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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 3 | 剂量-反应Meta分析报告指南(中文版)显示文摘目的制定剂量-反应Meta分析(DMA)的中文版报告指南,以提高国内系统评价人员对DMA的认识及该类论文的报告质量。方法计算机检索MEDLINE、EMbase、The Cochrane Library、CNKI和Wan Fang Data数据库,搜集中国作者发表的DMA研究,检索时限为2011年1月1日至2015年12月31日。对纳入的DMA研究,分析其发文量的变化趋势,对报告指南的使用情况,以及使用的剂量-反应Meta分析方法是否正确;基于文献分析结果初步拟定DMA报告清单,并进一步组织DMA、循证医学和临床流行病学领域专家,以及临床专家对报告清单进行讨论,根据讨论结果修改形成最终版报告指南。结果共纳入252个DMA研究,其中仅33.73%在标题明确为DMA,48.02%报告了对偏倚风险进行评价,38.49%未遵循任何报告指南,14个研究使用的方法存在错误。基于文献分析结果及现存的Meta分析报告量表初步拟定出包含47个条目的 DMA报告清单,经国内外6位专家讨论后,最终制定出包含43个条目、最能反映DMA质量的报告清单(G-Dose Checklist)。结论国内作者对报告指南的重视程度仍不够,且可能存在理解不充分的风险。应重视DMA及其他Meta分析报告指南的使用。 | 徐畅 Suhail A.R.Doi 张超 孙鑫 陈昊 周权 原瑞霞 郭鹏 张龙浩 牛玉明 邝心颖 刘同族 | 2016 | 中国循证医学杂志2016，16，10： | 5 |
| 4 | Characterization and of Ralstonia TAL-Like DNA-Binding Specificities Effectors显示文摘从 Xanthomonas sp 的抄写像使活跃之物的受动器(故事) 。为染色体工程应用被用作可定制的 DNA 有约束力的模块。Ralstonia solanacearum 像故事的蛋白质(RTL ) 展出类似的结构的特征到故事,包括一个中央 DNA 有约束力的领域填写了 of35 氨基的酸长的重复。这里,我们描绘他们作为 transcriptional 使活跃之物在植物房间原子核, mediateDNA 绑定,和力量功能本地化的 RTL 和表演。RTL 有唯一的 DNA 有约束力的体系结构并且是 enrichedin 重复变量 di 残余(RVD ) ,它决定重复 DNA 有约束力的特性。我们决定了 DNA 有约束力的 specificitiesfor RVD 序列 ND, HN, NP,和 NT。RVD ND 调停和 C 核苷酸的高度特定的相互作用, HN interactsspecifically 与 A 和 G 核苷酸,和 NP 绑在 C, A,和 G 核苷酸。而且,我们发展了一高度为设计 RTL 受动器的 efficientrepeat 集会途径。一起拿,我们的数据证明 RTL 是是要定制为指向的 genomic 和 epigenomicmodifications 绑在选择用户的 DNA 序列的优秀选择的唯一的 DNA-targetingmodules。这些调查结果将在 pathogenicityof Ralstonia spp.Key 词有关 RTL 分子的生物学和 RTL 角色便于研究: | Lixin Li Ahmed Atef Agnieszka Piatek Zahir Ali Marek Piatek Mustapha Aouida Altanbadralt Sharakuu Ali Mahjoub Guangchao Wang Suhail Khan Nina V. Fedoroff Jian-Kang Zhu Magdy M. Mahfouz | 2013 | Molecular Plant2013，6，4： | 3 |
| 5 | Acute pain management in symptomatic cholelithiasis显示文摘AIM To review the evidence for the use of different nonsteroidal anti-inflammatory drugs(NSAIDs) in the treatment of biliary colic.METHODS The strategies employed included an extensive literature review for articles and studies related to biliary colic from electronic databases including Pub Med,Science Direct,Wiley Inter Science,Medline and Cochrane from last 15 years.Keywords: 'Biliary colic','management of biliary colic','non-steroidal anti-inflammatory drugs','cholelithiasis' and 'biliary colic management'.Six randomized control trials,1 non-randomized trial and 1 meta-analysis were included in this review.The outcomes of these studies and their significance have been reviewed in this paper.RESULTS Current evidence suggests there are no set protocols for biliary colic pain management.NSAIDs are potent in the management of biliary colic,not only in terms of symptom control but in disease progression as well.Apart from the studies on diclofenac and ketorolac,there are studies which have shown that intravenous tenoxicam and injectable flurbiprofen are equally effective in managing biliary colic.The efficacy of NSAIDs is superior in terms of lower number of doses and longer duration of action in comparison to other analgesic agents.CONCLUSION This literature review has found that NSAIDs are safe and effective for pain control in biliary colic,and reduce the likelihood of further complications. | Tahir Masudi Helen Capitelli-Mc Mahon Suhail Anwar | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 2 |
