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| 1 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 2 | Sand dunes as potential sources of dust in northern China显示文摘While saltation bombardment of sand grains on a fine substrate can produce considerable dust, the well-sorted nature of sand dunes tends to preclude them from consideration as major dust sources. Recent research, however, has revealed that sand dunes can, in some cases, be large sources of dust. We used the PI-SWERL(Portable In-Situ Wind Erosion Laboratory) to measure in the field the potential of sand dunes and other desert landforms to emit particulate matter <10 μm(PM-10) dust in the Tengger, Ulan Buh, and Mu Us deserts of northern China. Combined with high resolution particle size measurements of the dune sand, an assessment of sand dunes as a dust source can be made. Large active transverse dunes tend to contain little to no stored PM-10, yet they produce a low dust flux. Coppice dunes stabilized by vegetation contain appreciable PM-10 and have very high dust emission potential. There is a positive correlation between the amount of PM-10 stored in a dune and its potential dust flux. Saltation liberates loose fines stored in dunes, making them very efficient dust emitters compared to landforms such as dry lake beds and washes where dust particles are unavailable for aeolian transport due to protective crusts or sediment cohesion. In cases where large dunes do not store PM-10 yet emit dust when active, two hypotheses can be considered:(1) iron-oxide grain coatings are removed during saltation, creating dust, and(2) sand grains collide during saltation, abrading grains to create dust. Observations reveal that iron oxide coatings are present on some dune sands. PI-SWERL data suggests that low dust fluxes from dunes containing no stored dust may represent an estimate for the amount of PM-10 dust produced by removal of iron oxide coatings. These results are similar to results from dunes in the United States. In addition, PI-SWERL results suggest that dust-bearing coppice dunes, which cover vast areas of China's sandy deserts, may become major sources of dust in the future if overgrazing, depletion of groundwater, or drought destabilizes the vegetation that now partially covers these dunes. | Mark R SWEENEY LU HuaYu CUI MengChun Joseph A MASON FENG Han XU ZhiWei | 2016 | Science China Earth Sciences2016，59，4： | 2 |
| 3 | Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin显示文摘 | PALANIVEL R SWEENEY G | 2005 | FEBS Lett2005，579，22： | 1 |
| 4 | Incidentally detected renal cell carcinoma: pathological features,survival trends and implications for treatment 显示文摘 | SWEENEY JP THORNHILL JA GRAINGER R | 1996 | Br J Urol1996，78，3： | 1 |
| 5 | The reversal of large stock-price decreases显示文摘 | Bremer M Sweeney R J | 1991 | The Journal of Finance1991，46，2： | 1 |
| 6 | Activation of the glucose transporter GLUT4 by insulin显示文摘 | Furtado LM Somwar R Sweeney G | 2002 | Biochem Cell Biol2002，80，5： | 1 |
| 7 | Subsidy free pricing of interruptible service contracts 显示文摘 | BEARD T R SWEENEY H GROPPER D M | 1995 | Energy Economics1995，17，1： | 1 |
| 8 | Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study显示文摘 | Louis GMB Sundaram R Sweeney AM | 2014 | Fertil Steril2014，101，： | 1 |
| 9 | Incidentally detected renal cell carcinoma: pathological features, survival trends and implications for treatment显示文摘 | SWEENEY JP THORNHILL JA GRAINGER R | 1996 | Br J Urol1996，78，3： | 1 |
| 10 | Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA显示文摘 | ROSS R J SWEENEY M G | 1992 | Lancet1992，340，： | 1 |
| 11 | Incidentally detected renal cell carcinom a: pathological features, survival trends and implications for treatment 显示文摘 | Sweeney JP Thornhill JA Graiger R | 1996 | Br J Urol1996，78，3： | 1 |
| 12 | Gear transmission error measurement using phase demodulation显示文摘 | Sweeney P J Randall R B | 1996 | Journal of Mechanical Engineering Science1996，210，3： | 1 |
| 13 | Detecting Earnings Management显示文摘 | Dechow P R Sloan A Sweeney | 1995 | The Accounting Review1995，，70： | 1 |
| 14 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 15 | Detecting earnings management 显示文摘 | Dechow P M Sloan R G Sweeney A P | 1995 | The Accounting Review1995，70，： | 1 |
| 16 | Random amplification polymorphic DNA analysis of dry turfgrass seed显示文摘 | Sweeney P M Golembiewski R Danneberger T K | 1996 | Hort Sci1996，31，3： | 1 |
| 17 | Repositioning accuracy: comparison of a noninvasive head holder with thermoplastic mask for fractionated radiotherapy and a case report 显示文摘 | Sweeney R Bale R Vogele M | 1998 | Int J Radiat Oncol Bid Phys1998，41，2： | 1 |
| 18 | Contribution of satellite cells to igf-1 induced hypertrophy of skeletal muscle 显示文摘 | Barton-Davis E R D I Shoturma H L Sweeney | 1999 | Acta Physiol Seand1999，167，： | 1 |
| 19 | An atmospheric perspective on North American carbon dioxide exchange: CarbonTracker 显示文摘 | Peters W Jacobson A R Sweeney C | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，18： | 1 |
| 20 | Activation of the glucose transporter GLUT4 by insulin显示文摘 | Furtado LM Somwar R Sweeney G | 2002 | Biochem Cell Biology2002，80，5： | 1 |
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