| 1 | A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir显示文摘oseltamivir 的使用,广泛地是的 stockpiled 为在可能的鸟的流行性感冒的使用的药之一流行,被报导了与 neuropsychiatricdisorders 和严重皮肤反应被联系,首先在日本。这里,我们在 dbSNP 数据库识别了非同义的 SNP (单个核苷酸多型性) , R41Q 在 humancytosolic sialidase 的酶的活跃地点附近,是 oseltamivir 的目标的病毒 neuraminidase 的一个相当或相同事物。在欧洲、非洲的美国人口的 9.29% 亚洲人口和没有的这 SNPoccurred。Ourstructural 分析和 Ki 大小使用试管内 sialidase 试金显示这 SNPcould 增加人的 sialidase 的非计划中的有约束力的亲密关系到 oseltamivir 羧化物, oseltamivir 的活跃形式,因此减少 sialidase 活动。另外,这 SNP 自己与一项内在地更低的 sialidase 活动导致酶,由它的增加的 Km 证明 Vmax 珍视并且减少。理论上,到有这 SNP 的人的 oseltamivir 的管理可能进一步减少他们的 sialidase 活动。我们注意 oseltamivir 的 reportedneuropsychiatric 副酌和人的 sialidase-relateddisorders 的已知的症状的类似。我们建议这个充实亚洲人的 sialidase 变化由 SNP 引起了,在同型结合的形式可能,可以与对 oseltamivir 的某些严重不利反应被联系。 | Chuan-Yun Li Quan Yu Zhi-Qiang Ye Ying Sun Quanyuan He Xiao-Mo Li Wuxue Zhang Jingchu Luo Xiaocheng Gu Xiaofeng Zheng Liping Wei | 2007 | Cell Research2007，17，4： | 5 |
| 3 | Effect of Flotation Reagents on the Cake Moisture of Copper Concentrate显示文摘The effect of reagents used in separating chalcopyrite from pyrite on the cake moisture of the copper concentrate at Daye Iron Mine Mineral Processing Plant was investigated. The results showed that the dosage of lime used for depressing pyrite was the main factor that increased the filter cake moisture of copper concentrate. With increasing the dosage of lime, the cake moisture of copper concentrate increased sharply. The cause was concluded to be the addition of lime to the pulp, which resulted in the formation of floc and a high pH value. The collector Z-200#, used for collecting chalcopyrite, had, as well, an adverse effect on the cake moisture of copper concentrate, but its effect was inferior in respect to that of lime. The cake moisture of copper concentrate can be decreased by changing the method with which lime is added and the pH value of pulp is regulated. The experiment results showed that the sulfuric acid was the best regulator. When the clarified liquor of lime was used as a depressant and the pH value of the pulp was regulated to 6.5€*7.0 by adding sulfuric acid, the cake moisture of copper concentrate was reduced from 15.49% to 13.13%. The examination of chalcopyrite surface by using ESCA (Electron Spectroscopy for Chemical Analysis) showed that calcium sulfate and iron hydroxide had formed on the surface of chalcopyrite when lime was added to the pulp. The formation of calcium sulfate and iron hydroxide on its surface increased the hydrophilicity of chalcopyrite so that its cake moisture increased. The addition of sulfuric acid to the pulp not only removed the calcium sulfate, but also reduced the concentration of iron hydroxide on the surface of chalcopyrite so that the cake moisture of copper concentrate was decreased. | Tichang Sun, Quanyuan Song, Chengfan Hu, Aiguo Yu ( Resources Engineering School, University of Science and Technology Beijing, Beijing 100083, China Daye Iron Mine, Tieshan District, Huangshi, Hubei 435006, China) | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员