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| 1 | Negative biomarker-based male fertility evaluation: sperm phenotypes associated with molecular-level anomalies显示文摘基于 Biomarker 的精子分析提高人的不孕的处理并且改善在家畜的繁殖性能。否定基于 biomarker 的途径集中于蛋白质和对有缺点的精子唯一的 ligands,不管他们的词法显型,把自己借给由流动 cytometry (FC ) 的分析。一个主要例子是 spermatid 特定的 thioredoxin SPTRX3/TXNDC8,在原子液泡和有缺点的人的精子的过剩细胞质保留了。不肥沃结合高精液 SPTRX3 当低 SPTRX3 与多重艺术出生被联系了时,多半是更少由帮助繁殖治疗(艺术) 和对周期性的流产敏感的更多怀孕。Ubiquitin,一个小、支持解朊作用的共有原子价 posttranslational 蛋白质修饰词在有缺点的 posttesticular 精子并且在损坏蛋白质总数的表面上被发现, spermiogenic 的 aggresomes 起源。精液 ubiquitin 内容与富饶和常规精液参数,并且与 lectins LCA 有约束力的精子否定地相关(透镜 culinaris 凝集素;揭示改变的精子表面) 并且 PNA (Arachis hypogaea/peanut 凝集素;揭示 acrosomal 畸形性或损坏) 。Postacrosomal 鞘第一次世界大战域有约束力的蛋白质(PAWP ) ,在授精期间在卵母细胞激活含有,从有缺点的人和动物精子宫外或不在。因而,有在不肥沃的夫妇的艺术结果并且与在公牛的富饶的 PAWP 相互关联的 FC 参数。试金基于上述 biomarkers 被合为屏蔽协议的复合 FC 精液,并且 lectins 和 ubiquitin 的表面表示被利用了开发纯化方法由地验证了的基于 nanoparticle 的公牛精液人工的授精试用。这些进展与 FC 技术和 genomics/proteomics-based biomarker 发现的革新变手牵手。 | Peter Sutovsky Mahmoud Aarabi Antonio Miranda-Vizuete Richard Oko | 2015 | Asian Journal of Andrology2015，17，4： | 2 |
| 2 | Mitochondrial DNA content of mature spermatozoa and oocytes in the genetic model Drosophila 显示文摘 | Wolff JN Sutovsky P Ballard JW | 2013 | Cell Tissue Res2013，353，1： | 1 |
| 3 | Relationship between brain natriuretic peptide, myocardial wall stress and ventrieular arrhythmia severity显示文摘 | SUTOVSKY I KATOH T OHNO T | 2004 | Jpn Heart J2004，45，5： | 1 |
| 4 | Increased disruption of sperm plasma membrane at sperm immobilization promotes dissociation of perinuclear theca from sperm chromatin after intracytoplasmic sperm injection in pigs显示文摘 | Katayama M Sutovsky P Yang B S | 2005 | Reproduction2005，130，： | 1 |
| 5 | Paternal contributions to the mammalian zygote:fertilization after sperm-egg fusion显示文摘 | Sutovsky P Schatten G | 2000 | Int Rev Cytol2000，195，： | 1 |
| 6 | Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance显示文摘 | Sutovsky P | 2004 | Reprod Bio Mcd Online2004，8，1： | 1 |
| 7 | Ultrastructural aspects of mammalian fertilization: new discoveries and inspirations from the work of Daniel Szollosi显示文摘 | Sutovsky P Schatten G | 1998 | Reprod Nutr Dev1998，38，： | 1 |
| 8 | Centrosome reduction during gametogenesis and its significance显示文摘 | Manandhar G Schatten H Sutovsky P | 2005 | Biol Reprod2005，72，： | 1 |
| 9 | Differential expression of genes encoding constitutive and inducible 20S proteasomal core subunits in the testis and epididymis of theophylline-or 1,3-dinitrobenzene~exposed rats显示文摘 | TENGOWSKI M W FENG D SUTOVSKY M | 2007 | Biol Reprod2007，76，1： | 1 |
| 10 | Depletion of Glutathione during Bovine Oocyte Maturation Reversibly Blocks the Deeondensation of the Male Pronuclear and Prenuclear Apposition during 显示文摘 | Peter Sutovsky Gerald Sehatten | 1997 | Biologv of reproduction1997，56，： | 1 |
| 11 | Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes显示文摘 | Sutovsky P Manandhar G Laurincik J | 2005 | Reproduction2005，129，3： | 1 |
| 12 | The sperm proteasome during sperm capacitation and fertilization显示文摘 | ZIMMERMAN S SUTOVSKY P | 2009 | J Reprod Immunol2009，83，12： | 1 |
| 13 | Mitochondrial distribution and microtubule organization in fertilized and cloned porcine embryos: Implications for developmental potential显示文摘 | Mika Katayama Zhisheng Zhong Liangxue Lai Peter Sutovsky Randall S. Prather Heide Schatten | 2006 | Developmental Biology2006，，1： | 1 |
