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| 1 | Pancreatic fluid collections: What is the ideal imaging technique?显示文摘Pancreatic fluid collections(PFCs) are seen in up to 50% of cases of acute pancreatitis. The Revised Atlanta classification categorized these collections on the basis of duration of disease and contents, whether liquid alone or a mixture of fluid and necrotic debris. Management of these different types of collections differs because of the variable quantity of debris; while patients with pseudocysts can be drained by straight-forward stent placement, walledoff necrosis requires multi-disciplinary approach. Differentiating these collections on the basis of clinical severity alone is not reliable, so imaging is primarily performed. Contrast-enhanced computed tomography is the commonly used modality for the diagnosis and assessment of proportion of solid contents in PFCs; however with certain limitations such as use of iodinated contrast material especially in renal failure patients and radiation exposure. Magnetic resonance imaging(MRI) performs better than computed tomography(CT) in characterization of pancreatic/peripancreatic fluid collections especially for quantification of solid debris and fat necrosis(seen as fat density globules), and is an alternative in those situations where CT is contraindicated. Also magnetic resonance cholangiopancreatography is highly sensitive for detecting pancreatic duct disruption and choledocholithiasis. Endoscopic ultrasound is an evolving technique with higher reproducibility for fluid-to-debris component estimation with the added advantage of being a single stage procedure for both diagnosis(solid debris delineation) and management(drainage of collection) in the same sitting. Recently role of diffusion weighted MRI and positron emission tomography/CT with ^(18)F-FDG labeled autologous leukocytes is also emerging for detection of infection noninvasively. Comparative studies between these imaging modalities are still limited. However we look forward to a time when this gap in literature will be fulfilled. | Narendra Dhaka Jayanta Samanta Suman Kochhar Navin Kalra Sreekanth Appasani Manish Manrai Rakesh Kochhar | 2015 | World Journal of Gastroenterology2015，21，48： | 13 |
| 2 | Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis显示文摘Objective:To explore antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis(A.officinalis).Methods:In the present study the leaf extracts of A.officinalis were examined for its antibacterial potential using five different solvents against some reference strains of human pathogenic bacteria for the crude extract.Maximum activity was observed for ethyl acetate and hence different concentrations like 15μL,25μL,and 50μL of ethyl extracts was checked for its antibacterial activity.Partial purification of crude extract was carried by column chromatography and fractions were analyzed using gas chromatography-mass spectrometry(GC-MS) to identify compounds.Results:The crude ethyl acetate extracts of A.officinalis showed remarkable antibacterial activity with zones of inhibition of 13 mm against Eschericia coli(E.coli) and 11 mm against Staphylococcus aureus (S.aureus).Fraction 13(ethyl acetate:methanol= 8:2) as the most potent one against with the minimal inhibitory concentration of 30 mm against E.coli and 25 mm against S.aureus.The GCMS resultsof active column fraction(F13) revealed that the active principals were a mixture of hydroxy- 4 methoxybenzoic acid,diethyl phthalate,oleic acid.Conclusions:The leaf extracts with proven antibacterial effects can clearly be directed towards cancer treatment as to inhibiting cancer cell growth.The limited number of test organisms owes to a constraint of resource.So,the effect of strong bursts of leaf extracts on human pathogenic bacteria should further be tested on a wide range of test organisms. | Valentin Bhimba B J Meenupriya Elsa Lycias Joel D Edaya Naveena Suman kumar M Thangaraj | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 13 |
