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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Cardiovascu- lar effects of intravenous induction in children:comparison be- tween propofol and thiopentone显示文摘 | Aun C S T Sung R Y T O'Meara M E | 1993 | Br J Anaesth1993，70，： | 1 |
| 3 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 4 | Ada Boost with SVM-based component classifiers显示文摘 | Li Xuchun Wang Lei Sung E | 2008 | Engineering Applications of Artificial Intelligence2008，21，5： | 1 |
| 5 | Infiltration analysis to evaluate the surficial stability of two-layered slopes considering rainfall characteristics 显示文摘 | SUNG E C | 2009 | Engineering Geology2009，105，1： | 1 |
| 6 | Defense system in the biliaey tract against bacterial infection显示文摘 | Sung J Y Costerton J W Shaffer E A | 1992 | Dig Dis Sci1992，37，： | 1 |
| 7 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
| 8 | Active learning for solving the incomplete data problem in facial age classification by the furthest nearest neighbor criterion 显示文摘 | Wang J G Sung E Wel Y | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 9 | Haemorrhagic -fever -like changes and normal chest radiograph in a doctor with SARS显示文摘 | Wu E B Sung J J | 2003 | Lancet2003，361，9368： | 1 |
| 10 | Hydrophobic bile salt inhibits bacterial adhesion on billary stent material显示文摘 | Sung J Y Shaffer E A Lani K | 1994 | Dig Dis Sic1994，39，10： | 1 |
| 11 | Failure modes of silicon powder negative electrode in lithium secondary battery显示文摘 | Ryu J H Kim J W Sung Y E | 2004 | Electrochem Solid-State Lett2004，7，10： | 1 |
| 12 | Failure modes of silicon powder negative electrode in lithium secondary batteries显示文摘 | RYU J H KIM J W SUNG Y E | 2004 | Electrochem Solid-State Lett2004，7，10： | 1 |
| 13 | Diamond Growth on Array of Seeds :the Revolution of Diamond Production 显示文摘 | Sung J C Sung M Sung E | 2006 | Th/n So//d F//rna2006，498，： | 1 |
| 14 | The origin of enhanced L1 chemical ordering in Ag-doped FePt nanoparticles 显示文摘 | Sung Y M Lee M K Kim K E | 2007 | Chem Phys Lett2007，443，： | 1 |
| 15 | Luteolin exerts anti - tumor activity through the suppression of epidermal growth factor receptor - mediated pathway in MDA - MB -231 ER - negative breast cancer cells 显示文摘 | Lee E J Oh S Y Sung M K | 2012 | Food and Chemical Toxicology2012，50，11： | 1 |
| 16 | Differentiated governance of foreign subsidiaries in transnational corporations: An agency theory perspective显示文摘 | Bongjin Kim John E Prescott and Sung Min Kirn | 2005 | Journal of International Management2005，11，1： | 1 |
| 17 | Smooth muscle tumors of the ovary: A clinicopathologic study of 54 cases em- phasizing prognostic criteria, histologic variants, and dif- ferential diagnosis 显示文摘 | Lerwill MF Sung R Oliva E | 2004 | Am J Surg Pathol2004，28，11： | 1 |
| 18 | Weight gain within the normal weight range predicts ultrasonographically detected fatty liver in healthy Korean men显示文摘 | Chang Y Ryu S Sung E | | 0，，10： | 1 |
| 19 | Safety and tolera- bility of high-dose intravenous esomeprazole for preven- tion of peptic ulcer rebleeding显示文摘 | Kuipers E J Sung J J Barkun A | 2011 | Adv Ther2011，28，2： | 1 |
| 20 | The Experiences of TurnoverIntention in Early Stage Nurses显示文摘 | Lee S Y Oh E J Sung K M | 2013 | J East-West Nurs Res2013，19，2： | 1 |
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