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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Dynamic alterations of cerebral pial mieroeireulation during experimental subarachnoid hemorrhage 显示文摘 | Sun BL Zheng CB Yang MF | 2009 | Cell Mol Neurobio12009，29，2： | 1 |
| 3 | L-arginine improves cerebral blood perfusion and vasomotion of microvessels following suharachnoid hemorrhage in rats显示文摘 | Sun BL Zhang SM Xia ZL | 2003 | Clin Hemorheol Microcirc2003，29，： | 1 |
| 4 | Adoptive regulatory T-eeU therapy protects against cerebral isehemia 显示文摘 | Li P Gan Y Sun BL | 2013 | Ann Neurol2013，74，3： | 1 |
| 5 | Effects of Ginkgo biloba extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after subarachnoid hemorrhage显示文摘 | Sun BL Xia ZL Yang MF | 2000 | Clin Hemorheol Mieroeire2000，23，234： | 1 |
| 6 | Adoptive regulatory T-ceU therapy protects against cerebral ischemia 显示文摘 | Li P Gan Y Sun BL | 2013 | Ann Neurol2013，74，3： | 1 |
| 7 | Effects of ginkgo biloha extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after suharachnoid hemorrhage 显示文摘 | Sun BL Xia ZL Yan MF Qiu PM | 2000 | Clin Hemorheol Microcirc2000，23，4： | 1 |
| 8 | Dynamic alterations of cerebral pial microcirculation during experimental subarachnoid hemorrhage显示文摘 | Sun BL Zheng CB Yang MF | 2009 | Cell Mol Neurobiol2009，29，2： | 1 |
| 9 | Effects of blockade of cerebral lymphatic drainage on regional cerebral Mood flow and brain ede-ma after subaraehnoid hemorrhage显示文摘 | Xia ZL Wang JR | 2006 | Clin Hemorheol Micro-circ2006，34，12： | 1 |
| 10 | The surgical treatment of isolated left-sided hepatolithiasis:a 22-year experience显示文摘 | Sun WB Han BL Cai JX | 2000 | Surgery2000，127，5： | 1 |
| 11 | Over-expression of the insulin-like growth factor l receptor in human colon carcinomas 显示文摘 | Matthias MW Fottner C Sun BL | 2002 | Cancer2002，95，： | 1 |
| 12 | Changes of nitric oxide, oxide free radicals, and systolic arterial blood pressure in rats with experimental lymphatostatic encephalopathy 显示文摘 | Xia ZL Sun BL Zheng YH | 2006 | Clin Hemorheol Microcirc2006，34，12： | 1 |
| 13 | Decreased proliferation of mes- enchymal stem cells in corticosteroid-induced osteonecrosis of femoral head显示文摘 | Wang BL Sun W Shi ZC et ai | 2008 | Orthopedics2008，31，5： | 1 |
| 14 | L-arginine improves cerebral blood perfusion and vasomotion of microvessels following subarachnoid hemorrhage in rats显示文摘 | Sun BL Zhang SM Xia ZL | 2003 | Clin Hemorheol Microcirc2003，29，34： | 1 |
| 15 | Electricity generation at high ionic strength in microbial fuel cell by a newly isolated Shewanella marisflavi EP1 显示文摘 | Huang JX Sun BL Zhang XB | 2010 | Appl Microbiol Biot2010，85，4： | 1 |
| 16 | The surgical treatment of isolated left-sided hepatolithiasis:a 22-year experience显示文摘 | Sun WB Han BL Cai JX | 2000 | Surgery2000，127，5： | 1 |
| 17 | The surgical treatment of isolatedleft-sided hepatolithiasis: a 22-year experience显示文摘 | SUN WB HAN BL CAI JX | 2000 | Surgery2000，127，5： | 1 |
| 18 | Treatment of nontraumatic osteonecresis of the femoral head using bone impaction grafting through a femoral neck window显示文摘 | Wang BL Sun W Shi ZC | | 0，，05： | 1 |
| 19 | Electricity generation at high ionic strength in microbial fuel cell by a newly isolated Shewanella marisflavi EPI显示文摘 | Huang JX Sun BL Zhang XB | 2010 | Appl Microbiol Biotechnol2010，85，4： | 1 |
| 20 | The surgical treatment of leftsided hepatolithiasis:a 22-year expericence 显示文摘 | Sun WB Han BL Cai JX | 2000 | Surgery2000，127，5： | 1 |
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