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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Contributions of climate change and human activities to ET and GPP trends over North China Plain from 2000 to 2014显示文摘确定土壤水分蒸发蒸腾损失总量(et ) 和粗野主要生产率(GPP ) 改变的生态系统的气候变化和人的活动的贡献为改编评价和持续开发是重要的。et 和 GPP 的空间与时间的模式与一个物理、遥远的基于感觉的模型一起在诺思中国平原(NCP ) 上从 2000 ~ 2014 被估计。et 和 GPP 趋势的气候变化和人的活动的贡献被第一个差别趋势 de 方法和 multivariate 回归分开并且确定。结果显示出那年度 et , GPP 微弱地增加了,与气候变化和人的活动贡献 0.188 公里 yr-2 和 0.466 公里年-2到 0.654 公里年-2,的 et 趋势 and-1.321 g C m -2年-2和 7.542 g C m -2年-2到 GPP 6.221 的趋势 g C m -2年-2,分别地。在农田,增加的趋势主要在种舞台的小麦发生了;小麦和玉米的气候变化的贡献两个都是否定的。降水和阳光持续时间是调整 et 和 GPP 趋势的主要气候的因素。人的活动在 NCP 是到水消费和粗野主要生产率的长期的趋势的主要司机,这被结束。 | CHEN Xuejuan MO Xingguo HU Shi LIU Suxia | 2017 | Journal of Geographical Sciences2017，27，6： | 11 |
| 3 | Effects of annealing treatment on the microstructure and electrochemical properties of low-Co hydrogen storage alloys containing Cu and Fe显示文摘The effects of annealing treatment on the microstructure and electrochemical properties of low-Co LaNi 3.55 Mn 0.35 Co 0.20 Al 0.20 Cu 0.75 Fe 0.10 hydrogen storage alloys were investigated. X-ray diffraction (XRD) analysis indicated that annealing treatment remarkably reduced the lattice strain and defects, and increased the unit-cell volume. The optical microscope analysis showed that the as-cast alloy had a crass dendrite microstructure with noticeable composition segregation, which gradually disappeared with increasing annealing temperature, and the micro-structure changed to an equiaxed structure after annealing the alloy at 1233 K. The electrochemical tests indicated that the annealed alloys demonstrated much better cycling stability compared with the as-cast one. The capacity retention at the 100th cycle increased from 90.0% (as-cast) to 94.7% (1273 K). The annealing treatment also improved the discharge capacity. However, the high rate dischargeability (HRD) value of the annealed alloy slightly dropped, which was believed to be ascribed to the decreased exchange current density and the hydrogen diffusion coefficient in alloy bulk. | YANG Suxia LIU Zhiping HAN Shumin ZHANG Wei SONG Jianzheng | 2011 | Rare Metals2011，30，5： | 10 |
| 4 | An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T(CAR-T) cells显示文摘Anti-CD19 chimeric antigen receptor-modified T(CAR-T-19) cells have emerged as a powerful targeted immunotherapy for B-cell lineage acute lymphoblastic leukemia with a remarkable clinical response in recent trials. Nonetheless, few data are available on the subsequent clinical monitoring and treatment of the patients, especially those with disease recurrence after CAR-T-19 cell infusion. Here, we analyzed three patients who survived after our phase I clinical trial and who were studied by means of biomarkers reflecting persistence of CAR-T-19 cells in vivo and predictive factors directing further treatment. One patient achieved 9-week sustained complete remission and subsequently received an allogeneic hematopoietic stem cell transplant. Another patient who showed relapse after 20 weeks without detectable leukemia in the cerebrospinal fluid after CAR-T-19 cell treatment was able to achieve a morphological remission under the influence of stand-alone low-dose chemotherapeutic agents. The third patient gradually developed extensive extramedullary involvement in tissues with scarce immune-cell infiltration during a long period of hematopoietic remission after CAR-T-19 cell therapy. Long-term and discontinuous increases in serum cytokines(mainly interleukin 6 and C-reactive protein) were identified in two patients(Nos. 1 and 6) even though only a low copy number of CAR molecules could be detected