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| 1 | Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa显示文摘Objective:To identify the hepatoprotective and in vitro antioxidant activity of Lumnitzera racemosa(L.racemosa)leaf extract.Methods:Animals in Group 1 served as vehicle control,Group 2 served as liepatoloxin(CCL_4 treated)group,Group 3 served as positive control(Silyinarin)group,and Group 4,5 and 6 served as(75,150 and 300 mg/kg bw p.o.)L.raremosa leaf extract treated groups.Moreover,in vitro antioxidant DPPH,hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO)and super oxide dismutase(SOD)were also analyzed for the leaf extract.Results:The levels of the serum parameters such as serum glutamic oxaloacetic transaminase(SCOT),serum glutamic pyruvic transaminase(SGPT),alkaline phosphatase(ALP),bilirubin,cholesterol(CHL),sugar and lactate dehydrogenase(LDU)were significantly increased in CCL_4 treated rats when compared with the control group(P<0.05).But the L.racemosa leaf extract treated rats showed maximum reduction of SGOT[(210.36±19.63)IU/L],SGPT[(82.37±13.87)IU/L],ALP[(197.63±23.43)IU/L],bilurubin[(2.15±0.84)mg/dL],cholesterol[(163.83±15.63)mg/dL],sugar[(93.00±7.65)mg/dL]and LDH[(1134.00±285.00)IU/L]were observed with the high dose(300 mg/kg bw)of leaf extract treated rats.Histopathological scores showed that,no visible changes were observed with high dose(300 mg/kg bw)of leaf extract treated rats except few mild necrosis.The IC_(50)values were observed as(56.37±4.87)μg/mL,(57.68±1.98)μg/mL,(64.I5±2.90)μg/mL,(61.94±3.98)μg/mL,(94.53±1.68)μg/mL and(69.7±2.65)μg/mL for DPPH,HRSA,NO,FRAP,LPO and SOD radical scavenging activities,respectively.Conclusions:In conclusion,the hepatoprotective effect of the L.racemosa leaf extract might be due to the presence of phenolic groups,terpenoids and alkaloids and in vitro antioxidant properties. | Sundaram Ravikumar Murugesan Gnanadesigan | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 21 |
| 2 | Hepatoprotective and antioxidant properties of marine halophyte Luminetzera racemosa bark extract in CCL_4 induced hepatotoxicity显示文摘Objective:To identify the hepatoprotective and antioxidant activity of Luminetzera racemosa (L racemosa)bark extract.Methods:Wistar albino rats were divided into 6 groups:Group 1 served as control;Group 2 served as hepatotoxin(CCL4 treated) group;Group 3 served as positive control(Silymarin) treated groups;Group 4,5 and 6 served as(100,200 and 300 mg/kg bw p.o.) L racemosa bark extract treated groups.Moreover,in vitro antioxidant indexes,including DPPH, hydroxyl radical scavenging activity(HRSA),NO,ferric reducing antioxidant power(FRAP),lipid hydroperoxide(LPO) and super oxide dismutase(SOD) were also analyzed in the bark extract. Results:The results suggested that,the level of serum glutamate oxyloacetic transaminase(SCOT), serum glutamic pyruvic transaminase(SGPT),alkaline phosphatise(ALP),bilurubin,cholesterol, sugar and lactate dehydrogenase(LDH) were significantly(P<0.05) increased in hepatotoxin treated rats when compared with the control group.But,the maximum reduction of SGOT[(225.36±13.65) IU/L],SGPT[(96.85±17.36) IU/L],ALP[(315.37±17.16) IU/L],bilirubin[(2.97±0.46) mg/dL], cholesterol[(163.73±17.54) mg/dL],sugar[(127.35±27.35) mg/dL]and LDH[(1 784.00±268.36) IU/L] were observed with 300 mg/kg bw of bark extract treated rats.Histopathological scores showed that,no visible changes were observed with high dose(300 mg/kg bw) of bark extract treated rats except mild fatty changes.The in vitro antioxidant assays showed that,the IC50 values were observed as(44.17±6.87)μ/mL,(42.45±2.81)μg/mL,(62.37±3.98)μg/mL,(54.24±3.09)μg/mL, (87.25±5.90)μg/mL and(71.54±5.42)μg/mL for DPPH.HRSA,NO,FRAP,LPO and SOD radical scavenging activities,respectively.Conclusions:The hepatoprotective and antioxidant activities of the bark extract might be to the presence of unique chemical classes such as flavonoids, alkaloids and polyphenols. | Murugesan Gnanadesigan Sundaram Ravikumar Samuel Jacob Inbaneson | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 4 |
| 3 | In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum显示文摘Objective:To identify the possible antiplasmodial compounds from leaf,stem,root and flower extracts of Ocimum canum(O.canum),Ocimum sanctum(O.sanctum) and Ocimum basilicum (O.basilicum).Methods:The O.canum,O.sanctum and O.basilicum were collected from Ramanalhapuram District,Tamil Nadu and the extraction was carried out in ethanol.The filter sterilized extracts(100,30,23,12.5,6.23 and 3.125μg/mL) of leaf,stem,root and flower extracts of O.canum,O.sanctum and O.basilicum were tested for antiplasmodial activity against Plasmodium falciparum(P.falciparum).The potential extracts were also tested for their phytochemical constituents.Results:The leaf extract of O.sanctum showed excellent antiplasmodial activity(IC50 3538μg/mL) followed by leaf extract of O.basilicum(IC50 