2篇
您的检索式：作者名="Sun Hanzhang"
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| 1 | Parthenolide reveals an allosteric mode to inhibit the delSGylation activity of SARS-CoV-2 papain-like protease显示文摘The coronavirus papain-like protease(PLpro)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for viral polypeptide cleavage and the deISGylation of interferon-stimulated gene 15(ISG15),which enable it to participate in virus replication and host innate immune pathways.Therefore,PLpro is considered an attractive antiviral drug target.Here,we show that parthenolide,a germacrane sesquiterpene lactone,has SARS-CoV-2 PLpro inhibitory activity.Parthenolide covalently binds to Cys-191 or Cys-194 of the PLpro protein,but not the Cys-111 at the PLpro catalytic site.Mutation of Cys-191 or Cys-194 reduces the activity of PLpro.Molecular docking studies show that parthenolide may also form hydrogen bonds with Lys-192,Thr-193,and Gln-231.Furthermore,parthenolide inhibits the deISGylation but not the deubiquitinating activity of PLpro in vitro.These results reveal that parthenolide inhibits PLpro activity by allosteric regulation. | Zhihui Zou Huizhuang Shan Demeng Sun Li Xia Yulong Shi Jiahui Wan Aiwu Zhou Yunzhao Wu Hanzhang Xu Hu Lei Zhijian Xu Yingli Wu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
| 2 | Chemistry of marine resources-XIX. The molecule design and synthesis of crow-link type Alkyd resin and its enrichment behaviour For potassium ion in sea water显示文摘Chemistryofmarineresources-XIX.Themoleculedesignandsynthesisofcrow-linktypealkydresinanditsenrichmentbehaviourforpotassiumion... | Sun Yushan Feng Fei Sun Hanzhang Peng Qiqiang Xia Zongfeng and Wang Wei(Department of Marine Chemistry, Ocean University of Qingdao, Qingdao 266003, China) | 1994 | Acta Oceanologica Sinica1994，13，3： | 0 |
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