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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Evoluation of the infant spinal column:evoluation with MR imaging显示文摘 | Sze G Baierl P Bravo S | 1991 | Radiology1991，181，81： | 1 |
| 3 | Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm,Bombyx mori显示文摘 | DEDOS S G SZURDOKI F SZE A | 2002 | Pesticide Biochemistry and Physiology2002，73，： | 1 |
| 4 | Contributory factors to traffic crashes at signalized intersections in Hong Kong显示文摘 | Wong S C Sze N N Li Y C | 2007 | Accident Analysis & Prevention2007，39，6： | 1 |
| 5 | Treatment results for naso- pharyngeal carcinoma in the modern era: the Hong Kong experi- ence显示文摘 | LEE A W SZE W M AU J S | 2005 | Int J Radiat Oncol Biol Phys2005，61，4： | 1 |
| 6 | Developing spine column: gadolinium-enhanced MR imaging显示文摘 | Sze G Bravo S Haierl P | 1991 | Radiology1991，181，1： | 1 |
| 7 | Volvariella volvacea lectinactivates mouse T lymphocytes l)y a calcium dependent pathway显示文摘 | Sze S C W Ho J C K Liu W K | 2004 | J Cell Biochem2004，92，6： | 1 |
| 8 | Treatment of hepatic venous outflow obstruction after piggyback liver transplantation 显示文摘 | Wang SL Sze DY Busque S | 2005 | Radiology2005，236，1： | 1 |
| 9 | Modeling complex heterogeneous objects with non-manifold heterogeneous cells 显示文摘 | Kou X Y Tan S T Sze W S | 2006 | Computer-Aided Design2006，38，： | 1 |
| 10 | The incremental harmonic balance method for nonlinear vibration of axially moving beams显示文摘 | Sze K Y Chen S H Huang J L | 2005 | Journal of Sound and Vibration2005，281，： | 1 |
| 11 | Influence of transverse normal strain and temperature profile on thermo-elasticity of sandwiches显示文摘 | Wu Zhen S H Lo K Y Sze | 2013 | J Thermal Stresses2013，，36： | 1 |
| 12 | Diagnostic analysis of the logistic model for pedestrian injury severity in traffic crashes显示文摘 | Sze N N Wong S C | 2007 | Accident Analysis and Prevention2007，39，6： | 1 |
| 13 | Multidimensional Lindstedt-Poineare method for nonlinear vibration of axially moving beams显示文摘 | Chen S H Huang J L Sze K Y | 2007 | Journal of Sound and Vibration2007，306，12： | 1 |
| 14 | iTRAQ-hased quantitative secretome analysis of Phanerochaete chrysosporium 显示文摘 | Manavalan A Adav S S Sze S K | 2011 | J Proteomics2011，75，2： | 1 |
| 15 | The incremental harmonic balance method for nonlinear vibration of axially moving beams 显示文摘 | Sze K Y Chen S H Huang J L | 2005 | Journal of Sound and Vibration2005，281，35： | 1 |
| 16 | Anti- Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? 显示文摘 | Song J X Sze S C Ng T B | 2012 | J Ethnopharmacol2012，139，3： | 1 |
| 17 | Hybrid-stress six-node prismatic elements 显示文摘 | Sze K Y Liu X H Lo S H | 2004 | International Journal for Numerical Methods in Engineering2004，61，9： | 1 |
| 18 | Parting line formation by slicing a 3D CAD model显示文摘 | WONG T TAN S T SZE W S | 1998 | Engineering with Computers1998，，14： | 1 |
| 19 | Tritium recovery from liquid metals显示文摘 | Moriyama H Tanaka S Sze D K | 1995 | Fusion Engineering and Design1995，28，22： | 1 |
| 20 | Multidimensionallindstedt-poincar6 method for nonlinear vibration ofaxially moving beams 显示文摘 | Chen S H Huang J L Sze K Y | 2007 | Journal of Sound and Vi-bration2007，306，1： | 1 |
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