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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Linkage disequilibrium between MSX1 and nonsyndromic cleft lip/palate in the Chilean population 显示文摘 | Suazo J Santos JL Carreno H | 2004 | J Dent Res2004，83，10： | 1 |
| 3 | Linkage disequilibrium between MSX1 and non -syndromic cleft lip/palate in the Chilean population 显示文摘 | Suazo J Santos JL Blanco R | 2004 | J Dent Res2004，83，10： | 1 |
| 4 | Possible association due to linkage di- sequilibrium of TGFA,RARA and BCL3 with nonsyndromic cleft lip with or without cleft palate in the Chilean population显示文摘 | Suazo J Santos JL Silva V | 2005 | Rev Med Chil2005，133，9： | 1 |
| 5 | Association between 10microsatellite markers and nonsyndromic cleft lip palate in the Chilean population显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofac J2004，41，2： | 1 |
| 6 | Citizenship under pressure : what' s a 'good soldier' to do? 显示文摘 | BOLINO M C TURNLEY W H GILSTRAP J B SUAZO M M | 2010 | Journal of Organizational Behavior2010，31，6： | 1 |
| 7 | Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population显示文摘 | Suazo J Santos JL Scapoli L | 2010 | Cleft Palate Craniofac J2010，47，5： | 1 |
| 8 | Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population 显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofac J2004，41，2： | 1 |
| 9 | Risk variants in BMP4 promoters for nonsyndromic cleft lip/palate in a Chilean population 显示文摘 | Suazo J Tapia JC Santos JL | 2011 | BMC Med Genet2011，12，： | 1 |
| 10 | No evidence lor linkage and association between 4q microsatellite markers and nonsyndromic cleft lip mid palate in chilean case- parents trios显示文摘 | Blanco R Suazo J Santos JL | 2005 | Cleft Palate Craniofac J2005，42，3： | 1 |
| 11 | No evidence for linkage and asso-ciation between 4q microsatellite markers and nonsyndromic cleft lipand palate in Chilean case-parents trios显示文摘 | Blanco R Suazo J SantosJL | 2005 | Cleft Palate Craniofac J2005，42，3： | 1 |
| 12 | Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a chilean population显示文摘 | Suazo J Santos JL Scapoli L | 2010 | Cleft Palate Craniofac J2010，47，5： | 1 |
| 13 | Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofac J2004，41，2： | 1 |
| 14 | Association between tSIb3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population显示文摘 | Suazo J Santos JL Scapoli L | 2010 | Cleft Palate Craniofac J2010，47，5： | 1 |
| 15 | Association between cleft lip/palate phenotype and non syndrome microsatellite markers located in 6p, 17q and 19q 显示文摘 | Carreno H Suazo J Paredes M | 2002 | Rev Med Chil2002，130，1： | 1 |
| 16 | Association between 10 microsatellite markers and nonsyndromic cleft lippalate in the Chilean population显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofac J2004，41，2： | 1 |
| 17 | Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population 显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofac J2004，41，2： | 1 |
| 18 | Association between bone morphogenetic protein 4 gene polymorphisms with non- syndromic cleft lip with or without cleft palate in a Chilean population显示文摘 | Suazo J Santos JL Jara L | 2010 | DNA Cell Biol2010，29，2： | 1 |
| 19 | Migration of human and mouse primordial germ cells and colonization of the developing ovary: an ultrastructural and cytochemical study 显示文摘 | Pereda J Zorn T Soto Suazo M | 2006 | Microsc Res Tech2006，69，： | 1 |
| 20 | Association be tween 10 microsatelIite markers and nonsyndromic cleft lip palate in the Chilean population显示文摘 | Blanco R Suazo J Santos JL | 2004 | Cleft Palate Craniofae J2004，41，2： | 1 |
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