4341μg/mL). The leaf extract of O.canum,root extracts of O.sanctum and O.basilicum,the stem and flower extracts of all the three tested Ocimum species showed IC50 values between 50 and 100μg/mL Statistical analysis reveals that,significant antiplasmodial activity(P<0.01) was observed between the concentrations and time of exposure.The chemical injury to erythrocytes was also carried out and it shows that,there were no morphological changes in erythrocytes by the ethanolic extract of O.canum,O.sanctum and O.basilicum.The in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,flavonoids,phenols,saponins,triterpenoids,proteins,resins, steroids and tannins in the ethanolic extracts of tested plants.Conclusions:The ethanolic leaf extracts of O.sanctum possess lead compounds for the development of antiplasmodial drugs. | Samuel Jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 4 | In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum显示文摘Objective:To identify the possible anliplasmodial compounds from Achyranlhes aspera(A. aspera).Acalypha indica(A.indica),Jatropha glandulifera(J.glanduUfera)and Phyllanlhus amarus(P.amarus).Methods:The A.aspera,A.indica,J.glandulifera and P.ainarus were collected along Palk Strait and the extraction was carried out in ethanol.The filter sterilized extracts(100,50,25,12.5,6.25 and 3.125μg/mL) of leaf,stem,root and flower extracts of A aspera,A. indica,J.glandulifera and P.amarus were tested for anliplasmodial activity against Plasnuxlium falciparum.The potential extracts were also tested for their phytochemical constituents.Results: Of the selected plants species parts,the stem extract of A.indica showed excellent antiplasmodial activity(IC_(50)=43.81μg/mL) followed by stem extract of J.glandulifera(IC_(50)= 49.14μg/mL).The stem extract of A.aspera,leaf and root extracts of A.indka,leaf,root and seed extracts of J. glanduUfera and leaf and stem extracts of P.amarus showed IC_(50),values between 50 and 100 μg/ mL.Statistical analysis revealed that,significant antiplasmodial activity(P<0.0l) was observed between the concentrations and time of exposure.The chemical injury to erythrocytes was also carried out and it showed that there were no morphological changes in erythrocytes by the elhanolic extract of all the tested plant extracts.The in vitro antiplasmodial activity might be due to the presence of alkaloids,glycosides,flavonoids.phenols,saponins,triterpenoids,proteins, and lannins in the elhanolic extracts of tested plants.Conclusions:The elhanolic stem extracts of P.amarus and J.glandulifera possess lead compounds for the development of antiplasmodial drugs. | Samuel Jacob Inbaneson Sundaram Ravikumar Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 5 | In vitro antiplasmodial activity of Spiro benzofuran compound from mangrove plant of Southern India显示文摘Objective:To find out the in vitro antipalsmodial activities of mangrove leaf extracts.Methods: In vitro antiplasmodial assay was carried out with 13 different mangrove plants.Column chromatography was performed with the most potent Agecerious corniculatum(A.corniculatum) by using various solvent extractions.GC-MS was also preformed with the most potent ethanolic fraction of the A.corniculatum extract.Results:Of the 13 mangroves plants, A.corniculatum showed maximum percentage of parasitemia suppression(94.98±1.16)%.Column chromatography was performed with A.corniculatum with different solvents and the methanolic extract showed maximum percentage(99.73±1.63)%of parasitemia inhibition at 150μg/mL concentration with the IC50 value of(29.28±3.23)μg/mL concentration.The results of the GC-MS analysis observed that,the most potent methanolic extract showed maximum retention time(30.687 RT) and the chemical class was identified as Spiro[benzofuran-2(3 H),1’-(3 cyclohexane)-2’,3- dione,7-chloro-4’,6]which was responsible for the antiplasmodial activity.Conclusions:It is concluded from the present study that,the chemical constituents of A.corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future. | Sundaram Ravikumar Ganesan Ramanathan Murugesan Gnanadesigan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 2 |
| 6 | In vitro antibacterial activity of the metal oxide nanoparticles against urinary tract infectious bacterial pathogens显示文摘 | Sundaram Ravikumar Ramasamy Gokulakrishnan Pandi Boomi | 2012 | Asian Pacific Journal of Tropical Disease2012，，2： | 2 |
| 7 | In vitro antiplasmodial activity of ethanolic extracts of South Indian medicinal plants against Plasmodium falciparum显示文摘 | Sundaram Ravikumar Samuel Jacob Inbaneson Palavesam Suganthi | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 1 |
| 8 | Study on antibacterial activity of chemically synthesized PANI-Ag-Au nanocomposite显示文摘 | Pandi Boomi Halliah Gurumallesh Prabu Paramasivam Manisankar Sundaram Ravikumar | 2014 | Applied Surface Science2014，，： | 1 |
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