|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of species-dependent hydrolysis and protein binding of esmolol enantiomers显示文摘The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>rabbit>human.Rat plasma showed the high esterase activity and had no stereoselectivity to enantiomers.Rabbit red blood cell(RBC) membrane,RBC cytosol and plasma all hydrolyzed esmolol but with different esterase activity,whereas the hydrolysis in RBC membrane and cytosol showed significant stereoselectivity towards R-(+)-esmolol.Esterase in RBC cytosol from human blood mainly contributed to the esmolol hydrolysis,which was demonstrated with no stereoselctivity.Esterase in human plasma showed a low activity,but a remarkable stereoselectivity with R-(+)-esmolol.In addition,the protein concentration affected the hydrolysis behavior of esmolol in RBC suspension.Protein binding of esmolol enantiomers in human plasma,human serum albumin(HSA) and α_1-acid glycoprotein(AGP) revealed that there was a significant difference in bound fractions between two enantiomers,especially for AGP.Our results indicated that the stereoselective protein binding might play a role in the different hydrolysis rates of esmolol enantiomers in human plasma. | Yi-Hong Tanga,b,1,Jun-Yan Wanga,1,Hai-Hong Hua,Tong-Wei Yaoa,Su Zenga,n aDepartment of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,People’s Republic of China bShanghai Institute of Technology,Shanghai 201418,People’s Republic of China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 3 |
| 2 | Value of carcinoembryonic antigen and cytokeratins for the detection of recurrent disease following curative resection of colorectal cancer显示文摘瞄准:与颜色在病人为周期性的疾病的察觉评估 carcinoembryonic 抗原(CEA ) 和 cytokeratins 的手术后的连续试金的功效在激进的外科以后的表面的腺癌。方法:在 1993 和 2000 之间,有颜色的 120 个病人表面的腺癌在外科的肠胃病学的部门经历了激进的外科, Sao Paulo-Escola Paulista de Medicina 的联邦大学, Sao Paulo,巴西。周期的手术后的评估被 assaying 标记在外部浆液,结肠镜检查和成像检查执行。CEA 的存在与 72 U/L 阀值用 LIA 地席 TPA-M Prolifigen 方法与 5 microg/L 阀值,和 cytokeratins 用 Delfia 方法被检测。结果:在第一手术后的年里,没有周期性的疾病的病人有 CEA 的正常层次( 1.5 +/- 0.9 microg/L )并且单音的同种细胞的织物多肽 antigen-M ( TPA-M , 64.4 +/- 47.8 U/L ),当有复发的病人有 CEA 的高水平时( 6.9 +/- 9.8 microg/L , P <
0.01 )并且 TPA-M ( 192.2 +/- 328.8 U/L , P <
0.05 )。在第二手术后的年期间,没有肿瘤复发的病人有 CEA 的正常层次( 2.0 +/- 1.8 microg/L )并且 TPA-M ( 50.8 +/- 38.4 U/L ),当有复发的病人有 CEA 的高水平时( 66.3 +/- 130.8 microg/L , P <
0.01 )并且 TPA-M ( 442.7 +/- 652.8 U/L , P <
0.05 )。吝啬的后续时间是 22.3 瞬间。在 23 种情况中有复发。没有完成激进的切除,五个手术被动。在肿瘤标记层次的上升先于复发的鉴定:在七的 CEA (30%) 和在十一个个人(48%) 的 TPA-M。结论:由 CEA 和 cytokeratins 的连续试金的集中的后续允许颜色的早察觉表面的瘤复发。 | Luís C Fernandes Su B Kim Sarhan S Saad Delcio Matos | 2006 | World Journal of Gastroenterology2006，12，24： | 3 |
| 3 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 4 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 5 | Small molecular nanowire arrays assisted by superhydrophobic pillar-structured sur- faces with high adhesion显示文摘 | Su B Wang S T Wu Y C | 2012 | Adv Mater2012，24，20： | 1 |
| 6 | MicroRNA-221 mediates the effects of PDGF-BB on migration, proliferation, and the epithelial-mesenehymal transition in pancreatic cancer cells 显示文摘 | Su A He S Tian B | 2013 | PLoS One2013，8，71： | 1 |
| 7 | Adaptive neural control for a class of uncertain nonlinear systems in pure-feedback form with hysteresisinput 显示文摘 | REN B B GE S S SU C Y | 2009 | IEEE Transactions on Systems Man and Cybernetics-part B2009，39，2： | 1 |
| 8 | Impact of implant design on primary stability of orthodontic mini-implants显示文摘 | Wilmes B Ottenstreuer S Su YY | | 0，，1： | 1 |
| 9 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Pricing American options: A comparison of MonteCarlo simulation approaches显示文摘 | Fu M C Laprise S B Madan D B Su Y Wu R | 2001 | Journal of Computational Finance2001，4，： | 1 |
| 11 | Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition显示文摘 | Su B Diaz-Cmz ES Landini S | 2006 | J Med Chem2006，49，4： | 1 |
| 12 | Three-Dimensional Radiation Therapy to the Primary Tumor With Concurrent Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer:Results of a Multicenter Phase 2Study From PPRA-RTOG,China显示文摘 | Su S Li T Lu B | 2015 | Int J Radiat Oncol Biol Phys2015，93，4： | 1 |
| 13 | Surface Topography of Rapidly Grown KH2PO4 Crystals with Additives:Ex Situ Investigation by Atomic Force Microscopy显示文摘 | Yang S F Su G B Tang J | 1999 | Journal of Crystal Growth1999，203，： | 1 |
| 14 | Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide显示文摘 | Wang B J Won S J Yu Z R Su C L | 2005 | Food Chem Toxicol2005，43，4： | 1 |
| 15 | Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells 显示文摘 | Su B Landini S Davis DD | 2007 | J Med Chem2007，50，7： | 1 |
| 16 | Metal-free heterogeneous ca- talysis for sustainable chemistry显示文摘 | Su D S Zhang J Frank B | 2010 | ChemSusChem2010，3，： | 1 |
| 17 | Response of soil CO2 efflux to water manipulation in a tall grass prairie ecosystem显示文摘 | Liu X Z Wan S Q Su B | | 0，，02： | 1 |
| 18 | Response of soil CO2 efflux to water ma- nipulation in a tallgrass prairie ecosystem显示文摘 | Liu X Wan S Su B | 2002 | Plant and Soil2002，240，2： | 1 |
| 19 | Fiber image analysis,Part Ill:autonomous separation of fiber cross sections显示文摘 | Xu B Wang S Su J | 1999 | Journal of Textile Institute1999，90，3： | 1 |
| 20 | Response of soil CO2 efflux to water manipulation in a tallgrass prairie ecosystem 显示文摘 | LIU X Z WAN S Q SU B | 2002 | Plant and Soil2002，240，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员