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| 1 | Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy显示文摘Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support – mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor – in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management. | Tuane Bazanella Sampaio Anne Suely Savall Maria Eduarda Ziani Gutlerrez Simone Proton | 2017 | Neural Regeneration Research2017，12，4： | 16 |
| 2 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 3 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 4 | Adult stem cells in neural repair: Current options, limitations and perspectives显示文摘Stem cells represent a promising step for the future of regenerative medicine. As they are able to differentiate into any cell type, tissue or organ, these cells are great candidates for treatments against the worst diseasesthat defy doctors and researchers around the world. Stem cells can be divided into three main groups:(1) embryonic stem cells;(2) fetal stem cells; and(3) adult stem cells. In terms of their capacity for proliferation, stem cells are also classified as totipotent, pluripotent or multipotent. Adult stem cells, also known as somatic cells, are found in various regions of the adult organism, such as bone marrow, skin, eyes, viscera and brain. They can differentiate into unipotent cells of the residing tissue, generally for the purpose of repair. These cells represent an excellent choice in regenerative medicine, every patient can be a donor of adult stem cells to provide a more customized and efficient therapy against various diseases, in other words, they allow the opportunity of autologous transplantation. But in order to start clinical trials and achieve great results, we need to understand how these cells interact with the host tissue, how they can manipulate or be manipulated by the microenvironment where they will be transplanted and for how long they can maintain their multipotent state to provide a full regeneration. | Eric Domingos Mariano Manoel Jacobsen Teixeira Suely Kazue Nagahashi Marie Guilherme Lepski | 2015 | World Journal of Stem Cells2015，7，2： | 3 |
| 5 | Clarification of passion fruit juice by microfiltration: Analyses of operating parameters, study of membrane fouling and juice quality显示文摘 | Ricardo Cardoso de Oliveira Roselene Caleffi Docê Sueli Teresa Davantel de Barros | 2012 | Journal of Food Engineering2012，，2： | 1 |
| 6 | High performance liquid chromato- graphic screening and gas chromatography-mass spectrom- etry confirmation of tebuthiuron residues in drinking wa- ter显示文摘 | Pierina Sueli Bonato | 1999 | Journal of High Resolution Chromatography1999，22，： | 1 |
| 7 | Simultaneous determination of cholesterol oxides,cholesterol and fatty acids in processed turkey meat products显示文摘 | Sueli RB Ana MRM Neura B | 2005 | Food Chemistry2005，89，： | 1 |
| 8 | Recoverable rhodium nanoparticles : synthesis, characterization and eatalytic pegormance in hydrogenation reactions 显示文摘 | Mareos J Jacinto Pedro K Kiyohara Sueli H Masunaga | 2008 | Applied Catalysis A : General2008，338，12： | 1 |
| 9 | Flow injection amperometric detection of ascorbic acid using a prussian blue film-modified electrode显示文摘 | SUELY S L C VALDIR R B PAULO J | 2001 | Talanta2001，55，： | 1 |
| 10 | Clarification of passion fruit juice by microfiltration: Analyses of operating parameters, study of membrane fouling and juice quality 显示文摘 | Ricardo C O Roselene C D Sueli T D B | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 11 | The effect of heat treatment on the cholesterol oxides,cholesterol,total lipid and fatty acid contents of processed meat products显示文摘 | Sueli RB Neura B | 2006 | Food Chemistry2006，95，： | 1 |
| 12 | Combination of hollow‐fiber liquid‐phase microextraction and capillary electrophoresis for pioglitazone and its main metabolites determination in rat liver microsomal fraction显示文摘 | Leandro Augusto Calixto Pierina Sueli Bonato | 2013 | ELECTROPHORESIS2013，，6： | 1 |
| 13 | Antimicrobial susceptibility, phage types, and pulsetypes of Salmonella typhimurium, in Sao Paulo, Brazil 显示文摘 | ANGELA C R G AANTT SUELI A F | 2006 | Mem Inst Oswaldo Cruz Rio de Janeiro2006，101，3： | 1 |
| 14 | Associations of TNF-A-1031TT and -857TT genotypes with Helicobacter pylori seropositivity and gastric atrophy among Japanese Brazilians显示文摘 | Yoshiko Atsuta Lucy S. Ito Sueli M. Oba-Shinjo Miyuki Uno Samuel Katsuyuki Shinjo Suely K.N. Marie Yasuyuki Goto Nobuyuki Hamajima | 2006 | International Journal of Clinical Oncology2006，，2： | 1 |
| 15 | Ultrasound extraction of phenolic com- pounds from coconut ( cocos nucifera) shell powder 显示文摘 | Sueli R Pinto A G | 2007 | Journal of Food Engineering2007，80，3： | 1 |
| 16 | Ultrasound as pre-treatment for drying of fruits:Dehydration of banana显示文摘 | Fabiano A N Fernandes Sueli Rodrigues | 2007 | Journal of Food Engineering2007，，82： | 1 |
| 17 | Ultrasound as pre-treatment for drying of pineapple显示文摘 | Fabiano A N Fernandes Francisco E Linhares Jr Sueli Rodrigues | 2008 | Ultrasonics Sonochemistry2008，，15： | 1 |
| 18 | Stereoselective deter- mination of hydroxychloroquine and its major metabolites in human urine by solid phase microextraction and HPLC显示文摘 | Moraes de Oliveira AR Sueli Bonato P | 2007 | J Sep Sci2007，30，15： | 1 |
| 19 | Multilocular cystic renal cell carcinoma : a report of 45 cases of a kidney tumor of low malignant potential显示文摘 | Suzigan Sueli López-Beltrán A Montironi R | 2006 | Am J Clin Pathol2006，125，2： | 1 |
| 20 | Electrochemical treatment of fresh, brine and saline produced water generated by petrochemical industry using Ti/IrO2-Ta2O5 and BDD in flow reactor显示文摘 | Suely Souza Leal Castro Elisama Vieira dos Santos Andre Jailson Cabral da Silva | 2013 | Chemical Engineering Journal2013，233，： | 1 |
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