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您的检索式：作者名="Subrahmanya D Vallabhapurapu"
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| 1 | Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer显示文摘Pancreatic cancer is one of the deadliest of cancers with a five-year survival of roughly 8%.Current therapies are:surgery,radiation and chemotherapy.Surgery is curative only if the cancer is caught very early,which is rare,and the latter two modalities are only marginally effective and have significant side effects.We have developed a nanosome comprised of the lysosomal protein,saposin C(SapC)and the acidic phospholipid,dioleoylphosphatidylserine(DOPS).In the acidic tumor microenvironment,this molecule,SapC-DOPS,targets the phosphatidylserine cancer-biomarker which is predominantly elevated on the surface of cancer cells.Importantly,SapC-DOPS can selectively target pancreatic tumors and metastases.Furthermore,SapC-DOPS has exhibited an impressive safety profile with only a few minor side effects in both preclinical experiments and in phase I clinical trials.With the dismal outcomes for pancreatic cancer there is an urgent need for better treatments and SapC-DOPS is a good candidate for addition to the oncologist’s toolbox. | Harold W Davis Ahmet Kaynak Subrahmanya D Vallabhapurapu Xiaoyang Qi | 2021 | World Journal of Gastrointestinal Oncology2021，13，6： | 0 |
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