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| 1 | Research on the Surface Subsidence Monitoring Technology Based on Fiber Bragg Grating Sensing显示文摘 | Jinyu WANG Long JIANG Zengrong SUN Binxin HU Faxiang ZHANG Guangdong SONG Tongyu LIU Junfeng QI Longping ZHANG | 2017 | Photonic Sensors2017，7，1： | 5 |
| 2 | ROS-removing nano-medicine for navigating inflammatory microenvironment to enhance anti-epileptic therapy显示文摘As a neurological disorder in the brain,epilepsy is not only associated with abnormal synchronized discharging of neurons,but also inseparable from non-neuronal elements in the altered microenvironment.Anti-epileptic drugs(AEDs)merely focusing on neuronal circuits frequently turn out deficient,which is necessitating comprehensive strategies of medications to cover over-exciting neurons,activated glial cells,oxidative stress and chronic inflammation synchronously.Therefore,we would report the design of a polymeric micelle drug delivery system that was functioned with brain targeting and cerebral microenvironment modulation.In brief,reactive oxygen species(ROS)-sensitive phenylboronic ester was conjugated with poly-ethylene glycol(PEG)to form amphiphilic copolymers.Additionally,dehydroascorbic acid(DHAA),an analogue of glucose,was applied to target glucose transporter 1(GLUT1)and facilitate micelle penetration across the blood‒brain barrier(BBB).A classic hydrophobic AED,lamotrigine(LTG),was encapsulated in the micelles via self-assembly.When administrated and transferred across the BBB,ROS-scavenging polymers were expected to integrate anti-oxidation,anti-inflammation and neuro-electric modulation into one strategy.Moreover,micelles would alter LTG distribution in vivo with improved efficacy.Overall,the combined anti-epileptic therapy might provide effective opinions on how to maximize neuroprotection during early epileptogenesis. | Zheng Zhou Keying Li Yongchao Chu Chao Li Tongyu Zhang Peixin Liu Tao Sun Chen Jiang | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 3 | DRAM:A DRL-based resource allocation scheme for MAR in MEC显示文摘Mobile Edge Computing(MEC)and 5G technology allow clients to access computing resources at the network frontier,which paves the way for applying Mobile Augmented Reality(MAR)applications.Under the MEC paradigm,MAR clients can offload complex tasks to the MEC server and enhance the human perception of the world by merging the received virtual information with the real environment.However,the resource allocation problem arises as a critical challenge in circumstances where several MAR clients compete for limited resources at the network frontier.In this paper,we aim to design an online resource allocation scheme on the MEC server that takes both high quality of experience and good fairness performance for MAR clients into consideration.We first formulate this problem as a Markov decision process and tackle the challenge of applying the deep reinforcement learning paradigm.Then,we propose DRAM,a Deep reinforcement learning-based Resource allocation scheme for mobile Augmented reality service in MEC.We also propose a self-adaptive algorithm on the MAR client that is derived based on the analysis of the MAR service to tackle client adaptation problems.The simulation results demonstrated that DRAM can provide high quality of experience and simultaneously achieve good fairness performance by coordinating with clients’adaptation algorithms. | Tongyu Song Xuebin Tan Jing Ren Wenyu Hu Sheng Wang Shizhong Xu Xiong Wang Gang Sun Hongfang Yu | 2023 | Digital Communications and Networks2023，9，3： | 0 |
