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| 1 | Comparison of the cardiacelectrophysiological effects between doxazosin and bu-nazosin显示文摘 | Lee AS Chen WP Su MJ | 2008 | J Biomed Sci2008，15，4： | 1 |
| 2 | Cytologicai differential diagnosisamong adenocarcinoma,epithelial mesothelioma,and reactivemesothelial cells in serous effusions by immunocytochemistry 显示文摘 | Su XY Li GD Liu WP | 2011 | Diagn Cytopathol2011，39，12： | 1 |
| 3 | Agmatine blocks acquisition and re -acquisition of intravenous morphine self-administration in rats显示文摘 | Su RB Wang WP Lu XQ | 2009 | Pharmacol Biochem Behav2009，92，4： | 1 |
| 4 | Sweet's syndrome: systemic signs and symptoms and associated disorders 显示文摘 | Fett DL Gibson LE Su WP | 1995 | Mayo Clin Proc1995，70，3： | 1 |
| 5 | Pyoderma gangrenosum: classification andmanagement显示文摘 | Powell FC Su WP Perry HO | 1996 | J Am Acqd Dermatol1996，34，： | 1 |
| 6 | Patent activity on water pollution and treatment in China-a scientometric perspective显示文摘 | Yue WP Yuan JP Su C | 2010 | SCIENTOMETRICS2010，83，3： | 1 |
| 7 | Constituents of the sterna of Macrocoeculus pomiferns and their in- hibitory activities against cyclooxyge-nases land-2 显示文摘 | Su BN Jones WP Cuendet M | 2004 | Phytochemistry2004，65，： | 1 |
| 8 | A Siliver (Ⅰ) Coordination Polymer Chain Containing Nanosized Tubers with Anion and Solvent Molecule Guests显示文摘 | Hong M C Zhao Y J Su WP | 2000 | Angew Chem Int Ed2000，39，： | 1 |
| 9 | Roles of sulfonylurea receptor 1 and multidrug resistance protein 1 in modulating insulin secretion in human insulinoma显示文摘BACKGROUND:Sulfonylurea receptor 1(SUR1)and multidrug resistance protein 1(MRP1)are two prominent members of multidrug resistance proteins associated with insulin secretion. The aims of this study were to investigate their expression in insulinomas and their sole and synergistic effects in modulating abnormal insulin secretion. METHODS:Fasting glucose,insulin and C-peptide were measured in 11 insulinoma patients and 11 healthy controls. Prolonged oral glucose tolerance tests were performed in 6 insulinoma patients.Insulin content,SUR1 and MRP1 were detected in 11 insulinoma patients by immunohistochemistry. SUR1 and MRP1 were also detected in 6 insulinoma patients by immunofluorescence. RESULTS:Insulinoma patients presented the typical demons-trations of Whipple's triad.Fasting glucose of each insulinoma patient was lower than 2.8 mmol/L,and simultaneous insulin and C-peptide were increased in insulinoma patients. Prolonged oral glucose tolerance tests showed that insulin secretion in insulinoma patients were also stimulated by high glucose.Immunohistochemistry and immunofluorescence staining showed that SUR1 increased,but MRP1 decreased in insulinoma compared with the adjacent islets. CONCLUSIONS:The hypersecretion of insulin in insulinomas might be,at least partially,due to the enrichment of SUR1. In contrast,MRP1,which is down-regulated in insulinomas, might reflect a negative feedback in insulin secretion. | Cheng-Jiang Li,Hua-Li Zhou,Jun Li,Hong-Tian Yao,Rong Su and Wen-Peng Li Department of Endocrinology(Li CJ,Zhou HL and Li WP),Department of Pathology,and Key Laboratory of Multi-organ Transplantation of Ministry of Public Health,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 1 |
| 10 | Rheumatic manifestations in myelodysplastic syndromes显示文摘 | Castro M Conn DL Su WP Garton JP | 1991 | J Rheumatol1991，18，5： | 1 |
| 11 | Antiphospholipid syndrome and the skin显示文摘 | Gibson GE Su WP Pittelkow MR | 1997 | J Amer Acad Derm1997，36，6： | 1 |
| 12 | The epidemiology of morphea (localized scleroderma) in Olmsted County 1960-1993 显示文摘 | Peterson LS Nelson AM Su WP | 1997 | J Rheumatol1997，24，1： | 1 |
| 13 | Clinical variants of pemphigoid 显示文摘 | Liu HN Su WP Rogers RS 3rd | 1986 | Int J Dermatol1986，25，1： | 1 |
| 14 | Competitive tension: the awareness - motivation - capability perspective 显示文摘 | Chen M -J Su KH and Tsai WP | 2007 | Academy of Management Journal2007，，1： | 1 |
| 15 | Pyodenna gangrenosum: classification and management显示文摘 | Powell FC Su WP Perry HO | 1996 | J Am Acad Dennatol1996，34，3： | 1 |
| 16 | Clinicopathologic CotTelations in leukemia culis显示文摘 | Su WP Buechner SA Li CY | 1984 | J Am Acad Dermatol1984，11，1： | 1 |
| 17 | Piceatannol, a derivative of resveratrol, moderately slows I(Na) inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts 显示文摘 | Chen WP Hung LM Hsueh CH Lai LP Su MJ | 2009 | Br J Pharmacol2009，157，3： | 1 |
| 18 | Cutaneous extramedullary hematopoiesis显示文摘 | Patel BM Su WP Perniciaro C | 1995 | J Am Acad Dermatol1995，32，51： | 1 |
| 19 | Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria显示文摘 | Su WP Davis MD Weenig RH | 2004 | Int J Dermatol2004，43，11： | 1 |
| 20 | Clinical variants of pemphigoid 显示文摘 | Liu HN Su WP Rogers RS 3rd | 1986 | Iht J Dermatol1986，25，1： | 1 |
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