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| 1 | 水稻质核互作雄性不育系的微效恢复基因定位和排除方法研究显示文摘以232个协青早A/B456///协青早A/B456∥B456植株组成的分离群体为材料,调查花粉可育率和自交结实率,并采用121个在染色体上分布比较均匀的SSR多态性标记进行QTL检测。发现22个SSR标记分别与10个花粉育性位点连锁,分布于第2,5,6,8,10,12染色体上;28个标记分别与16个小穗育性位点连锁,分布于第1,2,4,5,6,8,10和11染色体上;13个标记同时与花粉育性和小穗育性连锁,小穗育性与花粉育性QTL差异是花粉可育度和自交结实率不平行性的遗传基础。各可育位点对花粉育性和小穗育性的提高效应比较小,为微效基因,但每个花粉育性位点的存在都可导致不育系败育不彻底。协青早A中发现1个花粉可育位点Pf5-1,与分子标记Bm55和Rm13紧密连锁,进行分子标记辅助选择,可能排除协青早A的微效恢复基因(可育位点),达到完全不育。协青早A存在8个小穗育性位点,能够提高自交结实率,有助于杂种F1结实率的提高,有利于提高不育系的可恢复性。多数微效恢复基因显示为部分隐性或隐性,是水稻质核互作雄性不育系选育难的重要原因。采用不育系/拟用亲本∥保持系/拟用亲本的方式,观察杂种育性分离,可对拟用亲本的微效恢复基因有所了解,用保持系/部分保持系∥保持系的方式可提高微效恢复基因排除的效率。 | 李新奇 Xu Yun-bi Xiao Jin-hua 袁隆平 Susan Mc Couch | 2010 | 杂交水稻2010，，2： | 3 |
| 2 | Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo显示文摘 | Susan Mc Donnell Vivek Chaudhry Jorge Mansilla-Soto Zhao-Shi Zeng Wei-ping Shu Jose G. Guillem | 1999 | Clinical and Experimental Metastasis1999，，4： | 1 |
| 3 | Zoledronic Acid显示文摘 | Susan MC Stuart N | 2001 | Drugs2001，61，6： | 1 |
| 4 | Apelin, the ligand for the endothelial G-protein coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo显示文摘 | Christopher MC Susan LD Melanie KM | 2006 | Developmental Biology2006，296，1： | 1 |
| 5 | Hope in advanced cancer patients显示文摘 | Susan E Mc Clement Harvey Max Chochinov | 2008 | European Journal of Cancer2008，44，： | 1 |
| 6 | Implementing geriatric models of care= A role of the gerontological clinical nurse specialist- part I显示文摘 | Deborah MC Tamara LB Susan S | 2012 | Geriatric Nursing2012，33，3： | 1 |
| 7 | Disruption of the endometrial-myometrial border during pregnancy as a risk factor for adenomyosis 显示文摘 | Kathryn MC Susan DH Polly AM | 2002 | Am J Obstet Gynecol2002，187，： | 1 |
| 8 | Developing Re- search Competence to Support Evidence - Based Practice 显示文摘 | Lore EB Elizabeth AS Susan MS Susan MC | 2005 | Journal of Professional Nursing2005，21，6： | 1 |
| 9 | Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer显示文摘 | Susan Mc Carthy Andrea Caporali Steve Enkemann | 2007 | Mol Oncol2007，1，2： | 1 |
| 10 | Predicting cyanobacteria dominance in lakes 显示文摘 | Downing John A Watson Susan B Cauley Edward Mc | 2001 | Canadian Journal of Fisheries and Aquatic Sciences2001，58，： | 1 |
| 11 | Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo显示文摘 | Christopher MC Susan LD Melanie KM | 2006 | Developmental Biology2006，296，1： | 1 |
| 12 | Not just a grain of rice:the quest for quality显示文摘 | Fitzgerald Melissa A Mc Couch Susan R Hall Robert D | 2009 | Trends in Plant Science2009，14，3： | 1 |
| 13 | Group I1 metabotropic glutamate receptor activetion attenuates peripheral sensitization in inflammatory states显示文摘 | JUNHUI D SHENGTAI Z SUSAN MC | 2008 | Neuroscienee2008，154，2： | 1 |
| 14 | Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors显示文摘 | Elyad MD Susan MC | 1998 | Brain Research1998，785，： | 1 |
| 15 | Predicting cyanobacteria dominance in lakes 显示文摘 | Watson Susan B Cauley Edward Mc | 2001 | Canadian Journal of Fisheries and Aquatic Sciences2001，58，： | 1 |
| 16 | One year experience with computer-assisted propofol sedation for colonoscopy显示文摘AIM To report our one-year experience with computer assisted propofol sedation(CAPS) for colonoscopy as the first United States Medical Center to adopt CAPS technology for routine clinical use.METHODS Between September 2014 and August 2015, 2677 patients underwent elective outpatient colonoscopy with CAPS at our center. All colonoscopies were performed by 1 of 17 gastroenterologists certified in the use of the CAPS system, with the assistance of a specially trained nurse. Procedural success rates, polyp detection rates, procedure times and recovery times were recorded and compared against corresponding historical measuresfrom 2286 colonoscopies done with midazolam and fentanyl from September 2013 to August 2014. Adverse events in the CAPS group were recorded.RESULTS The mean age of the CAPS cohort was 59.9 years(48.7% male); 31.3% were ASA?