| 6 | High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes显示文摘Context:The role of glycated haemoglobin(HbA1c)in the prediction of ischaemic stroke in individuals without diabetes is underestimated.Aims:We performed a study to analyse the role of HbA1c in the risk prediction of ischaemic stroke in Pakistani population without diabetes.We further studied the difference between HbA1c values of individuals with diabetes and without diabetes with stroke.Settings and design:Single centre,case–control.Materials and methods:In phase I,a total of 233 patients without diabetes with ischaemic stroke and 245 as controls were enrolled.Association of HbA1c levels,lipid profiles and blood pressure recordings with ischaemic stroke was analysed.In phase II,comparison was done between diabetics and nondiabetics with stroke.Statistical analysis:Comparison of the mean variables was performed with Student’s t-tests.Logistic regression analysis with ischaemic stroke as the dependent variable was performed for phase I.Results:In phase I,the ischaemic stroke group had significantly higher HbA1c levels(5.9±2.9%vs 5.5±1.6%)compared with controls(p<0.05).Triglyceride cholesterol,high-density lipoprotein cholesterol,systolic blood pressure,diastolic blood pressure and HbA1c were the significant determinants of stroke(p<0.05).In phase II,mean HbA1c values were significantly higher in the diabetes group(7.6±2.1 vs 6.1±2.3)(p<0.05)but other parameters were not statistically significantly different(p>0.05).Conclusions:Higher HbA1c indicated a significantly increased risk for ischaemic stroke.An HbA1c value above 5.6%(prediabetic range)predicted future risk of stroke and efforts to maintain glucose level within the normal range(≤5.6%)in individuals with high cardiovascular risk are important. | Ali Zohair Nomani Sumaira Nabi Shahzad Ahmed Mansoor Iqbal Haris Majid Rajput Suhail Rao | 2016 | Stroke & Vascular Neurology2016，1，3： | 2 |
| 7 | Short segment pedicle screw instrumentation and augmentation vertebroplasty in lumbar burst fractures: an experience显示文摘 | Suhail Afzal Saleem Akbar Shabir A. Dhar | 2008 | European Spine Journal2008，，3： | 2 |
| 8 | 选择QE或RE模型:一种带偏倚校正功能的加权方式在Meta分析中的应用显示文摘Meta分析中一个较重要的问题是偏倚,它也是导致异质性的原因。当研究存在异质性时,传统Meta分析通常使用基于倒方差法的随机效应模型对结果进行合并。尽管随机效应模型使用基于瞬时估算的量r^2表示研究真实值间偏离程度,以此获得更'保守'的合并结果。然而这种方式并未对偏倚对每项研究结果的影响进行考虑,且存在低估标准误的风险,导致合并结果同样存在偏倚。Doi等提出一种新的加权模型,QE法,能够很好地解决上述问题。本文对QE加权模型及其软件的实现进行详细介绍,并将QE加权模型法与随机效应模型结果以一示例进行对比。 | 徐畅 曾宪涛 Doi Suhail 刘同族 邝心颖 陈昊 张超 | 2016 | 中国循证医学杂志2016，16，5： | 2 |
| 9 | The Role of Matrix Metalloproteinase-7 in Redefining the Gastric Microenvironment in Response to Helicobacter pylori显示文摘 | Catherine McCaig Cedric Duval Elaine Hemers Islay Steele D. Mark Pritchard Sabine Przemeck Rod Dimaline Suhail Ahmed Keith Bodger David D. Kerrigan Timothy C. Wang Graham J. Dockray Andrea Varro | 2006 | Gastroenterology2006，，6： | 2 |
| 10 | DC reactive magnetron sputtering of titanium - structural and optical characterization of TiO2 films显示文摘 | Suhail M H Rao G M Mohan S | 1992 | J Appl Phys1992，71，： | 1 |
| 11 | Using an Adaptive Neuro-Fuzzy Inference System (AnFis) Algorithm for Automatic Diagnosis of Skin Cancer显示文摘 | Suhail M. Odeh | 2011 | 通讯和计算机(中英文版)2011，8，9： | 1 |