| 3 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 4 | Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer显示文摘AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early stage.METHODS:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published literature.The selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic panel.The three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA panel.RESULTS:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published literature.Eight microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and RT-qPCR.These three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although CA19-9 has higher specificity of 100%.CONCLUSION:The identified panel of three microRNA biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer. | Ganepola AP Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，1： | 9 |
| 5 | Water Cooperation Priorities in the Lancang-Mekong River Basin Based on Cooperative Events Since the Mekong River Commission Establishment显示文摘The Lancang-Mekong River has attracted much attention from researchers, but the cooperation on water issues in this river basin has been limited, even after the establishment of the Mekong River Commission(MRC). Cooperation on water resources has been determined as one of the key priority areas in the Lancang-Mekong Cooperation Mechanism, but there are no details of targets. In order to establish the priorities of water cooperation under the mechanism, we adopted nine categories to classify the objectives of 87 water cooperation events based on the ‘Lancang-Mekong Water Cooperative Events Database' from 1995 to 2015. Based on the occurrence of cooperative events, cooperative objectives, cooperative scales, and approaches to cooperation, we conducted statistical, correlation, and text analyses. Our analyses indicated the following results: under the impact of economic conditions inside and outside the river basin, full cooperation appeared more difficult than bilateral and multilateral cooperation. Each of the partners adopted different preferences for cooperation targets. Cooperation with more definite objectives was easier to establish than cooperation with broader and more complex objectives. The potential objectives for water cooperation were navigation, hydropower, joint management, data sharing, flood control and water use. Because hydropower development is controversial, and because water cooperation is avoided by most existing regional cooperation mechanisms due to its complexity, we suggest the following priority areas for water cooperation in the Lancang-Mekong River Basin. 1) Navigation and flood control/drought relief are attractive objectives for all the riparian countries across the whole watershed. 2) Data sharing should be a priority for cooperation in the watershed due to its laying the foundation for the equitable and reasonable utilization of transboundary waters. 3) Hydropower is an objective best implemented mainly through bilateral cooperation, and on tributaries. | FENG Yan WANG Wenling SUMAN Daniel YU Shiwei HE Daming | 2019 | Chinese Geographical Science2019，29，1： | 8 |
| 6 | 东莨菪亭(7-羟基-6-甲氧基香豆素)对7 ,12-二甲基苯并蒽诱导的皮肤乳头状瘤小鼠相关关键信号蛋白的影响(英文)显示文摘目的:东莨菪亭(7-羟基-6-甲氧基香豆素)是从常绿钩吻中提取的有效成分,前期体外研究证实了其抗肿瘤潜能,本研究评价其在小鼠体内的抗肿瘤作用。方法:30只健康小鼠随机分为正常对照组、模型组、溶剂对照组和低、高剂量东莨菪亭组,每组6只。正常对照组小鼠不接受任何干预,其余小鼠背部涂抹100μg 7 ,12-二甲基苯并蒽(7 ,12-di methylbenz[a]anthra-cene ,DMBA)(每周一次)和1 %巴豆油(每周2次)诱导皮肤乳头状瘤,共24周。溶剂组小鼠在造模基础上每天予2 %酒精口服,低剂量(50 mg/kg)和高剂量(100 mg/kg)东莨菪亭组小鼠每天予东莨菪亭治疗。治疗24周后,检测碱性磷酸酶、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽S-转移酶活性;信号蛋白及其受体,包括芳香烃受体(Aryl hydrocarbon receptor , AhR)、p53、细胞色素P450亚酶1A1(cytochrome P450 1A1 , CYP1A1)、增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)、信号转导和转录激活因子3(signal transducer and activator of transcription-3 ,Stat-3)、存活素、金属基质蛋白酶2、cyclin D1、c-myc、金属蛋白酶组织抑制因子2和半胱氨酸蛋白酶3(caspase-3) ,采用逆转录聚合酶链反应、蛋白印迹法或免疫沉淀法检测。结果:致癌物DMBA和巴豆油可以诱导毒性反应,生化指标中相关酶活性升高,AhR、CYP1A1、PCNA、Stat-3、存活素、MMP-2、cyclin D1和c-myc表达上调,p53、caspase-3和TI MP-2表达下调。荷瘤小鼠采用东莨菪亭治疗后,生化指标中相关酶的活性下降,蛋白表达和毒性生物标志物恢复正常。结论:东莨菪亭可能通过下调AhR表达来下调一些重要信号蛋白的表达,其作用机制可能是通过竞争性抑制存活素的表达。分裂原活化蛋白激酶可能也起到关键作用。东莨菪亭或许可作为化疗的替代药物用于治疗肿瘤。 | Soumya Sundar Bhattacharyya Saili Paul Suman Dutta Naoual Boujedaini Anisur Rahman Khuda-Bukhsh | 2010 | 中西医结合学报2010，8，7： | 7 |