Ⅰ, 67.3% ASA Ⅱ and 1.4% ASA Ⅲ. 45.1% of the colonoscopies were for screening, 31.5% for surveillance, and 23.4% for symptoms. The mean propofol dose administered was 250.7 mg(range 16-1470 mg), with a mean fentanyl dose of 34.1 mcg(0-100 mcg). The colonoscopy completion and polyp detection rates were similar to that of historical measures. Recovery times were markedly shorter(31 min vs 45.6 min, P < 0.001). In CAPS patients, there were 20(0.7%) cases of mild desaturation(< 90%) treated with a chin lift and reduction or temporary discontinuation of the propofol infusion, 21(0.8%) cases of asymptomatic hypotension(< 90 systolic blood pressure) treated with a reduction in the propofol rate, 4(0.1%) cases of marked agitation or discomfort due to undersedation, and 2 cases of pronounced transient desaturation requiring brief(< 1 min) mask ventilation. There were no sedation-related serious adverse events such as emergent intubation, unanticipated hospitalization or permanent injury. CONCLUSION CAPS appears to be a safe, effective and efficient means of providing moderate sedation for colonoscopy in relatively healthy patients. Recovery times were much shorter than historical measures. There were few adverse events, and no serious adverse events, related to CAPS. | Otto S Lin Danielle La Selva Richard A Kozarek Deborah Tombs Wade Weigel Ryan Beecher Johannes Koch Susan Mc Cormick Michael Chiorean Fred Drennan Michael Gluck Nanda Venu Michael Larsen Andrew Ross | 2017 | World Journal of Gastroenterology2017，23，16： | 0 |
| 17 | Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort显示文摘AIM: To investigate the potential burden of nonalcoholic steatohepatitis(NASH) and advanced fibrosis in a hispanic community.METHODS: Four hundred and forty two participants with available ultrasonography data from the Cameron County Hispanic Cohort were included in this study. Each participant completed a comprehensive questionnaire regarding basic demographic information, medical history, medication use, and social and family history including alcohol use. Values of the nonalcoholic fatty liver disease fibrosis score(NFS), FIB4 index, BARD score, and Aspartate aminotransferase to Platelet Ratio Index(APRI) were computed using the blood samples collected within 6 mo of liver ultrasonography from each participant. Hepatic steatosis was determined by ultrasonography. As part of univariable analysis, for continuous variables, comparisons among groups were performed with student-t test, one way analysis of variance, and Mann-Whitney test. Pearson χ2 and the Fisher exact test are used to assess differences in categorical variables. For multivariable analyses, logistic regression analyses were performed to identify characteristics associated with hepatic steatosis. All reported P values are based two-sided tests, and a P value of less than 0.05 was considered to indicate statistical significance.RESULTS: The mean age and body mass index(BMI) of the study participants were 49.1 years and 31.3 kg/m2, respectively. Among them, 65.6% were females, 52% had hepatic steatosis, 49.5% had metabolic syndrome, and 29% had elevated aminotransferases. Based on established cut-offs for diagnostic panels, between 17%-63% of the entire cohort was predicted to have NASH with indeterminate or advanced fibrosis. Participants with hepatic steatosis had significantly higher BMI(32.9 ± 5.6 kg/m2 vs 29.6 ± 6.1 kg/m2, P < 0.001) and higher prevalence rates of elevation of ALT(42.2% vs 14.6%, P < 0.001), elevation of aspartate aminotransferase(38.7% vs 18.9%, P < 0.001), and metabolic syndrome(64.8% vs 33%, P < 0.001) than those without hepatic steatosis. The NFS scores(P = 0.002) and the APRI scores(P = 0.002) were significantly higher in those with steatosis but the scores of the FIB4 index and BARD were similar between the two groups. After adjusting for age, gender and BMI, elevated transaminases, metabolic syndrome and its components, intermediate NFS and APRI scores were associated hepatic steatosis in multivariable analysis. CONCLUSION: The burden of NASH and advanced fibrosis in the Hispanic community in South Texas may be more substantial than predicted from referral clinic studies. | Jen-Jung Pan Susan P Fisher-Hoch Chaoru Chen Ariel E Feldstein Joseph B Mc Cormick Mohammad H Rahbar Laura Beretta Michael B Fallon | 2015 | World Journal of Hepatology2015，7，11： | 0 |
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