示文摘 | AWOLOLA T S ODUOLA O A STRODE C | 2009 | Trans R Soc Trop Med Hyg2009，103，11： | 1 |
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