| 7 | Numerical analysis of surface subsidence in asymmetric parallel highway tunnels显示文摘Tunnelling related hazards are very common in the Himalayan terrain and a number of such instances have been reported. Several twin tunnels are being planned for transportation purposes which will require good understanding for prediction of tunnel deformation and surface settlement during the engineering life of the structure. The deformational behaviour, design of sequential excavation and support of any jointed rock mass are challenging during underground construction. We have raised several commonly assumed issues while performing stability analysis of underground opening at shallow depth. For this purpose, Kainchi-mod Nerchowck twin tunnels(Himachal Pradesh, India) are taken for in-depth analysis of the stability of two asymmetric tunnels to address the influence of topography, twin tunnel dimension and geometry. The host rock encountered during excavation is composed mainly of moderately to highly jointed grey sandstone, maroon sandstone and siltstones. In contrast to equidimensional tunnels where the maximum subsidence is observed vertically above the centreline of the tunnel, the result from the present study shows shifting of the maximum subsidence away from the tunnel centreline. The maximum subsidence of 0.99 mm is observed at 4.54 m left to the escape tunnel centreline whereas the maximum subsidence of 3.14 mm is observed at 8.89 m right to the main tunnel centreline. This shifting clearly indicates the influence of undulating topography and inequidimensional noncircular tunnel. | Ratan Das P.K.Singh Ashutosh Kainthola Suman Panthee T.N.Singh | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，1： | 7 |
| 8 | Adaptive and maladaptive expression of the mRNA regulatory protein HuR显示文摘The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing and translation control the fates of thousands of mRNA transcripts and basic cellular processes. The best studied of these, HuR, is well characterized as a mediator of mRNA stability and translation, and more recently, as a factor in nuclear functions such as pre-mRNA splicing. Due to HuR's role in regulating thousands of mRNA transcripts, including those for other RNA-binding proteins, HuR can act as a master regulator of cell survival and proliferation. HuR itself is subject to multiple post-translationa modifications including regulation of its nucleocytoplasmic distribution. However, the mechanisms that govern HuR levels in the cell have only recently begun to be defined. These mechanisms are critical to cell health, as it has become clear in recent years that aberrant expression of HuR can lead alternately to decreased cell viability or to promotion of pathological proliferation and invasiveness. HuR is expressed as alternate mRNAs that vary in their untranslated regions, leading to differences in transcript stability and translatability. Multiple transcription factors and modulators of mRNA stability that regulate HuR mRNA expression have been identified. In addition, translation of HuR is regulated by numerous microRNAs, several of which have been demonstrated to have anti-tumor properties due to their suppression of HuR expression. This review summarizes the current state of knowledge of the factors that regulate HuR expression, along with the circumstances under which these factors contribute to cancer and inflammation. | Suman Govindaraju Beth S Lee | 2013 | World Journal of Biological Chemistry2013，4，4： | 7 |
