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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 3 | Steroid hormone influence on brain calbindin-D28k in male prepubertal and ovariectomized rats显示文摘 | Stuart E B Thompson J M Rhees R W | 2001 | Developmental Brain Research2001，129，2： | 1 |
| 4 | When do scientists become entrepreneurs? The social structural antecedents of commercial activity in the academic life sciences显示文摘 | Stuart T E Ding W W | | 0，，01： | 1 |
| 5 | The Social structural antecedents of commercial activity in the academic life science 显示文摘 | STUART T E DING W W | 2006 | American Journal of Sociology2006，12，1： | 1 |
| 6 | Density- dependent fitness benefits in quorum-sensing bacterial populations 显示文摘 | Sophie E D Stuart A W Klaus W | 2012 | Pans2012，109，22： | 1 |
| 7 | A Program of Classical Condi-tioning Experiments Testing Variations in the Conditioned Stimulusand Context显示文摘 | Shimp T A Stuart E W Engle R W | 1991 | Journal of Consumer Research1991，18，1： | 1 |
| 8 | Gender differences in patenting in the academic life sciences显示文摘 | DING W W MURRAY F STUART T E | 2006 | Science2006，313，7： | 1 |
| 9 | When do scientists become entrepreneurs? The social antecedents of commercial activity in the academic life sciences 显示文摘 | Stuart T E Ding W | 2006 | American Journal of Sociology2006，112，1： | 1 |
| 10 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 11 | Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies显示文摘 | Scott W R Stuart N B Jennifer E R | 1998 | The Journal of Biological Chemistry1998，273，9： | 1 |
| 12 | Tethered polymer chains: surface chemistry and their impact on colloidal and surface properties 显示文摘 | Currie E P K Norde W Cohen Stuart M A | 2003 | Advances in Colloid and Interface Science2003，，100102： | 1 |
| 13 | Vertical alliance network: The case of University-Biotechnology-Pharmaceutical alliance chains显示文摘 | Stuart T E Ozdemir S Z Ding W W | 2007 | Research Policy2007，，5： | 1 |
| 14 | Tethered polymer chains: surface chemistry and their impact on colloidal and surface properties 显示文摘 | Currie E P Norde W Cohen Stuart M A | 2003 | Advances in Colloid and Interface Science2003，100，： | 1 |
| 15 | Vertical alliance network: the case of university - biotechnology - phar- maceutical alliance chains显示文摘 | Stuart T E Ozdemir S Z Ding W W | 2007 | Research Policy2007，，5： | 1 |
| 16 | Optimizing post-combustion CO2 capture in response to volatile electricity prices显示文摘 | Stuart M C Gary T R Michael E W | 2012 | International Jonmal of Greenhouse Gas Control2012，8，0： | 1 |
| 17 | Radar Cross Section Handbook (Volume 2) 显示文摘 | Ruck G T Barrick D E Stuart W D | 1970 | New York: Plenum1970，，： | 1 |
| 18 | Lost in Cyberspace : Barriers to Bridging the Digital Divide in E - Politics 显示文摘 | SHELLEY MACK C THRANE LISA E SHULMAN STUART W | 2004 | Internet and Enterprise Management2004，4，3： | 1 |
| 19 | Auditor concentration and market share in the US:1988-1999显示文摘 | Wolk C M Stuart E M Charles W W | 2001 | British Accounting Review2001，，1： | 1 |
| 20 | When do scientists become entrepreneurs? The social antecedents of commercial activity in the academic life sciences显示文摘 | Stuart T E Ding W | 2006 | Americal Journal of Sociology2006，112，1： | 1 |
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