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| 1 | Recent progress in the structural study of ion channels as insecticide targets显示文摘Ion channels,many expressed in insect neural and muscular systems,have drawn huge attention as primary targets of insecticides.With the recent technical breakthroughs in structural biology,especially in cryo-electron microscopy(cryo-EM),many new high-resolution structures of ion channel targets,apo or in complex with insecticides,have been solved,shedding light on the molecular mechanism of action of the insecticides and resistance mutations.These structures also provide accurate templates for structure-based insecticide screening and rational design.This review summarizes the recent progress in the structural studies of 5 ion channel families:the ryanodine receptor(RyR),the nicotinic acetylcholine receptor(nAChR),the voltage-gated sodium channel(VGSC),the transient receptor potential(TRP)channel,and the ligand-gated chloride channel(LGCC).We address the selectivity of the channel-targeting insecticides by examining the conservation of key coordinating residues revealed by the structures.The possible resistance mechanisms are proposed based on the locations of the identified resistance mutations on the 3D structures of the target channels and their impacts on the binding of insecticides.Finally,we discuss how to develop“green”insecticides with a novel mode of action based on these high-resolution structures to overcome the resistance. | Hadiatullah Hadiatullah Yongliang Zhang Arthur Samurkas Yunxuan Xie Rajamanikandan Sundarraj Han Zuilhof Jianjun Qiao Zhiguang Yuchi | 2022 | Insect Science2022，29，6： | 2 |
| 2 | Comparison of chemokine and receptor gene expression between Wharton’s jelly and bone marrow-derived mesenchymal stromal cells显示文摘 | Sudha Balasubramanian Parvathy Venugopal Swathi Sundarraj Zubaidah Zakaria Anish Sen Majumdar Malancha Ta | 2012 | Cytotherapy2012，，1： | 1 |
| 3 | Alpha-smooth muscle aetin expression enhances cell traction force显示文摘 | Chen J Li H Sundarraj N | | 0，，04： | 1 |
| 4 | Regional heterogeneity in human corneal and limbal epithelia: an immunohistoehemical evaluation 显示文摘 | Wiley L SundarRaj N Sun I'F | 1991 | Invest Ophthalmol Vis Sci1991，32，3： | 1 |
| 5 | Screening of higher plants and animal faeces for the fungitoxioity against Rhizoctonia solani显示文摘 | Sundarraj T Kurucheve V Jayaraj J | 1996 | Indian Phytopathology1996，49，4： | 1 |
| 6 | 显示文摘 | Voller V R | 1993 | Int J Heat Mass Transfer1993，36，3： | 1 |
| 7 | A multi-period optimization model for the procurement of component-based enterprise information technologies显示文摘 | Sundarraj R P Talluri S | 2003 | European Journal of Operational Research2003，146，2： | 1 |
| 8 | Evaluating componentized enterprise information technologies: A multi attribute modelingapproach 显示文摘 | JOSEPH S SUNDARRAJ R P | 2003 | Information Systems Frontiers2003，5，3： | 1 |
| 9 | Curtailing over expression of E2F3 in breast cancer using siRNA (E2F3) based gene silencing显示文摘 | Vimala K Sundarraj S Sujitha MV | 2012 | Arch Med Res2012，43，6： | 1 |
| 10 | A multi-period optimization model for the procurement of component-based enterise information technologies 显示文摘 | R P Sundarraj Srinivas Tallttfi | 2003 | European Journal of Operational Research2003，，146： | 1 |
| 11 | Differentiation in cultured limbal epithelium as defined by keratin expression显示文摘 | Sundarraj N Thoft RA | 1991 | Invest Ophthalmol Vis Sci1991，32，： | 1 |
| 12 | Modelling of microsegregation显示文摘 | Voller V R Sundarraj S | 1993 | Material Science and Technology1993，9，6： | 1 |
| 13 | A Web-based AHP Approach to Standardize the Process of Managing Service-contracts 显示文摘 | Sundarraj R | 2004 | Decision- Support Systems2004，37，7： | 1 |
| 14 | The stochastic modeling of solidification structures in alloy 718 remelt ingots 显示文摘 | Nastac L Sundarraj S Yu KO | 1998 | JOM (USA)1998，，： | 1 |
| 15 | 显示文摘 | | 1993 | Materials Science and Technology1993，，9： | 1 |
| 16 | Factors for strategic evaluation of enterprise information technologies显示文摘 | Sarkis J Sundarraj R P | | 0，，： | 1 |
| 17 | The stochastic modeling of solidification structures in alloy 718 remelt ingots显示文摘 | Laurentiu Nastac Suresh Sundarraj Kuang-O Yu Yuan Pang | 1998 | JOM1998，，3： | 1 |
| 18 | The muhipotential cells of the limbus显示文摘 | Thofl RA Wiley LA Sundarraj N | 1989 | Eye1989，3，2： | 1 |
| 19 | Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-blinding epidermal growth factor-like growth factor signaling 显示文摘 | Block ER Matela AR SundarRaj N Iszkula ER Klarlund JK | 2004 | J Biol Chem2004，279，24： | 1 |
| 20 | A web-based AHP approach to standardize the process of managing service-contracts显示文摘 | Sundarraj R | 2004 | Decision Support Systems2004，37，7： | 1 |
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