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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Some Results on the Computation of Voronoi Diagrams on a Mesh with Multiple Broadcasting显示文摘 | Subrata R Zomaya A Y | 2003 | Journal of Parallel andDistributed Computing2003，63，12： | 1 |
| 3 | A Cooperative Game Framework for QoS Guided Job Allocation Schemes in Grids显示文摘 | SUBRATA R ZOMAYA A Y LANDFELDT B | 2008 | IEEE Transactions on Computers2008，57，10： | 1 |
| 4 | Cooperative power-aware scheduling in grid computing environments 显示文摘 | SUBRATA R ZOMAYA A Y LANDFELDT B | 2010 | Journal of Parallel and Distributed Computing2010，70，2： | 1 |
| 5 | Deteriorative changes of maize, groundnut and soybean seeds by fungi in storage 显示文摘 | KASHINATH B SUBRATA R | 2002 | Myeopathologia2002，155，： | 1 |
| 6 | Game theoretic approach for load balancing in computational grids显示文摘 | Subrata R Zomaya A Y Landfeldt B | 2008 | IEEE Transactions on Parallel and Distributed Systems2008，19，： | 1 |
| 7 | Single component gas transport through 10 nm pores: Experimental data and hydrodynamic prediction显示文摘 | Subrata R Cooper S M | 2005 | Journal of Membrane Science2005，253，2： | 1 |
| 8 | Market Segments and Stochastic Brand Choice Models显示文摘 | Blattberg R C Subrata S K | 1976 | Journal of Marketing Research1976，13，1： | 1 |
| 9 | Cooperative power-aware scheduling in grid computing environments显示文摘 | Subrata R Zomaya A Y Landfeldt B | | 0，，02： | 1 |
| 10 | Evolving Cellular Automata for Loca- tion Management in Mobile Computing Networks 显示文摘 | Subrata R Zomaya A Y | 2003 | IEEE Transactions on Parallel and Distributed Systems2003，14，1： | 1 |
| 11 | Cooperative game framework for QoS guided job allocation schemes in grids 显示文摘 | Subrata R Zomaya Albert Y Landfeldt B | 2008 | IEEE Transactions on Computers2008，57，10： | 1 |
| 12 | A comparison of three artificial life techniques for reporting cell planning in mobile computing显示文摘 | Subrata R Zomaya A Y | 2003 | IEEE Transactions on Parallel and Distributed Systems2003，14，2： | 1 |
| 13 | The influence of porosity and particles content on drysliding wear of cast in situ AI(Ti)-A1203(TiO2) composite 显示文摘 | ABDULHQQ A HAMID P K GHOSH P K JAIN S C SUBRATA R | 2008 | Wear2008，265，12： | 1 |
| 14 | Selective dsDNA-templated formation of copper nanoparticles in solution显示文摘 | ALEXANDRU R SUBRATA D ELMAR J | 2010 | Angewandte Chemie International Edition2010，49，： | 1 |
| 15 | A cooperative game fra- mework for QoS guided job allocation schemes in grids显示文摘 | Subrata R Zomaya A Y Landfeldt B | 2008 | IEEE Transactions on Parallel and Distributed Systems2008，，： | 1 |
| 16 | A Cooperative Game Framework for QoS Guided Job Allocation Schemes in Grids显示文摘 | Subrata R Zomaya A Y Landfeldt B | 2008 | IEEE Transactions on Parallel and Distributed Systems2008，57，10： | 1 |
| 17 | Game Theoretic Approach for Load Balancing in Computational Grids显示文摘 | Subrata R Zomaya A Y Landfeldt B | 2008 | IEEE Transactions on Parallel and Distributed Systems2008，19，1： | 1 |
| 18 | On the performance-driven load distribution for heterogeneous computational grids显示文摘 | Lu Kai Subrata R Zomaya A Y | 2007 | Journal of Computer and System Sciences2007，73，： | 1 |
| 19 | p27 and leukemia: cell cycle and be- yond 显示文摘 | Anita R Subrata B | 2015 | J Cell Physiol2015，230，3： | 1 |
| 20 | Modeling gas flow through micro-channels and nano-pores 显示文摘 | SUBRATA R RENI R HELEN C F | 2003 | Journal of Applied Physics2003，93，8： | 1 |
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