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| 1 | Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy显示文摘AIM: To assess the safety of enhanced recovery after surgery(ERAS) program in gastrectomy and influences on nutrition state and insulin-resistance. METHODS: Our ERAS program involved shortening the fasting periods and preoperative carbohydrate loading. Eighty gastrectomy patients were randomly assigned to either the conventional group(CG) or ERAS group(EG). We assessed the clinical characteristics and postoperative outcomes prospectively. The primary endpoint was noninferiority in timely discharge from the hospital within 12 d. Secondary endpoints were the incidence of aspiration at anesthesia induction, incidence of postoperative complications, health related quality of life(HRQOL) using the SF8 Health Survey questionnaire, nutrition state [e.g., albumin, transthyretin(TTR), retinal-binding protein(RBP), and transferrin(Tf)], the homeostasis model assessment-insulin resistance(HOMA-R) index, postoperative urine volume,postoperative weight change, and postoperative oral intake.RESULTS: The ERAS program was noninferior to the conventional program in achieving discharge from the hospital within 12 d(95.0% vs 92.5% respectively; 95%CI:-10.0%-16.0%). There was no significant difference in postoperative morbidity between the two groups. Adverse events such as vomiting and aspiration associated with the induction of general anesthesia were not observed. There were no significant differences with respect to postoperative urine volume, weight change, and oral intake between the two groups. EG patients with preoperative HOMA-R scores above 2.5 experienced significant attenuation of their HOMA-R scores on postoperative day 1 compared to CG patients(P = 0.014). There were no significant differences with respect to rapid turnover proteins(TTR, RBP and Tf) or HRQOL scores using the SF8 method.CONCLUSION: Applying the ERAS program to patients who undergo gastrectomy is safe, and improves insulin resistance with no deterioration in QOL. | Nobuaki Fujikuni Kazuaki Tanabe Noriaki Tokumoto Takahisa Suzuki Minoru Hattori Toshihiro Misumi Hideki Ohdan | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 23 |
| 2 | Treatment of gastric remnant cancer post distal gastrectomy by endoscopic submucosal dissection using an insulation-tipped diathermic knife显示文摘AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with gastric remnant cancer. METHODS: Thirty-two patients with early gastric cancer in the remnant stomach, who underwent distal gastrectomy due to gastric carcinoma, were treated with endoscopic mucosal resection (EMR) or ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 10-year period from January 1998 to December 2007, including 17 patients treated with IT-ESD. Retrospectively, patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, and perforation rate were compared between patients treated with conventional EMR and those treated with IT-ESD. RESULTS: The CR rate (40% in the EMR group vs 82% in the IT-ESD group) was significantly higher in the IT-ESD group than in the EMR group; however, the operation time was significantly longer for the IT- ESD group (57.6 ± 31.9 min vs 21.1 ± 12.2 min). No significant differences were found in the rate of underlying cardiopulmonary disease (IT-ESD group, 12% vs EMR group, 13%), one-piece resection rate (100% vs 73%), bleeding rate (18% vs 6.7%), and perforation rate (0% vs 0%) between the two groups. CONCLUSION: IT-ESD appears to be an effective treatment for gastric remnant cancer post distal gastrectomy because of its high CR rate. It is useful for histological confirmation of successful treatment. Thelong-term outcome needs to be evaluated in the future. | Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujitav Shuji Matsumura Seiyuu Suzuki | 2008 | World Journal of Gastroenterology2008，14，16： | 18 |
| 3 | Treatment of over 20 mm gastric cancer by endoscopic submucosal dissection using an insulation-tipped diathermic knife显示文摘AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with over 20 mm early gastric cancer (EGC). METHODS: A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group (21-40 mm)] and the remaining patients (under 20 mm group). RESULTS: We found no significant difference in the rate of underlying cardiopulmonary disease (over 20 mm group vs under 20 mm group, 5.0% vs 5.6%), one- piece resection rate (95% vs 96%), CR rate (85% vs 89%), operation time (72.3 min vs 66.5 min), bleeding rate (5% vs 4.2%), and perforation rate (0% vs 1.4%) between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION: There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future. | Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujita Fusao Ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki | 2007 | World Journal of Gastroenterology2007，13，29： | 13 |
