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您的检索式：作者名="Susan Heavey"
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| 1 | PIM kinase inhibition:co-targeted therapeutic approaches in prostate cancer显示文摘PIM kinases have been shown to play a role in prostate cancer development and progression,as well as in some of the hallmarks of cancer,especially proliferation and apoptosis.Their upregulation in prostate cancer has been correlated with decreased patient overall survival and therapy resistance.Initial efforts to inhibit PIM with monotherapies have been hampered by compensatory upregulation of other pathways and drug toxicity,and as such,it has been suggested that co-targeting PIM with other treatment approaches may permit lower doses and be a more viable option in the clinic.Here,we present the rationale and basis for cotargeting PIM with inhibitors of PI3K/mTOR/AKT,JAK/STAT,MYC,stemness,and RNA Polymerase I transcription,along with other therapies,including androgen deprivation,radiotherapy,chemotherapy,and immunotherapy.Such combined approaches could potentially be used as neoadjuvant therapies,limiting the development of resistance to treatments or sensitizing cells to other therapeutics.To determine which drugs should be combined with PIM inhibitors for each patient,it will be key to develop companion diagnostics that predict response to each co-targeted option,hopefully providing a personalized medicine pathway for subsets of prostate cancer patients in the future. | Sabina Luszczak Christopher Kumar Vignesh Krishna Sathyadevan Benjamin S.Simpson Kathy A.Gately Hayley C.Whitaker Susan Heavey | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 2 | Health Info Too Complex for Many in U.S.显示文摘药品标签、认可表格和其他健康信息中经常包括太多行话术语,大多数美国人都难以理解--这个问题可能会导致健康更差,花费更高的局面。专家小组周四如是说。 | Susan Heavey 李静 | 2004 | 当代外语研究2004，，5： | 0 |
| 3 | Marriage Does Not Change Outlook on Life显示文摘选注者言:我是2003年元旦结婚的,今年28岁。我从读大学起,就订阅《科技英语学习》,一直至今。在《科技英语学习》上,我曾经读到以下关于婚姻的文字:For a married couple to expect perfection in each other is unrealistic. The sooner we accept that as a fact of life, the better we will be able to adjust to each other and enjoy togetherness. 'Happily incompatible' is a good adjustment. | Susan Heavey 方雨妹 | 2003 | 当代外语研究2003，，4： | 0 |
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