| 4 | Notoginsenoside R1 Protects against Diabetic Nephropathy through TXNIP-NLRP3 Signaling Pathway显示文摘Background:Diabetic nephropathy(DN)is a microvascular complication of diabetes mellitus(DM).DN results from many factors,including changes in glomerular hemodynamics,oxidative stress and inflammation,and in-terstitial fibrosis and tubular atrophy.Panax notoginseng,a commonly used Chinese medicine,has been used in the treatment of kidney disease.Notoginsenoside R1(NGR1),the main compound isolated from P.notoginseng,has been reported to have a renoprotective role in DN.However,the therapeutic effect and mechanism of NGR1 in DN remain unclear.Objective:The present study aimed to investigate the therapeutic effect and mechanism of NGR1 in DN.Methods:In this study,mouse podocytes(MPC-5 cells)and db/db mice were used to investigate the effect of NGR1 on DN in vitro and in vivo,respectively.Blood glucose,renal function,inflammatory factors,and PI3K/AKT-Nrf2-NLRP3 signaling pathway proteins were assessed.Results:The study results indicated that NGR1 reversed cell viability induced by high glucose(HG,30 mM).The related mechanism results showed that NGR1 decreased oxidative stress by inhibiting reactive oxygen species(ROS)level and upregulating the expression of Nrf2,NQO1,and HO-1 via TXNIP targeting.In addition,NLRP3 inflammasome and PI3K/AKT were engaged in NGR1-based protection against HG-stimulated podocytes.In db/db mice,NGR1 significantly decreased blood glucose,urine protein,urine output,blood urea nitrogen,and other parameters as well as reversed kidney injury by inhibiting oxidative stress and proinflammatory response.Conclusion:Taken together,this study revealed that NGR1 exerted a significant therapeutic effect on DN both in vitro and in vivo via a mechanism related to the TXNIP-Nrf2 pathway and NLRP3 inflammasome,suggesting that NGR1 is a potential therapeutic option for DN. | Chunting Zhang Renyikun Yuan Siyuan Li Guodong Huang Kaili Sun Jiaping Pan Qiuxia Liu Xiang Gao Zhijing Wang Tongyu Li Shilong Lu Jianzhen Lv Liting Huang Hongwei Gao | 2023 | Clinical Complementary Medicine and Pharmacology2023，3，4： | 0 |
| 5 | Fragment Angular Distributions for 1000 MeV ~40(Ar)+^(209)Bi Reaction显示文摘Fragment Angular Distributions for 1000 MeV~40(Ar)+^(209)Bi Reaction￥YuXian,ChenKeliang,LiuGuoxing,ZhangJiwen,SunTongyu,WuDing... | Yu Xian, Chen Keliang, Liu Guoxing, Zhang Jiwen, Sun Tongyu,Wu Dingqing, Zhao Lili, Zang Xiang, Yin Xinmin and Qin Zhi | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 6 | Target Residues from Interaction of Uranium with 20MeV/u ^(40)Ar Ions显示文摘Target Residues from Interaction of Uranium with 20MeV/u^(40)Ar Ions￥QinZhi;LiWenxin;SunTongyu;ZhaoLin;ZhangXiang;YinXinming;?.. | Qin Zhi Li Wenxin Sun Tongyu Zhao Lin Zhang Xiang Yin Xinming Wu Dingqing Zheng Jiwen Liu Guoxin Jin Genming and Zhao Zhizheng | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 7 | Isotopic Distributions of Hafnium from Interaction of Heavy Ions with ^(nat)W显示文摘Isotopic Distributions of Hafnium from Interaction of Heavy ions with ^(nat)W￥ZhangXiang;LiWenxin;SunTongyu;YinXinmin;QinZhi;... | Zhang Xiang Li Wenxin Sun Tongyu Yin Xinmin Qin Zhi Zhao Lili Wu Dingqing S. Ambe Y. Ohkuba Y. Kobayashi M. Iwamoto H. Maeda and F. Ambe(Institute of Physics and Chethecal Research, Japan.) | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 8 | Real Deadtime in a γSpectrometer显示文摘Real Deadtime in a γ Spectrometer￥ZhaoZhizhengandSunTongyuInthemethodwhichwasusedtoobtaintheproducedcrosssectionofisotopesnuc... | Zhao Zhizheng and Sun Tongyu | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 9 | Automated Penetration Testing with Fine-Grained Control through Deep Reinforcement Learning显示文摘Penetration testing(PT)is an active method of evaluating the security of a network by simulating various types of cyber attacks in order to identify and exploit vulnerabilities.Traditional PT involves a time-consuming and labor-intensive process that is prone to errors and cannot be easily formulated.Researchers have been investigating the potential of deep reinforcement learning(DRL)to develop automated PT(APT)tools.However,using DRL in APT is challenged by partial observability of the environment and the intractability problem of the huge action space.This paper introduces RLAPT,a novel DRL approach that directly overcomes these challenges and enables intelligent automation of the PT process with precise control.The proposed method exhibits superior efficiency,stability,and scalability in finding the optimal attacking policy on the simulated experiment scenario. | Xiaotong Guo Jing Ren Jiangong Zheng Jianxin Liao Chao Sun Hongxi Zhu Tongyu Song Sheng Wang Wei Wang | 2023 | Journal of Communications and Information Networks2023，8，3： | 0 |