in their peripheral blood. This finding was suggestive of persistent functional activity of CAR-T-19 cells. Combined analyses of laboratory biomarkers with their clinical manifestations before and after salvage treatment showed that the persistent immunosurveillance mediated by CAR-T-19 cells would inevitably potentiate the leukemia-killing effectiveness of subsequent chemotherapy in patients who showed relapse after CAR-T-19-induced remission. | Yajing Zhang Wenying Zhang Hanren Dai Yao Wang Fengxia Shi Chunmeng Wang Yelei Guo Yang Liu Meixia Chen Kaichao Feng Yan Zhang Chuanjie Liu Qingming Yang Suxia Li Weidong Han | 2016 | Science China(Life Sciences)2016，59，4： | 6 |
| 5 | Assessing the impact of climate change on potential evapotranspiration in Aksu River Basin显示文摘土壤水分蒸发蒸腾损失总量是水文学过程的关键部件之一。在土壤水分蒸发蒸腾损失总量上估计气候因素的影响在在水文学过程上理解气候变化的影响是有用的。在这份报纸,基于从 1960 ~ 2007 的每天气象学的数据在以内并且在 Aksu 河盆附近,引用土壤水分蒸发蒸腾损失总量(沤) 与 FAO Penman-Monteith 方法被估计。时间、空间的变化沤被使用 ARCGIS 和 Mann-Kendall 方法分析。多重回归分析被采用归因空气温度,太阳的放射,相对湿度,蒸汽压力和风速度的变化的效果在上沤。结果显示出那一般水准年度在 Aksu 河盆的东方平凡区域沤在西方的多山的区域像那一样将近是大约 1100 公里,它是两次。趋势年度沤有的重要空间可变性。年度沤在东南的绿洲区域和西南的平凡区域显著地被减少并且在山区稍微增加了。变化的振幅沤到达在夏天最高,年度变化的作出贡献的大多数沤。除了在相对湿度支配了 RET 的变化的一些高举起区域,风速度的变化支配了变化几乎在整个盆沤。作为一个例子拿 Kuqa 和 Ulugqat 车站,风速度的变化占了超过 50% 变化沤。 | ZHANG Shouhong LIU Suxia MO Xingguo SHU Chang SUN Yang ZHANG Chun | 2011 | Journal of Geographical Sciences2011，21，4： | 5 |
| 6 | Estimating the minimum in-stream flow requirements via wetted perimeter method based on curvature and slope techniques显示文摘Under the assumptions of triangular cross section channel and uniform stable flow, an analytical solution of the minimum ecological in-stream flow requirement (MEIFR) is deduced. Based on the analytical solution, the uncertainty of the wetted perimeter method is analyzed by comparing the two techniques for the determination of the critical point on the relationship curve between wetted perimeter, P and discharge, Q. It is clearly shown that the results of MEIFR based on curvature technique (corresponding to the maximum curvature) and slope technique (slope being 1) are significantly different. On the P-Q curve, the slope of the critical point with the maximum curvature is 0.39 and the MEIFR varied prominently with the change of the slope threshold. This indicates that if a certain value of the slope threshold is not available for slope technique, curvature technique may be a better choice. By applying the analytical solution of MEIFR in the losing rivers of the Western Route South-to-North Water Transfer Project in China, the MEIFR value via curvature technique is 2.5%-23.7% of the multi-year average annual discharge, while that for slope technique is 11%-105.7%. General conclusions would rely on the more detailed research for all kinds of cross-sections. | LIU Suxia' MO Xingguo XIA Jun LIU Changming LINZhonghui MEN Baohui JI Lina | 2006 | Journal of Geographical Sciences2006，16，2： | 2 |
| 7 | Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is characterized by the highest mortality among carcinomas.The pathogenesis of PDAC requires elevated autophagy,inhibition of which using hydroxychloroquine has shown promise.However,current realization is impeded by its suboptimal use and unpredictable toxicity.Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid and accessible approach.Here,using a patient-derived organoid model,we performed a comparative analysis of therapeutic responses among various antimalarial/fungal/parasitic/viral agents,through which econazole(ECON),an antifungal compound,emerged as the top candidate.Further testing in cell-line and xenograft models of PDAC validated this activity,which occurred as a direct consequence of dysfunctional autophagy.More specifically,ECON boosted autophagy initiation but blocked lysosome biogenesis.RNA sequencing analysis revealed that this autophagic induction was largely attributed to the altered expression of activation transcription factor 3(ATF3).Increased nuclear import of ATF3 and its transcriptional repression of inhibitor of differentiation-1(ID-1)led to inactivation of the AKT/mammalian target of rapamycin(m TOR)pathway,thus giving rise to autophagosome accumulation in PDAC cells.The magnitude of the increase in autophagosomes was sufficient to elicit ER stress-mediated apoptosis.Furthermore,ECON,as an autophagy inhibitor,exhibited synergistic effects with trametinib on PDAC.This study provides direct preclinical and experimental evidence for the therapeutic efficacy of ECON in PDAC treatment and reveals a mechanism whereby ECON inhibits PDAC growth. | Ningna Weng Siyuan Qin Jiayang Liu Xing Huang Jingwen Jiang Li Zhou Zhe Zhang Na Xie Kui Wang Ping Jin Maochao Luo Liyuan Peng Edouard C.Nice Ajay Goel Suxia Han Canhua Huang Qing Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 8 | Secondary structural analysis of the mRNA regions encoding the hemagglutinin cleavage site basic amino acids of the avian influenza virus H5N1 subtype samples显示文摘Here we report the codon bias and the mRNA secondary structural features of the hemagglutinin(HA)cleavage site basic amino acid regions of avian influenza virus H5N1 subtypes.We have developed a dynamic extended folding strategy to predict RNA secondary structure with RNAstructure 4.1 program in an iterative extension process.Statistical analysis of the sequences showed that the HA cleavage site basic amino acids favor the adenine-rich codons,and the corresponding mRNA fragments are mainly in the folding states of single-stranded loops.Our sequential and structural analyses showed that to prevent and control these highly pathogenic viruses,that is,to inhibit the gene expression of avian influenza virus H5N1 subtypes,we should consider the single-stranded loop regions of the HA cleavage site-coding sequences as the targets of RNA interference. | ZHANG SuXia WANG Xin CHEN XueFeng CAO Huai ZHANG Wen LIU CiQuan | 2008 | Chinese Science Bulletin2008，53，3： | 2 |
| 9 | Strong optical transmission through the ellipsoid metal-film nanohole arrays显示文摘The transmission characteristics of a metallic film with subwavelength ellipsoid nanohole arrays are investigated by using the three-dimensional finite-difference time-domain (3D-FDTD) method. The extraordinary transmission is attributed to the collaboration of localized waveguide resonance and surface plasmon resonance. The influences of the lattice constant and the hole shape on the transmission are studied. By analyzing the picture of electric field and electromagnetic energy distribution, we show the mechanisms of the two different resonances: Localized waveguide resonance mode can be confined inside the ellipsoid holes region, while electric field and electromagnetic energy are localized separately at the two ends of ellipsoid holes for the surface plasma resonance mode. | LI HongJian XIE SuXia ZHOU Xin LIU Qiong XIA Hui | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 2 |
