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| 1 | Hepatitis B virus genotypes:Global distribution and clinical importance显示文摘At least 600000 individuals worldwide annually die of hepatitis B virus(HBV)-related diseases,such as chronic hepatitis B(CHB),liver cirrhosis(LC),and hepatocellular carcinoma(HCC).Many viral factors,such as viral load,genotype,and specific viral mutations,are known to affect disease progression.HBV reverse transcriptase does not have a proofreading function,therefore,many HBV genotypes,sub-genotypes,mutants,and recombinants emerge.Differences between genotypes in response to antiviral treatment have been determined.To date,10 HBV genotypes,scattered across different geographical regions,have been identified.For example,genotype A has a tendency for chronicity,whereas viral mutations are frequently encountered in genotype C.Both chronicity and mutation frequency are common in genotype D.LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes.Pathogenic differences between HBV genotypes explain disease intensity,progression to LC,and HCC.In conclusion,genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. | Mustafa Sunbul | 2014 | World Journal of Gastroenterology2014，20，18： | 42 |
| 2 | Distribution of hepatitis B virus genotypes in patients with chronic hepatitis B in Turkey显示文摘AIM: Hepatitis B virus (HBV) strains isolated worldwide has been classified into eight genomic groups deduced from genome comparisons and designated as genotypes A to H. We aimed to investigate prevalence of HBV genotypes and subtypes in Turkey.METHODS: A total of 88 chronic hepatitis B (CHB) patients from 15 hospitals throughout the country were included.Patients who were HBsAg positive in serum at least for 6 mo, who had HBV-DNA in serum and elevation of ALT levels more than two times upper limit of normal, and who had percutaneous liver biopsy within 6 mo were included. Genotyping of HBV was done by restriction fragment length polymorphism (RFLP). The patients received subcutaneous 9 MU interferon-α 2a thrice a week for a period of 6 mo.RESULTS: Genotype D was detected in 78 of 88 (88.7%)patients, however, genotyping failed in two patients (2.3%),while no product was obtained in eight (9.0%) patients.Regarding subtypes, D2 was more prevalent (67 patients between 78% and 85.9%) followed by subtype D2+deletion (seven patients of 78 or 8.9%), subtype D1 (three patients of 78% or 3.9%) and subtype D3 (one patient of 78% or 1.3%). Thirty-three patients (37.5%) were HBeAg positive compared to 55 (62.5%) anti-HBe positive patients. The endpoint for the viral response of HBeAg positive patients was 27.2%, while it was found 52.7% in HBeAg negative patients (P<0.05). Long-term persistent viral response was 29.5% for all patients.CONCLUSION: This multi-center study indicates that the predominant genotype with CHB patients in Turkey like in other Mediterranean countries is genotype D. | Mustafa Sunbul Hakan Leblebicioglu | 2005 | World Journal of Gastroenterology2005，11，13： | 3 |
| 3 | Specific mutations of basal core promoter are associated with chronic liver disease in hepatitis B virus subgenotype D1 prevalent in Turkey显示文摘 | Mustafa Sunbul Masaya Sugiyama Fuat Kurbanov Hakan Leblebicioglu Anis Khan Abeer Elkady Yasuhito Tanaka Masashi Mizokami | 2013 | Microbiol Immunol2013，，2： | 2 |
| 4 | Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non- dipper hypertension显示文摘 | Sunbul M Gerin F Durmus E | 2014 | Clin Exp Hypertens2014，36，4： | 1 |
| 5 | Ureterosopic treatment of ureteral lithiasis with pneumatic lithotripsy analysis of 287 procedures in a public hospital显示文摘 | CEYLAN K SUNBUL O SAHIN A | 2005 | Uml Res2005，33，6： | 1 |
| 6 | Response to hepatitis B vaccine in HBsAg/anti-HBs negative and anti HBc positive subjects显示文摘 | Sunbul M Leblebicioglu H Esen S | 2000 | Scand J Infect Dis2000，32，3： | 1 |
| 7 | l)ynamic copper(Ⅰ) imaging in mammalian cells with a genetically encoded fluorescent copper (Ⅰ) sensor 显示文摘 | Wegner S V Arslan H Sunbul M | 2010 | J Am Chem Soc2010，132，8： | 1 |
| 8 | Tissue types as prognostic risk factor in hepatitis B virus infection显示文摘 | Akcam Z Sunbul M Durupinar B | 2002 | Indian J Gastroenterol2002，21，4： | 1 |
| 9 | Thwaites' diagnostic scoring and the prediction of tuberculous meningitis 显示文摘 | Sunbul M Atilla A Esen S | 2005 | Med Princ Pract2005，14，3： | 1 |
| 10 | Response to hepati-tis Bvaccine in HBsAg/anti-HBs negative and anti-HBc posi- tive subjeels显示文摘 | Sunbul M Leblebicioglu H Esen S | 2000 | Scand J Infect Dis2000，32，3： | 1 |
| 11 | Nonalcoholic steatohepatitis score is an independent predictor of right ventricular dysfunction in patients with nonalcoholic fatty liver disease显示文摘 | Sunbul M Kivrak T Durmus E | 2015 | Cardiovasc Ther2015，33，5： | 1 |
| 12 | Neutrophil to lym- phocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension显示文摘 | Sunbul M Gerin F Durmus E | 2014 | Clin Exp Hy- pertens2014，36，4： | 1 |
| 13 | Neutrophil to lym-phocyte and platelet to lymphocyte ratio in patients withdipper versus non-dipper hypertension显示文摘 | Sunbul M Gerin F Durmus E | 2014 | Clin Exp Hy-pertens2014，36，4： | 1 |
| 14 | ureteospic treatment of ureterllithasis with pnematic lithotyipsy: analysis of 287 procedures in a public hospital显示文摘 | CEYLAN K SUNBUL O SAHIN A | 2005 | Urol Res2005，33，6： | 1 |
| 15 | Thwaites' diagnostic scoring and the prediction of tuberculous meningitis显示文摘 | Sunbul M Atilla A Esen S | 2005 | Med Princ Pract2005，14，3： | 1 |
| 16 | Right ventricular and atri- al functions in systemic sclerosis patients without pulmonary hy- pertension: speckle-tracking echocardiographic study 显示文摘 | Durmus E Sunbul M Tigen K | 2014 | Herz2014，19，： | 1 |
| 17 | Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension 显示文摘 | Sunbul M Gerin F Durmus E | 2014 | Clin Exp Hypertens2014，36，4： | 1 |
| 18 | Arterial stiff- ness in patients with non-alcoholic fatty liver disease is related to fibrosis stage and epicardial adipose tissue thickness显示文摘 | SUNBUL M AGIRBASLI M DURMUS E | 2014 | Atherosclerosis2014，237，2： | 1 |
| 19 | Arterial stiff- ness in patients with non-alcoholic fatty liver disease is related to fibrosis stage and epicardial adipose tissue thickness显示文摘 | SUNBUL M AGIRBASLI M DURMUS E | 2014 | Atherosclerosis2014，237，2： | 1 |
| 20 | Evolutionary development of business process centered architectures using component technologies 显示文摘 | Sunbul Asuman Weber Herbert Padberg Julia | 2001 | Journal of Integrated Design & Process Science2001，5，3： | 1 |
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