| 4 | Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget’s disease with curative responses显示文摘Background:Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease(EMPD)of the genital region is wide surgical excision of the lesion,the procedure is highly invasive and can lead to functional and sexual problems.Alternative treatments have been used for local control when wide local exci-sion was not feasible.Here,we describe four patients with genital malignancies who were treated with boron neutron capture therapy(BNCT).Methods:The four patients included one patient with vulvar melanoma(VM)and three with genital EMPD.They underwent BNCT at the Kyoto University Research Reactor between 2005 and 2014 using para-boronophenylalanine as the boron delivery agent.They were irradiated with an epithermal neutron beam between the curative tumor dose and the tolerable skin/mucosal doses.Results:All patients showed similar tumor and normal tissue responses following BNCT and achieved complete responses within 6 months.The most severe normal tissue response was moderate skin erosion during the first 2 months,which diminished gradually thereafter.Dysuria or contact pain persisted for 2 months and resolved com-pletely by 4 months.Conclusions:Treating VM and EMPD with BNCT resulted in complete local tumor control.Based on our clinical expe-rience,we conclude that BNCT is a promising treatment for primary VM and EMPD of the genital region. | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | Cancer Communications2018，38，1： | 10 |
| 5 | Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer显示文摘 | Minoru Oshima Keiichi Okano Shinobu Muraki Reiji Haba Takashi Maeba Yasuyuki Suzuki Shinichi Yachida | 2013 | Annals of Surgery2013，，2： | 4 |
| 6 | Three cases of Solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum显示文摘A solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum is rare, and few reports have described its characteristic endoscopic features. We describe three cases of solitary Peutz-Jeghers-type hamartomatous polyp and their endoscopic findings in detail. The polyp in all of our three cases showed an irregularly lobular or nodular surface, whereas adenomas often show a regularly nodular or granular surface. The color of the polyp was whitish in all of our cases. In the present cases, close observation by endoscopy revealed that the solitary Peutz-Jeghers-type hamartomatous polyps looked whitish because of the presence of diffusely scattered white spots on the surface of the polyps. Duodenal polyps that exhibit the aforementioned endoscopic characteristics may be diagnosed as Peutz-Jeghers-type hamartomatous polyps and treated by polypectomy because of the malignant potential. | Seiyuu Suzuki Shoji Hirasaki Fusao Ikeda Eiichiro Yumoto Hiromichi Yamane Minoru Matsubara | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 7 | 运用免疫荧光法检测温热对于硼化合物细胞微分布影响显示文摘目的硼中子俘获疗法(BNCT)的有效性主要取决于硼-10元素在肿瘤细胞内的聚集。目前的硼检测手段仅限于分析肿瘤组织中硼的平均浓度,不能准确地评价硼化合物(BPA)在组织中的详细分布。先前研究证实温热处理可以提高放疗疗效,本研究通过免疫荧光法检测温热是否对BPA细胞内的微分布有影响。方法通过免疫荧光法分析硼化合物在肿瘤细胞中的分布以及温热对BPA分布的影响。在体外对人肺癌细胞株A549和人头颈部鳞状细胞癌细胞株SAS进行培养,并且加入BPA共培养1h。另外,A549细胞经温热处理1h后,利用抗BPA抗体通过免疫荧光法进行检测。免疫荧光强度通过图像分析软件进行分析。结果检测发现BPA主要聚集于细胞核周围,BPA免疫荧光的强度随着培养基中BPA浓度的增加而增强。尽管在26μg/ml浓度和13μg/ml浓度时,细胞免疫荧光的平均强度相近,但直方图分析发现26μg/ml时细胞主要向高荧光强度区域移动。经温热处理后,BPA在细胞中的分布没有明显增加。结论本研究利用免疫荧光法对BPA在细胞内的分布进行了分析,以上结果暗示温热对肿瘤细胞硼摄取的影响可能主要需要通过改善肿瘤循环、增加肿瘤内BPA的输送来实现。 | 刘勇 Kashino Genro 陈一瑋 Masunaga Shin-ichiro Suzuki Minoru Kinashi Yuko Kirihata Mitsunori Ono Koji | 2012 | 中华临床医师杂志(电子版)2012，6，10： | 3 |
| 8 | 硼中子俘获治疗外阴黑色素瘤和生殖器乳腺外Paget病的疗效显示文摘背景与目的尽管目前对生殖器区的黑色素瘤和乳腺外Paget病(extramammary Paget’s disease,EMPD)最常推荐的治疗方法是广泛性手术切除病变,但该方法侵害性极高并可导致功能性和性方面的问题。当扩大局部切除术不可行的情况下,替代疗法已被用于进行局部控制。本研究描述了4例接受硼中子俘获治疗(boron neutron capture therapy,BNCT)的生殖器恶性肿瘤患者。方法 4例患者中包括1例外阴黑色素瘤(vulvar melanoma,VM)和3例生殖器EMPD患者。他们于2005至2014年间在Kyoto大学研究堆接受了对二羟基硼酰苯丙氨酸作为硼携带剂的BNCT治疗。他们接受了介于治愈性肿瘤剂量和可耐受的皮肤/黏膜剂量之间的超热中子束照射。结果所有患者在BNCT治疗后均表现出相似的肿瘤和正常组织反应,并在6个月内达到完全缓解。最严重的正常组织反应前2个月内出现,随后逐渐减弱的中度皮肤糜烂,排尿困难或接触性疼痛持续2个月,完全解决需4个月。结论 BNCT治疗VM和EMPD后局部肿瘤得到完全控制。根据我们的临床经验,我们认为BNCT是治疗生殖器区原发性VM和EMPD的一种有前景的方法。 | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | 癌症2018，37，7： | 3 |