| 9 | Endoscopic balloon dilation for benign gastric outlet obstruction in adults显示文摘Gastric outlet obstruction(GOO) includes obstruction in the antropyloric area or in the bulbar or post bulbar duodenal segments.Though malignancy remains the most common cause of GOO in adults,a significant number of patients have benign disease.The latter include peptic ulcer disease,caustic ingestion,post-operative anastomotic state and inflammatory causes like Crohn's disease and tuberculosis.Peptic ulcer remains the most common benign cause of GOO.Management of benign GOO revolves around confirmation of the etiology,removing the offending agent Helicobacter pylori(H.pylori),non-steroidal anti-inflammatory drugs,etc.and definitive therapy.Traditionally,surgery has been the standard mode of treatment for benign GOO.However,after the advent of through-the-scope balloon dilators,endoscopic balloon dilation(EBD) has emerged as an effective alternative to surgery in selected groups of patients.So far,this form of therapy has been shown to be effective in causticinduced GOO with short segment cicatrization and ulcer related GOO.In the latter,EBD must be combined with eradication of H.pylori.Dilation is preferably done with wire-guided balloon catheters of incremental diameter with the aim to reach the end-point of 15 mm.While it is recommended that fluoroscopic control be used for EBD,this is not used by most endoscopists.Frequency of dilation has varied from once a week to once in three weeks.Complications are uncommon with perforation occurring more often with balloons larger than 15 mm.Attempts to augment efficacy of EBD include intralesional steroids and endoscopic incision. | Rakesh Kochhar Suman Kochhar | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 10 | Air embolism complicating gastrointestinal endoscopy: A systematic review显示文摘Gastrointestinal endoscopy has become an important modality for the diagnosis and treatment of various gastrointestinal disorders. One of its major advantages is that it is minimally invasive and has an excellent safety record. Nevertheless, some complications do occur, and endoscopists are well aware and prepared to deal with the commonly recognized ones including bleeding, perforation, infection, and adverse effects from the sedative medications. Air embolism is a very rare endoscopic complication but possesses the poten-tial to be severe and fatal. It can present with cardio-pulmonary instability and neurologic symptoms. The diagnosis may be difficult because of its clinical presen-tation, which can overlap with sedation-related cardio-pulmonary problems or neurologic symptoms possibly attributed to an ischemic or hemorrhagic central nervous system event. Increased awareness is essential for prompt recognition of the air embolism, which can allow potentially life-saving therapy to be provided.Therefore, we wanted to review the risk factors, the clinical presentation, and the therapy of an air embolism from the perspective of the practicing endoscopist. | Suman Donepudi Disaya Chavalitdhamrong Liping Pu Peter V Draganov | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 6 |
| 11 | Estimation of lung cancer burden in Australia,the Philippines,and Singapore:an evaluation of disability adjusted life years显示文摘Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality. | Suman Morampudi Neha Das Arun Gowda Anand Patil | 2017 | Cancer Biology & Medicine2017，14，1： | 5 |
| 12 | 嗜曙红血球过多: 在童年的动脉的血栓和 cardioembolic 击的稀罕原因显示文摘 Eosinophilia has been reported as a very rare cause of stroke in children.The thrombotic event may be either due to cardiac damage induced by eosinophils and their granular protein,that is,the major basic protein,or the systemic hypercoagulable state induced by eosinophilia.We report here a case of eosinophilia whose initial presentation was recurrent strokes and cardiac and arterial thrombosis. | Sanjeev Kumar Sharma Suman Kumar Tulika Seth Pravas Mishra Manoranjan Mahapatra | 2012 | World Journal of Cardiology2012，4，4： | 5 |
