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您的检索式：作者名="Sutticha Ruangchuay"
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| 1 | Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans显示文摘Objective: This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis elegans.Methods: THP-R-SR012 decoction was selected from 23 polyherbal medicines, based on metal-chelating and chain-breaking antioxidant capacities. The influences of this extract on the survival and some stress biomarkers of C. elegans under paraquat-induced oxidative stress were evaluated. Furthermore, lifespan analysis and levels of lipofuscin accumulation were examined in senescent nematodes. The phytochemical profile of THP-R-SR012 was analyzed.Results: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Further, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood.Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were rutin, naringenin, 3,4-dihydroxybenzoic acid, gallic acid, glycyrrhizic acid, demethoxycurcumin and 18 a-glycyrrhetinic acid.Conclusion: The antioxidant potential of THP-R-SR012 was due to its scavenging properties, its enhancement of antioxidant-related enzyme activities, and the presence of the antioxidant-related compound.These results support the traditional use of THP-R-SR012 decoction as a tonic for nourishing and strengthening the whole body. | Sutticha Ruangchuay Qiang-qiang Wang Liang-yi Wang Jing Lin Yong-chao Wang Guo-huan Zhong Katesarin Maneenoon Ze-bo Huang Sasitorn Chusri | 2021 | Journal of Integrative Medicine2021，19，4： | 1 |
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