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| 1 | Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice显示文摘瞄准:增加的证据建议那 probucol,有抗氧化剂活动的一个类脂化合物阴沉的代理人,可能为有经由在胆固醇和 neuroinflammation 的减小的 hyperlipidemia 的 ischemic 击的治疗有用。在这研究,我们检验了 probucol 是否能在正常和 hyperlipidemic mice.Methods 经由 anti-neuroinflammatory 行动免于大脑 ischemic 损害:主要老鼠 microglia 和鼠科的 BV2 microglia 不为 3 h,和版本暴露于 lipopolysaccharide (LPS ) , PGE2, IL-1β并且在 NF-κ 的 IL-6,以及变化; B,表明小径的 MAPK 和 AP-1 被估计。ApoE 击倒老鼠被喂包含 0.004% 的一本高脂肪的食谱, 0.02% , 0.1%(wt/wt ) 为 10 个星期的 probucol 而正常 C57BL/6J 老鼠收到了 probucol (3, 10, 30 mg· kg -1·d-1, po ) 为 4 d。然后,所有老鼠通过中间的服的动脉吸藏(MCAO ) 受到焦点的服的局部缺血。神经病学的赤字被获得在外科以后的 24 h,然后大脑为测量服的梗塞尺寸和支持 inflammatory mediators.Results 的生产被移开:在对待 LPS 的 BV2 房间和主要 microglial 房间,有 probucol 的预告的处理(1, 5, 10 μ mol/L ) dose-dependently 禁止了版本没有, PGE2, IL-1β并且 IL-6,它发生在抄写铺平。而且, probucol 的禁止的行动与 NF-κ 的 downregulation 被联系;表明小径的 B, MAPK 和 AP-1。在有 MCAO 的正常鼠标, probucol 的管理前 dose-dependently 减少了梗塞卷和改进神经病学的功能。这些效果被支持 inflammatory 调停人的减少的生产伴随(iNOS, COX-2, IL-1, IL-6 ) 。在 ApoE 击倒,老鼠喂了一本高脂肪的食谱, 0.1% probucol 的管理前显著地减少了梗塞体积,改进了跟随 MCAO 的神经病学的赤字,并且减少全部胆固醇并且 LDL 胆固醇 levels.Conclusion:Probucol 禁止导致 LPS 的 microglia 激活并且改善在经由它的 anti-neuroinflammatory 行动的正常和 hyperlipidemic 老鼠的服的 ischemic 损害,建议那 probucol 为 ischemic 击和 hyperlipidemia 为病人的治疗有潜力与或在风险。 | Yeon Suk JUNG Jung Hwa PARK Hyunha KIM So Young KIM Ji Young HWANG Ki Whan HONG Sun Sik BAE Byung Tae CHOI Sae-Won LEE Hwa Kyoung SHIN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 16 |
| 2 | Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression显示文摘Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages.To investigate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments,adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation.Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation.We also detected the expression levels of neurogenic cell markers(doublecortin)and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor.Radiation-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.Sodium butyrate pretreatment reversed these changes.These findings suggest that sodium butyrate can improve radiation-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression.The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences(approval No.KIRAMS16-0002)on December 30,2016. | Hae June Lee Yeonghoon Son Minyoung Lee Changjong Moon Sung Ho Kim In Sik Shin Miyoung Yang Sangwoo Bae Joong Sun Kim | 2019 | Neural Regeneration Research2019，14，9： | 7 |
| 3 | Mechanism of Action of the Antimicrobial Peptide Buforin II: Buforin II Kills Microorganisms by Penetrating the Cell Membrane and Inhibiting Cellular Functions显示文摘 | Chan Bae Park Hun Sik Kim Sun Chang Kim | 1998 | Biochemical and Biophysical Research Communications1998，，1： | 2 |
| 4 | Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice显示文摘 | Sun Haeng Park Ji Hyun Kim Se Jin Park Sun Sik Bae Young Whan Choi Jin Woo Hong Byung Tae Choi Hwa Kyoung Shin | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 5 | Akt3 knockdown induces mitochondria dysfunction in human cancer cells显示文摘 | Minjee Kim Young Yeon Kim Hye Jin Jee Sun Sik Bae Na Young Jeong Jee-Hyun Um Jeanho Yun | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 1 |
| 6 | Mechanism of Action of the Antimicrobial Peptide Buforin II: Buforin II Kills Microorganisms by Penetrating the Cell Membrane and Inhibiting Cellular Functions显示文摘 | Chan Bae Park Hun Sik Kim Sun Chang Kim | 1998 | Biochemical and Biophysical Research Communications1998，，1： | 1 |
| 7 | Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity显示文摘 | Ju Sun Kim Jin Cheul Kim Sang Hee Shim Eun Ju Lee Wen Yi Jin Kihwan Bae Kun Ho Son Hyun Pyo Kim Sam Sik Kang Hyeun Wook Chang | 2006 | Archives of Pharmacal Research2006，，： | 1 |
| 8 | Graduated injection needles and snares for polypectomy are useful for measuring colorectal polyp size显示文摘 | Yil Sik Hyun Dong Soo Han Joong Ho Bae Hye Sun Park Chang Soo Eun | 2011 | Digestive and Liver Disease2011，，5： | 1 |
| 9 | The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms显示文摘 | Ji Hyun Kim Sun Haeng Park Young Whan Kim Jung Min Ha Sun Sik Bae Guem San Lee Su In Cho Byung Tae Choi Hwa Kyoung Shin | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 10 | Improving the mechanical properties of extruded Mg–3Al–1Zn alloy by cold pre-forging显示文摘 | Sung Hyuk Park Ha Sik Kim Jun Ho Bae Chang Dong Yim Bong Sun You | 2013 | Scripta Materialia2013，，3： | 1 |
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