| 10 | Experimental and Molecular Simulation of Volumetric Properties of Methyl Nonanoate,n-Dodecane,and Their Binary Mixtures显示文摘Densities of methyl nonanoate,n-dodecane,and their binary mixtures were investigated to provide the necessary data for their engineering applications as promising fuels and fuel additives.In the present work,densities were measured under atmospheric pressure at 293.15—463.15 K.The density data for the binary mixtures were fitted into a forai of excess molar volume.The excess molar volumes were mostly positive,and the maximum value was obtained at molar fractions of n-dodecane between 0.5 and 0.6.Molecular simulations of specified systems were carried out by using four kinds of force fields,and the suitable force fields for describing the volume properties of the system were AMBER96 and OPLS-AA.The relative deviations for these two force fields between the simulated and the experimental data were well within±4%,which meets the general engineering requirement. | ZANG Dongyun ZHAO Guanjia LIU Xiaona YIN Jianguo MA Suxia | 2019 | Chemical Research in Chinese Universities2019，35，2： | 1 |
| 11 | Ultra- sound tunneling through 3D phononic crystals显示文摘 | Yang Suxia Page1 J H Liu Zhengyou | 2002 | Phys- ical Review Letters2002，88，10： | 1 |
| 12 | Analysis of the impact of the MRT system on accessibility in Singapore using an integrated GIS tool显示文摘 | Zhu Xuan Liu Suxia | 2004 | Journal of Transport Geography2004，12，2： | 1 |
| 13 | Analysis of the impact of the MRT sys- tem on accessibility in Singapore using an integrated GIS tool 显示文摘 | Zhu Xuan Liu Suxia | 2004 | Journal of Transport Geography2004，12，： | 1 |
| 14 | Simulating tem- poral and spatial variation of evapotranspiration over the Lushi basin显示文摘 | Mo Xingguo Liu Suxia Lin Zhonghui | 2004 | J Hydrology2004，285，14： | 1 |
| 15 | Ultrasound tunneling through 3D phononic crystals显示文摘 | YANG Suxia PAGE J H LIU Zhengyou | 2002 | Physical Review Letters2002，88，10： | 1 |
| 16 | Regional crop yield,water consumption and water use efficiency and their responses to climate change in the North China Plain显示文摘 | Mo Xingguo Liu Suxia Lin Zhonghui | 2009 | Agriculture Ecosystems and Environment2009，134，： | 1 |
| 17 | USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation显示文摘Inflammasomes are essential components of the innate immune system and its defense against infections,whereas the dysregulation of inflammasome activation has a detrimental effect on human health.The activation of inflammasomes is subjected to tight regulation to maintain immune homeostasis,yet the underlying mechanism remains elusive.Here,we identify USP3 as a direct deubiquitinating enzyme(DUB)for ASC,the central adapter mediating the assembly and activation of most inflammasomes.USP3 removes the K48-linked ubiquitination on ASC and strengthens its stability by blocking proteasomal degradation.Additionally,USP3 promotes inflammasome activation,and this function was confirmed in mouse models of aluminum(Alum)-induced peritonitis,F.novicida infection and flagellin-induced pneumonia in vivo.Our work unveils that USP3 functions as a key regulator of ASC ubiquitination and maintains the physiological role of ASC in mediating inflammasome activation,and we propose a new mechanism by which the ubiquitination of ASC regulates inflammasome activation. | Wanxin Zhuang Lei Zhang Yi Zheng Bingyu Liu Chunhong Ma Wei Zhao Suxia Liu Feng Liu Chengjiang Gao | 2022 | Cellular & Molecular Immunology2022，19，10： | 1 |
| 18 | Simulating Temporal and Spatial Variation of Evapotranspiration over the Lushi Basin 显示文摘 | Mo Xingguo Liu Suxia Lin Zhonghui | 2004 | Journal of Hydrology2004，285，： | 1 |
| 19 | Regional crop yield, water consumption and water use efficiency and their responses to climate change in the North China Plain显示文摘 | Mo Xingguo Liu Suxia Lin Zhonghui | 2009 | Agriculture Ecosystems & Environment2009，134，12： | 1 |
| 20 | Simulating temporal and spatial variation of evapotranspiration over the Lushi basin显示文摘 | Xingguo Mo Suxia Liu Zhonghui Lin Weimin Zhao | 2003 | Journal of Hydrology2003，，1： | 1 |
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