| 10 | Mass Yield Distribution in Intermediate Energy Heavy Ion Reactions | Zhang, Xiang Li, Wenxin Yin, Xinmin Wen, Wanxin Sun, Tongyu Jin, Genming Luo, Qingzheng | 1995 | Chinese journal of nuclear physics1995，，3： | 0 |
| 11 | Role of chemokines in the hepatocellular carcinoma microenvironment and their translational value in immunotherapy显示文摘The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven tumor.Chronic inflammation allows nascent tumors to escape immunosurveillance.Chemokines are small,soluble,secreted proteins that can regulate the activation and trafficking of immune cells during inflammation.Several studies have shown that various chemokines with overarching functions disrupt the immune microenvironment during the initiation and progression of HCC.The dysregulated chemokine network in HCC contributes to multiple malignant processes,including angiogenesis,tumor proliferation,migration,invasion,tumor low response,and resistance to immune therapy.Here,we summarize the current studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,highlighting potential translational therapeutic uses for modulating the chemokine system in HCC. | Yijun Wang Mengyu Sun Tongyue Zhang Yangyang Feng Xiangyuan Luo Meng Xie Xiaoyu Ji Danfei Liu Wenjie Huang Limin Xia | 2022 | Oncology and Translational Medicine2022，8，1： | 0 |
| 12 | CsPbBr_(3)-DMSO merged perovskite micro-bricks for efficient X-ray detection显示文摘Inorganic perovskite wafers with good stability and adjustable sizes are promising in X-ray detection but the high synthetic temperature is a hindrance.Herein,dimethyl sulfoxide(DMSO)is used to prepare the CsPbBr_(3)micro-bricks powder at room temperature.The CsPbBr_(3)powder has a cubic shape with few crystal defects,small charge trap density,and high crystallinity.A trace amount of DMSO attaches to the surface of the CsPbBr_(3)micro-bricks via Pb-O bonding,forming the CsPbBr_(3)-DMSO adduct.During hot isostatic processing,the released DMSO vapor merges the CsPbBr_(3)micro-bricks,producing a compact and dense CsPbBr_(3)wafer with minimized grain boundaries and excellent charge transport properties.The CsPbBr_(3)wafer shows a large mobility-lifetime(μτ)product of 5.16×10^(-4)cm^(2)·V^(-1),high sensitivity of 14,430μC·Gyair^(-1)·cm^(-2),low detection limit of 564 nGyair·s^(-1),as well as robust stability in X-ray detection.The results reveal a novel strategy with immense practical potential pertaining to high-contrast X-ray detection. | Tongyu Shi Wenjun Liu Jiongtao Zhu Xiongsheng Fan Zhengyu Zhang Xingchen He Rui He Jiahong Wang Kezhen Chen Yongshuai Ge Xiangming Sun Yanliang Liu Paul K.Chu Xue-Feng Yu | 2023 | Nano Research2023，16，7： | 0 |
| 13 | Beware of the serious harm of veterinary drug poisoning:a case report显示文摘Veterinary drugs are substances(including pharmaceutical feed additives)used to prevent,treat,and diagnose diseases or regulate the physiological functions of animals.Veterinary drug poisoning in humans is relatively rare both in China and the rest of the world.Here,we report a case of death from veterinary drug poisoning from avermectin-closantel.Avermectin-closantel is a broad-spectrum antiparasitic drug,which has high efficacy against a variety of trematodes and nematodes. | Ping Dai Jin Sun Tongyue Zhang Zhiqiang Zhou Zixi Wen Tianzi Jian Aerbusili Genjiafu Baotian Kan Xiangdong Jian | 2024 | World Journal of Emergency Medicine2024，15，2： | 0 |
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