| 9 | A ruptured large extraluminal ileal gastrointestinal stromal tumor causing hemoperitoneum显示文摘We describe an 87-year-old woman with a large ileal gastrointestinal stromal tumor (GIST) causing hemoperitoneum. A CT scan demonstrated a large heterogeneous mass measuring about 13 cm × 11 cm in the pelvis and hemoperitoneum, with a non-uniform enhancement pattern. The mass was diagnosed as a GIST originating from the gastrointestinal tract. She underwent an urgent laparotomy and an ileal GIST with a rupture was found 130 cm from the anal to the Treitz’s ligament. Hemoperitoneum caused by ileal GIST rupture is a rare condition. Bleeding in the large tumor leading to rupture of the capsule might cause hemoperitoneum in the present case. | Shoji Hirasaki Kohei Fujita Minoru Matsubara Hiromitsu Kanzaki Hiromichi Yamane Masato Okuda Seiyuu Suzuki Atsuko Shirakawa Hideyuki Saeki | 2008 | World Journal of Gastroenterology2008，14，18： | 3 |
| 10 | Lack of Cholecystokinin-A Receptor Enhanced Gallstone Formation: A Study in CCK-A Receptor Gene Knockout Mice显示文摘 | Norikazu Sato Kyoko Miyasaka Shinji Suzuki Setsuko Kanai Minoru Ohta Takako Kawanami Yuki Yoshida Soichi Takiguchi Tetsuo Noda Yutaka Takata Akihiro Funakoshi | 2003 | Digestive Diseases and Sciences2003，，10： | 2 |
| 11 | In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage显示文摘 | Haruo Mitani Nobukazu Ishizaka Toru Aizawa Minoru Ohno Shin-ichi Usui Toru Suzuki Toshihiro Amaki Ichiro Mori Yasushi Nakamura Misako Sato Masaomi Nangaku Yasunobu Hirata Ryozo Nagai | 2002 | Hypertension: Journal of the American Heart Association2002，，4： | 1 |
| 12 | Aerodynamic characteristics of train/vehicles under cross winds显示文摘 | Minoru Suzuki Katsuji Tanemoto Tatsuo Maeda | 2002 | Journal of Wind Engineering & Industrial Aerodynamics2002，，： | 1 |
| 13 | Inflammatory pseudotumor of the liver: Case report and review of the literature显示文摘 | Masato Sakai Hitoshi Ikeda Norio Suzuki Atsushi Takahashi Minoru Kuroiwa Junko Hirato Shin-itsu Hatakeyama Yoshiaki Tsuchida | 2001 | Journal of Pediatric Surgery2001，，4： | 1 |
| 14 | Inflammatory fibroid polyp occurring in the transverse colon diagnosed by endoscopic biopsy显示文摘A case of an inflammatory fibroid polyp occurring in the transverse colon and diagnosed by endoscopic biopsy is reported. The patient was an 82-year-old man who visited our hospital for further evaluation of occult blood in stool. The Colonoscopy revealed a small, red, and peduncular polyp, about 6 mm in diameter, in the transverse colon. Histological examination of the biopsy specimen obtained from the polyp revealed proliferation of fibroblasts and infiltration of inflammatory cells such as plasma cells and eosinophils. This polyp was diagnosed as an inflammatory fibroid polyp, which can appear in many different locations throughout gastrointestinal tract, though still rare in the transverse colon. | Shoji Hirasaki Minoru Matsubara Fusao Ikeda Hideaki Taniguchi Seiyuu Suzuki | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 15 | Biodistribution of 10B in a rat liver tumor model following intra-artefial administration of sodium borocaptate (BSH) /degradable starch mierosphere (DSM) emulsion 显示文摘 | Minoru Suzuki Kenji Nagata Shinichiro Masunaga et ol | 2004 | Applied Radiation and Isotopes2004，61，： | 1 |
| 16 | Biodistribution of 10B in a rat liver tumor model following intra-arterial administration of sodium borocaptate (BSH)/degradable starch microsphere (DSM) emulsion显示文摘 | Minoru Suzuki Kenji Nagata Shinichiro Masunaga | 2004 | Applied Radiation and Isotopes2004，61，： | 1 |
| 17 | The combined effect of boronophenylalanine and borocaptate in boron neutron capture therapy for SCCVⅡ tumors in mice 显示文摘 | Ono Koji Masunaga Shinichiro Suzuki Minoru | 1999 | International Journal of Radiation Oncology Biology Physics1999，43，2： | 1 |
| 18 | EDM of micro-rods by self-drilled holes显示文摘 | Minoru Yamazaki Takemi Suzuki Noritoshi Mori Masanori Kunieda | 2004 | Journal of Materials Processing Technology2004，149，13： | 1 |
| 19 | Biodistribution of 10B in a rat liver tumor model following intra -arterial administration of sodium boro- eaptate(BSH) /degradable starch microsphere ( DSM ) emulsion 显示文摘 | Minoru Suzuki Kenji Nagata Shinichiro Masunaga | 2004 | Applied Radiation and Isotopes2004，61，： | 1 |
| 20 | Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma 显示文摘 | Takashi Imai Minoru Toyota Hiromu Suzuki | 2008 | Cancer Sci2008，99，5： | 1 |
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