| 13 | Microstructure,mechanical response and fractography of AZ91E/Al_(2)O_(3)_(p) nano composite fabricated by semi solid stir casting method显示文摘The present study confers to the fabrication and its characterization of magnesium alloy(AZ91E)based nano composites with nano Al_(2)O_(3) particulate reinforcements.A novel Semi Solid stir casting technique was adopted for the fabrication of the composite.An average particle size of 50 nm was used as reinforcement to disperse in matrix.The effects of change in weight fraction of reinforcements on the distribution of particles,particle–matrix interfacial reactions,physical as well as mechanical properties were reported.The SEM and EDS analysis has shown the uniform distribution of particles in the composite along with the presence of elements.The mechanical properties of reinforced and unreinforced composite were evaluated and presented.Fractography of tensile specimens was also discussed. | Sameer Kumar D Suman K.N.S Tara Sasanka C Ravindra K Palash Poddar | 2017 | Journal of Magnesium and Alloys2017，5，1： | 4 |
| 14 | A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas显示文摘 | Jeffrey R. Infante Bradley G. Somer Joon Oh Park Chung-Pin Li Max E. Scheulen Saifuddin M. Kasubhai Do-Youn Oh Yuan Liu Suman Redhu Klaudia Steplewski Ngocdiep Le | 2014 | European Journal of Cancer2014，，： | 4 |
| 15 | 高度稀释的葡萄糖溶液提高含亚砷酸盐培养基中大肠埃希氏杆菌的葡萄糖摄取(英文)显示文摘目的:高度稀释的顺势疗法药物对活体系统的作用一直被质疑。因此,本研究检测依据顺势医学理论而高度稀释的葡萄糖溶液对暴露于亚砷酸盐的大肠埃希氏杆菌的作用。方法:大肠埃希氏杆菌在Luria-Bertani培养基中培养至对数期后分组。分别加入1%或3%的葡萄糖溶液、葡萄糖30C(在70%乙醇中稀释1060倍)、1mmol/L或2mmol/L的亚砷酸钠、1mmol/L或2mmol/L的亚砷酸钠加葡萄糖30C、1mmol/L或2mmol/L的亚砷酸钠加乙醇30C(安慰剂)。分析用药后45min及90min大肠埃希氏杆菌的葡萄糖摄取、己糖激酶及葡糖激酶活性、细胞膜电位、细胞内三磷酸腺苷含量以及葡萄糖通透酶基因的表达情况,并测定细胞内及细胞外(培养基内)亚砷酸盐的浓度。结果:暴露于亚砷酸盐的大肠埃希氏杆菌的葡萄糖摄取量增加,己糖激酶及葡糖激酶活性、细胞内三磷酸腺苷含量及细胞膜电位降低,葡萄糖通透酶基因的表达增加。在加入1%或3%葡萄糖或高度稀释的葡萄糖30C的培养基内,大肠埃希氏杆菌的葡萄糖摄取量进一步增加,而在加入乙醇30C(安慰剂)的培养基内,大肠埃希氏杆菌的葡萄糖摄取量没有明显增加。结论:本研究的结果证实了高度稀释的葡萄糖溶液对于真正的葡萄糖溶液的模仿作用。这种顺势疗法理论下高度稀释的葡萄糖溶液能够调节大肠埃希氏杆菌己糖激酶和葡糖激酶的表达以及葡萄糖通透酶基因的表达,证实了顺势疗法中高度稀释的药物的有效性。 | Anisur Rahman Khuda-Bukhsh Arnab De Durba Das Suman Dutta Naoual Boujedaini | 2011 | 中西医结合学报2011，9，8： | 3 |
| 16 | Comparative study between intramedullary interlocking nailing and minimally invasive percutaneous plate osteosynthesis for distal tibia extra-articular fractures显示文摘Purpose:Treatment of distal tibia fractures poses significant challenge to orthopedic surgeon because of poor blood supply and paucity of soft tissue coverage.There is considerable controversy regarding the superior option of treatment for distal tibia fracture between the minimally invasive percutaneous plate osteosynthesis(MIPPO)technique and intramedullary interlocking(IMIL)nailing for extra-articular distal tibia fractures.The aim of our study is to compare the functional outcome between the two treatment methods.Methods:This was the prospective comparative study of 100 patients with distal third tibia fractures divided into two groups.The first group of patients were treated with MIPPO technique while the second group of patients were managed by IMIL nailing.Patients were followed up in outpatient department to assess the functional outcomes,malunion,delayed union,nonunion,superficial and deep infection between the two groups.Statistical analyses were performed using the SPSS software(version 16.0).Results:Average malunion(degrees)in the MIPPO group was 5(3—7)±1.41 vs.10.22(8—14)±2.04 in the IMIL group(p=0.001).Similarly postoperative knee pain in the IMIL group was 10%vs.2%in the MIPPO group(p=0.001).In terms of superficial infection and nonunion,the results were 8%vs.4%and 2%vs.6%for the MIPPO and IMIL group,respectively(p=0.001).Conclusion:Both procedures have shown the reliable method of fixation for distal extra-articular tibia fractures preserving the soft tissue,bony vascularity and fracture hematoma that provide a favourable biological environment for fracture healing.Considering the results of the study,we have slightly more preference for the MIPPO technique. | Kapil Mani KC Bandhu Ram Pangeni Suman Babu Marahatta Arun Sigdel Amuda KC | 2022 | Chinese Journal of Traumatology2022，25，2： | 3 |