| 12 | The Relationship Between Government Policy and Financial Performance: A Study on the SMEs in Iraq显示文摘 | Emad Harash Karim Al-Tamimi Suhail A1-Timimi | 2014 | China-USA Business Review2014，13，4： | 1 |
| 13 | Belief in a just world and subjective well-being:Mothers of normal and Down syndrome children显示文摘 | Fatima I Suhail K | | 0，，06： | 1 |
| 14 | Fungal peritonitis caused by Lecythophora mutabilis显示文摘 | Suhail A Richard JJ Sharon H | 1985 | J Clin Microbiol1985，，22： | 1 |
| 15 | DC reactive mag- netron sputtering of titanium-structural and optical charac- terization of TiO2 films 显示文摘 | SUHAIL M H RAO G M MOHAN S | 1992 | Journal of Applied Physics1992，71，： | 1 |
| 16 | Characterization of human and mouse H19 regulatory sequences显示文摘 | Gabriel Banet Osnat Bibi Imad Matouk Suhail Ayesh Morris Laster Katherine Molner Kimber Mark Tykocinski Nathan de Groot Abraham Hochberg Patricia Ohana | 2000 | Molecular Biology Reports2000，，3： | 1 |
| 17 | Percutaneous vertebroplasty for osteoporotic fractures显示文摘 | Suhail A Shabir D Niraj B | | 0，，： | 1 |
| 18 | Future of mental health in the metaverse显示文摘The metaverse and non-fungible tokens(NFTs)were some of the hottest tech terms in 2021,according to a Google Trends search.Our review aims to describe the metaverse and NFTs in the context of their potential application in the treatment of mental health disorders.Advancements in technology have been changing human lives at an ever-increasing pace.Metaverse,also known as the threedimensional(3D)internet,is the convergence of virtual reality(VR)and physical reality in a digital space.It could potentially change the internet as we know it,with NFTs as the key building blocks in the new expansive virtual ecosystem.This immersive 3D virtual world boasts the features of the real world with the added ability to change the surrounding environment according to individual needs and requirements.VR,augmented reality(AR)and mixed reality(MR)have been employed as tools in the treatment of various mental health disorders for the past decade.Studies have reported positive results on their effectiveness in the diagnosis and treatment of mental health disorders.VR/AR/MR have been hailed as a solution to the acute shortage of mental health professionals and the lack of access to mental healthcare.But,on the flip side,young adults tend to spend a significant amount of time playing 3D immersive games and using social media,which can lead to insecurity,anxiety,depression,and behavioural addiction.Additionally,endless scrolling through social media platforms negatively affects individuals'attention span as well as aggravating the symptoms of adolescents with attention deficit hyperactivity disorder.We aimed to explore the ramifications of expanding applications of the metaverse on mental health.So far,no other review has explored the future of mental health in the context of the metaverse. | Sadia Suhail Usmani Medha Sharath Meghana Mehendale | 2022 | General Psychiatry2022，35，4： | 1 |
| 19 | Predictors of subjective wellbeing in an eastern Muslim culture 显示文摘 | SUHAIL K CHAUDHRY H R | 2004 | Journal of Social and Clinical Psychology2004，23，： | 1 |
| 20 | Development of a hierarchi- cal driver aid for parallel parking using fuzzy biomimetie approach 显示文摘 | Tarik O Mohammed M Suhail B | 2010 | Journal of Computing and Information Technology2010，18，1： | 1 |
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