| 14 | Proteaso- mal interference prevents zona pellucida penetration and fertilization in mammals 显示文摘 | SUTOVSKY P MANANDHAR G McCAULEY T C | 2004 | Biol Repred2004，71，5： | 1 |
| 15 | Development of novel binary and ternary conductive composites based on polyethylene,low-melting-point metal alloy and carbon black显示文摘 | BORMASHENKO E SUTOVSKI S POGREB R | 2004 | Journal of Thermoplastic Composite Materials2004，17，3： | 1 |
| 16 | Development of pronuclei in pig oocytes activated by a single electric pulse显示文摘 | Prochazka R Kanka J Sutovsky P | 1992 | J Reprod Fertil1992，96，： | 1 |
| 17 | SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9(H3K9)in the zygotic pronuclei improves porcine embryo development显示文摘Background: The histone code is an established epigenetic regulator of early embryonic development in mammals.The lysine residue K9 of histone H3(H3 K9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substrates. At present, little is known about SIRT1-modulation of H3 K9 in zygotic pronuclei and its association with the success of preimplantation embryo development. Therefore, we evaluated the effect of SIRT1 activity on H3 K9 methylation and acetylation in porcine zygotes and the significance of H3 K9 modifications for early embryonic development.Results: Our results show that SIRT1 activators resveratrol and BML-278 increased H3 K9 methylation and suppressed H3 K9 acetylation in both the paternal and maternal pronucleus. Inversely, SIRT1 inhibitors nicotinamide and sirtinol suppressed methylation and increased acetylation of pronuclear H3 K9. Evaluation of early embryonic development confirmed positive effect of selective SIRT1 activation on blastocyst formation rate(5.2 ± 2.9% versus 32.9 ± 8.1% in vehicle control and BML-278 group, respectively; P ≤ 0.05). Stimulation of SIRT1 activity coincided with fluorometric signal intensity of ooplasmic ubiquitin ligase MDM2, a known substrate of SIRT1 and known limiting factor of epigenome remodeling.Conclusions: We conclude that SIRT1 modulates zygotic histone code, obviously through direct deacetylation and via non-histone targets resulting in increased H3 K9 me3. These changes in zygotes lead to more successful pre-implantation embryonic development and, indeed, the specific SIRT1 activation due to BML-278 is beneficial for in vitro embryo production and blastocyst achievement. | Katerina Adamkova Young-Joo Yi Jaroslav Petr Tereza Zalmanova Kristyna Hoskova Pavla Jelinkova Jiri Moravec Milena Kralickova Miriam Sutovsky Peter Sutovsky Jan Nevoral | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 1 |
| 18 | Uiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos 显示文摘 | Sutovsky P Moreno R Ramalho-Santos J | 2000 | Biol Reprod2000，63，： | 1 |
| 19 | Adult onset cerebral form of X-linked adrenoleukodystrophy with dementia of frontal lobe type with new L160P mutation in ABC D 1 gene 显示文摘 | SUTOVSKY S PETROVIC R CHANDOGA J | 2007 | J Neurol Sci2007，263，12： | 1 |
| 20 | Assembly of nuclear pore complexes and annulate promotes normal pronu clear development in fertilized mammalian oocytes 显示文摘 | Sutovsky P Simerly C Hewiston L | 1998 | J Cell Sci1998，111，19： | 1 |
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