| 17 | Control of rock joint parameters on deformation of tunnel opening显示文摘Tunneling in complex rock mass conditions is a challenging task, especially in the Himalayan terrain, where a number of unpredicted conditions are reported. Rock joint parameters such as persistence, spacing and shear strength are the factors which significantly modify the working environments in the vicinity of the openings. Therefore, a detailed tunnel stability assessment is critically important based on the field data collection on the excavated tunnel's face. In this context, intact as well as rock mass strength and deformation modulus is obtained from laboratory tests for each rock type encountered in the study area. Finite element method(FEM) is used for stability analysis purpose by parametrically varying rock joint persistence, spacing and shear strength parameters, until the condition of overbreak is reached. Another case of marginally stable condition is also obtained based on the same parameters. The results show that stability of tunnels is highly influenced by these parameters and the size of overbreak is controlled by joint persistence and spacing. Garnetiferous schist and slate characterized using high persistence show the development of large plastic zones but small block size, depending upon joint spacing; whereas low persistence, low spacing and low shear strength in marble and quartzite create rock block fall condition. | Suman Panthee P.K.Singh Ashutosh Kainthola T.N.Singh | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，4： | 3 |
| 18 | 消减食品加工过程中的真菌毒素:来自欧洲和东南亚的经验分享显示文摘在世界范围内,由真菌毒素造成的经济损失估计达数十亿美元,给人类和动物带来安全风险。粮食中真菌毒素的预防可以通过食品加工过程中进行真菌毒素的消减处理。在过去几十年里,虽然发表的科技论文中报道了大量真菌毒素防控措施,但实际生产往往需要更容易实施的、简单易行的建议和指导方针。欧洲和东南亚在真菌毒素处理到数据分析、风险评估到污染防控、差异分析到流通途径等方面可以做到相互协作,互相补充。欧洲和东南亚政府及相关行业必须在综合考虑地域、农业系统和不同国家消费者偏好的背景下,寻求平衡食品安全和地区贸易二者关系,协同管控食品供应链。以谷物为例,加工过程包括初级加工(谷物清理和碾磨操作)和二次加工(如烘焙过程中的发酵和烘烤),欧洲尤其关注烘焙食品安全性及全麦面包生产工艺对呕吐毒素的影响。结合农业、咖啡工业和科学研究人员的专业知识及亚洲咖啡生产者的具体情况,重点关注东南亚地区咖啡中赭曲霉毒素A污染问题。在农场环境中减少真菌毒素的措施给咖啡农民带来了较大的挑战,包括在规范种植农场模式下咖啡生产者和消费者之间社会经济效益和个人行为模式的相关影响因素。随着世界变得更加全球化,食品和饲料供应链也变得日趋复杂,因此,需要制定更全面的策略来确保食品供给及品质安全。 | Paula Alvito Jonathan Barcelo Johan De Meester Elias Rito Michele Suman | 2021 | 粮油食品科技2021，29，6： | 3 |
| 19 | Primary esophageal sclerosing mucoepidermoid carcinoma with “tissue eosinophilia”显示文摘Mucoepidermoid carcinoma(MEC)is a rare primary esophageal malignancy.It is characterized by poor clinical recognition,pre-operative diagnostic challenges and a lack of standardized therapeutic guidelines.We report the clinicopathological features of a hitherto unreported variant of esophageal MEC,sclerosing MEC with'tissue eosinophilia',in a mid-esophageal location in a 51-year-old female.The diagnosis of the initial biopsy was challenging,because of the small size,poor orientation and inadequate representation of the MEC components.Recognition of the resectability of the tumor prompted surgical resection and enabled a demonstration of the low grade foci containing intermediate cells,mucin pools and the hitherto undescribed presence of stromal sclerosis and tissue eosinophils in esophageal MEC.Heightened clinicopathological awareness of esophageal MEC facilitated a definitive diagnosis and patient management.Increased recognition andglobal documentation of esophageal sclerosing MEC with'tissue eosinophilia'is necessary to improve the understanding and diagnosis of this malignancy in this location and to improve management guidelines. | Suman Mewa Kinoo Kapil Maharaj Bhugwan Singh Michelle Govender Pratistadevi Kanaye Ramdial | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 20 | Case studies of coastal conflicts: comparative US/European experiences 显示文摘 | SUMAN D | 2001 | Ocean & Coastal Management2001，44，： | 2 |
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